Results 81 to 90 of about 1,272 (143)

Supramolecular synthon hierarchy in sulfonamide cocrystals with syn-amides and N-oxides

IUCrJ, 2019
Sulfonamide drugs are well known antibacterial and antimicrobial molecules for pharmaceutical development. Building a library of suitable supramolecular synthons for the sulfonamide functional group and understanding their crystal structures with partner
Geetha Bolla, Ashwini Nangia
doaj   +1 more source

Three Energetic 2,2′,4,4′,6,6′-Hexanitrostilbene Cocrystals Regularly Constructed by H‑bonding, π‑Stacking, and van der Waals Interactions

, 2018
Three new energetic 2,2′,4,4′,6,6′-hexanitrostilbene (HNS) cocrystals, HNS/4,4′-bipyridine, HNS/trans-1,2-bis­(4-pyridyl)­ethylene, and HNS/1,2-bis­(4-pyridyl)­ethane have been synthesized.
Hongli Zhang (518920), Jinjiang Xu (839434), Huaiyu Jiang (4960714), Yuxiang Guan (4358176), Shichun Li (3981683), Yu Liu (6938), Shiliang Huang (303592), Hui Huang (4122), Zeshan Wang (4960717)   +8 more
core   +1 more source

Elucidating the Complex Phase Behavior of a Cocrystal System Containing Two APIs and One Coformer

, 2018
A method has been developed to determine the phase behavior of a cocrystal system that contains two APIs (active pharmaceutical ingredients) and one coformer.
Pui Shan Chow (1410667), Reginald B. H. Tan (1410871), Zai-Qun Yu (6041708), Maria Paulene Abundo (6041705)   +3 more
core   +1 more source

Tracking Cocrystallization of Active Pharmaceutical Ingredients with Benzoic Acid Coformer Using Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS)

, 2018
This study investigates the use of Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS) as a detection method for the formation of cocrystals.
Christopher Kent (454183), Seán McSweeney (5823467), Anas Alfarsi, Anas Alfarsi (5823461), Seán McSweeney, U. B. Rao Khandavilli, Melissa Hanna-Brown (5823464), Jacob Krüse (2107174), Christopher Kent, Simon Lawrence, Dara Fitzpatrick, Dara Fitzpatrick (2107171), Melissa Hanna-Brown, Jacob Krüse, Simon Lawrence (5823470), U. B. Rao Khandavilli (1605853)   +15 more
core   +1 more source

Differences in Coformer Interactions of the 2,4-Diaminopyrimidines Pyrimethamine and Trimethoprim

The identification and study of supramolecular synthons is a fundamental task in the design of pharmaceutical cocrystals. The malaria drug pyrimethamine (pyr) and the antibiotic trimethoprim (tmp) are both 2,4-diaminopyrimidine derivatives, providing the
Ciaran O’Malley (5214854), Andrea Erxleben (1519126), Lamis Alaa Eldin Refat (12379093), Patrick McArdle (1457956), John M. Simmie (1503457)   +4 more
core   +1 more source

Tyramine as a prolific coformer in crystal engineering : insights from classical crystal structure analysis and electron density studies

Prolific coformers are compounds that readily form multicomponent crystals with diverse partners, playing a crucial role in crystal engineering by enabling the creation of new solids with enhanced physicochemical properties.
Gryl, Marlena, Grabowski, Szymon
core   +1 more source

Preparation and Characterization of a Rifampicin Coamorphous Material with Tromethamine Coformer: An Experimental–Theoretical Study

Rifampicin (RIF) is an antibiotic used to treat tuberculosis and leprosy. Even though RIF is a market-available drug, it has a low aqueous solubility, hindering its bioavailability.
Luís H. S. Queiroz (17976860), Mateus R. Lage (2031595), Paulo R. S. Ribeiro (10834884), Ranna S. Barros (17976863), Francisco F. de Sousa (7937051), Mafalda C. Sarraguça (17976866)   +5 more
core   +1 more source

STUDI KINETIKA-TERMODINAMIKA KELARUTAN DAN DISOLUSI INTRINSIK KOKRISTAL ATORVASTATIN

, 2017
Fakultas Farmasi Universitas Jember Jl.Kalimantan 37 JemberAtorvastatin termasuk obat BCS kelas II yaitu mempunyai permeabilitasnya besar namun kelarutan kecil sehingga bioavailabilitas peroralnya sangat rendah (sekitar 12%). Kokristal merupakan metode
Wisudyaningsih, B, Wicaksono, Y
core  

Flavonoid-Based Cocrystals: A Comprehensive Study on Their Synthesis, Characterization, Physicochemical Properties and Applications. [PDF]

Molecules
Maciołek UI, Kosińska-Pezda M, Martínez-Senra T, Losada-Barreiro S, Bravo-Díaz C.   +4 more
europepmc   +1 more source

Paliperidone Acid-Based Cocrystal for Improving Biopharmaceutical Properties: In Vitro and In Vivo Evaluation. [PDF]

ACS Omega
Elmowafy M, Alruwaili NK, Alsaidan OA, Elkomy MH, Abdelgawad MA, Ibrahim MF, Zidan MF, Elbahwy IA, Barakat EH.   +8 more
europepmc   +1 more source