Results 61 to 70 of about 649 (170)

Mechanochemically Driven Synthesis of Anticancer Cocrystals: A Case Study of Lenalidomide

Chemistry–Methods, Volume 6, Issue 5, May 2026.
The combination of crystal engineering and mechanochemical approaches is a powerful strategy for the rational screen and development of new solid forms of active pharmaceutical ingredients (API). New supramolecular patterns formed between an API and a coformer allow the adjustment of physicochemical properties of drugs.
Ana C. S. Carvalho, M. Teresa Duarte, Clara S. B. Gomes, Mafalda Sarraguça, Alessia Bacchi, Michele Prencipe, Job Gieling, Natalia Shemchuk, Daniel M. Baier, Koen Robeyns, Hector Polyzois, Lidia Tajber, Christos M. Chatzigiannis, Evelina Colacino, Tom Leyssens, Vânia André   +15 more
wiley   +1 more source

Supramolecular Sandwiches: Halogen-Bonded Coformers Direct [2+2] Photoreactivity in Two-Component Cocrystals

Molecules, 2020
The halogen-bond (X-bond) donors 1,3- and 1,4-diiodotetrafluorobenzene (1,3-di-I-tFb and 1,4-di-I-tFb, respectively) form cocrystals with trans-1,2-bis(2-pyridyl)ethylene (2,2′-bpe) assembled by N···I X-bonds.
Jay Quentin, Dale C. Swenson, Leonard R. MacGillivray   +2 more
doaj   +1 more source

Solubilities of CL‐20 and MDNT in Organic Solvents for Technical Cocrystallization

Propellants, Explosives, Pyrotechnics, Volume 51, Issue 5, Page 761-768, May 2026.
ABSTRACT The 1:1 molar cocrystal of 2,4,6,8,10,12‐hexanitro‐2,4,6,8,10,12‐hexaazaisowurtzitane (CL‐20) and 1‐methyl‐3,5‐dinitro‐1,2,4‐triazole (MDNT) is reported to show a detonation velocity 100 m/s faster than β‐HMX. To establish a scalable synthesis method, the solubility of ε‐CL‐20 and MDNT was investigated.
Eduard Wegert, Peter Schultz, Thomas M. Klapötke   +2 more
wiley   +1 more source

Charge Transport in Ternary Charge‐Transfer Solid Solution Single Crystals

Advanced Functional Materials, Volume 36, Issue 26, 30 March 2026.
This study deconvolutes the roles of indirect (superexchange) and direct electronic coupling on charge transport in single crystals of an organic charge‐transfer molecular semiconductor (OSC). This model system elegantly demonstrates that structural defects introduced by chemical dopants play a significant role in the electronic performance ...
Jonathan C. Novak, Manikanta Makala, Edith L. MacKenzie, Veaceslav Coropceanu, Kimberly Agosto, Abigail A. Moravek, Oana D. Jurchescu, Ren A. Wiscons   +7 more
wiley   +1 more source

Cocrystals of Isoniazid with Polyphenols: Mechanochemical Synthesis and Molecular Structure

Crystals, 2020
Isoniazid is used as anti-tuberculosis drug which possesses functional groups capable of forming hydrogen bonds. A series of cocrystals of isoniazid (INH) with polyphenolic coformers such as catechol (CAT), orcinol (ORC), 2-methylresorcinol (MER ...
Juan Saulo González-González, Ana María Monserrat Martínez-Santiago, Francisco Javier Martínez-Martínez, María José Emparán-Legaspi, Armando Pineda-Contreras, Marcos Flores-Alamo, Héctor García-Ortega   +6 more
doaj   +1 more source

Beyond Cocrystals: Hierarchical Functional Assemblies via Noncovalent Synthesis

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Non‐covalent interactions (NCIs) drive the formation of organic cocrystals with diverse structures and tunable optoelectronic properties. This review explores the essential factors governing these properties, highlighting how the sequential nucleation of cocrystals leads to the self‐assembly of organic hierarchical structures (OHSs).
Ya‐Nan Zhu, Jin Feng, Ying‐Xin Ma, Hong‐Tao Lin, Li‐Wei Xie, Qi‐Liang Peng, Xue‐Dong Wang   +6 more
wiley   +1 more source

Multicomponent crystals: Solubility enhancement of simvastatin using arginine and glycine coformers [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Simvastatin can be modified by the formation of multicomponent crystals to increase its solubility. Aims: To compare the solubility of multicomponent simvastatin crystals to pure simvastatin. Methods: The in silico study of simvastatin and
Iyan Sopyan, Karyn Elizabeth, Sandra Megantara, Silmy Kaffah   +3 more
doaj   +1 more source

Double Salts and Racemate in Mefloquine–Ibuprofen and Mefloquine–Ketoprofen Systems. A Structural and Thermochemical Analysis

Chirality, Volume 38, Issue 3, March 2026.
(S)‐ibuprofen or ketoprofen were used to resolve mefloquine, forming double salts structurally similar to the racemic forms. ABSTRACT The formation of salts remains a highly sought‐after yet unpredictable strategy for resolving chiral drugs. Using a drug–drug approach, we have investigated the crystallization behavior of Mefloquine (Mf), a racemic ...
Juliana B. Martins, João V. Segatto, Juan C. Tenorio, Paulo S. Carvalho Jr   +3 more
wiley   +1 more source

Larvicidal Activity of Naringenin: Betaine Cocrystals Against Aedes Aegypti

Crystal Research and Technology, Volume 61, Issue 2, February 2026.
This study demonstrates that naringenin: betaine cocrystals significantly enhance larvicidal activity against Aedes aegypti compared to physical mixtures or pure compounds. Improved dissolution properties contributed to higher mortality rates, supporting the use of cocrystallization as a promising green technology for vector management.
Felipe Zaniol, Patricia Viera de Oliveira, Daniel Albeny‐Simões, Jacir Dal Magro, José Vladimir de Oliveira   +4 more
wiley   +1 more source

Bio-Purines as Co-Formers in Resveratrol Amorphous Systems

Crystals
In the organic biomineralization of guanine (GUA), amorphous GUA is utilized to enhance its solubility, facilitating its transport for the formation of biominerals, and GUA nanocrystals are employed to protect tissues from ultraviolet damage.
Yuhang Liu, Ziqing Wu, Fenghua Chen, Yongming Liu, Rongrong Xue   +4 more
doaj   +1 more source