Results 51 to 60 of about 649 (170)
Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods
Chirality, Volume 38, Issue 7, July 2026.Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz +1 more
wiley +1 more source
Synthesis, characterization, and stability study of desloratadine multicomponent crystal formation
Research in Pharmaceutical Sciences, 2018 This study describes the formation of multicomponent crystal (MCC) of desloratadine (DES). The objective of this study was to discover the new pharmaceutical MCC of DES using several coformers. The MCC synthesis was performed between DES and 26 coformers
Ahmad Ainurofiq +3 more
doaj +1 more source
Annals of Medicine, 2021 Introduction Strategies to address the problem of poorly water-soluble drugs encompass the conversion of a crystalline drug into an amorphous form to promote its apparent solubility and dissolution.
Ana C. Bastos +3 more
doaj +1 more source
Crystal Research and Technology, Volume 61, Issue 7, July 2026.Naringin and naringenin exhibit well‐recognized therapeutic potential; however, they face limitations related to solubility and bioavailability. Micronization increases surface area and enhances absorption. Notably, cocrystallization stands out as a primary strategy for particle optimization, as it refines physicochemical properties, improves ...
Emilia Rodrigues Almeida +4 more
wiley +1 more source
Acta Crystallographica Section E: Crystallographic Communications, 2021 Ionic co-crystals are co-crystals between organic molecules and inorganic salt coformers. Co-crystals of pharmaceuticals are of interest to help control polymorph formation and potentially improve stability and other physical properties.
Elizabeth Tinapple +2 more
doaj +1 more source
Propellants, Explosives, Pyrotechnics, Volume 51, Issue 7, Page 1044-1057, July 2026.Ammonium dinitramide (ADN) and 3,4‐Diaminofurazan (DAF) form a 1:1 energetic cocrystal. We report its crystal structure and spectroscopic signature and evaluate thermal stability, decomposition behavior, hygroscopicity, and combustion properties. Propellant performance calculations benchmark the material against guanylurea dinitramide (GuDN) and ...
Peter Schultz +2 more
wiley +1 more source
Hittite Journal of Science and Engineering, 2019 Two co-crystals of p-aminobenzoic acid with isonicotinamide and pyrazine were prepared in acetone-ethanol solution by solvent evaporation method in the 1:1 cytochiometric ratio.
Fureya Elif Ozbek
doaj +1 more source
Crystal Engineering of Ionic Cocrystals Sustained by Azolium···Azole Heterosynthons
Pharmaceutics, 2022 Crystal engineering of multi-component molecular crystals, cocrystals, is a subject of growing interest, thanks in part to the potential utility of pharmaceutical cocrystals as drug substances with improved properties. Whereas molecular cocrystals (MCCs)
Maryam Rahmani +3 more
doaj +1 more source
Systematic coformer contribution to cocrystal stabilization: energy and packing trends
CrystEngComm, 2020 CSD data mining and energy calculations show that coformer self-interactions might significantly contribute to the packing energy stabilization of cocrystals.
Mazzeo P. P. +4 more
openaire +3 more sources
Chemistry, 2023 Structures of three cocrystals of nootropic racetams were studied. They included two cocrystals of phenylpiracetam (PPA) with 4-hydroxybenzoic acid (HBA) with different stoichiometries, PPA·HBA and PPA·2HBA, and cocrystal of 2-(4-phenyl-2-oxopyrrolidin-1-
Jason Marquez +6 more
doaj +1 more source