Results 51 to 60 of about 1,361 (189)
Enhancing Febuxostat Solubility Through Cocrystal Formation: Role of Substrate Selection and Amide Coformers. [PDF]
Int J Mol SciSolubility plays a crucial role in drug bioavailability and therapeutic efficacy. Febuxostat (FEB), a BCS Class II drug used to treat hyperuricemia and gout, has low solubility, limiting its effectiveness.
Pindelska E +4 more
europepmc +2 more sources
Predicting and Rationalizing Piezoelectricity in Racemic Bioorganic Molecular Crystals
Angewandte Chemie, Volume 138, Issue 26, 22 June 2026.Racemic molecular crystals, composed of equal mixtures of chiral enantiomeric components, are predicted to exhibit significant piezoelectric responses and favourable mechanical flexibility. This study identifies organic and bioorganic racemates as promising candidates for sustainable, lead‐free materials, enabling next‐generation applications in energy
Shubham Vishnoi, Sarah Guerin
wiley +2 more sources
On the rational topological complexity of coformal elliptic spaces
Journal of Pure and Applied Algebra, 2023 We establish some upper and lower bounds of the rational topological complexity for certain classes of elliptic spaces. Our techniques permit us in particular to show that the rational topological complexity coincides with the dimension of the rational homotopy for some special families of coformal elliptic spaces.
Hamoun, Said +2 more
openaire +4 more sources
Oxalic Acid, a Versatile Coformer for Multicomponent Forms with 9-Ethyladenine [PDF]
Crystals, 2022 Six new multicomponent solids of 9-ethyladenine and oxalic acid have been detected and characterized. The salt screening has been performed by mechanochemical and solvent crystallization processes. Single crystals of the anhydrous salts in 1:1 and 2:1 nucleobase:coformer molar ratio were obtained by solution crystallization and elucidated by single ...
Mónica Benito +3 more
openaire +3 more sources
Pharmaceutical Cocrystal of Piroxicam: Design, Formulation and Evaluation [PDF]
Advanced Pharmaceutical Bulletin, 2017 Purpose: Cocrystallisation of drug with coformers is a promising approach to alter the solid sate properties of drug substances like solubility and dissolution.
Prabhakar Panzade +3 more
doaj +1 more source
, 2018 The multiparameter model comprising 1D and 2D QSPR/QSAR descriptors was proposed and validated for phenolic acid binary systems. This approach is based on the optimization of regression coefficients for maximization of the percentage of true positives
Maciej Przybyłek (4270885) +1 more
core +3 more sources
Cocrystallization of acetaminophen and glutaric acid with different coformers [PDF]
Acta Crystallographica Section A Foundations and Advances, 2014 Recently cocrystallization became a popular tool for crystal engineering that allows, for instance, improving properties of pharmaceutical materials, creating new materials for nonlinear optical applications and solar cell technologies. To attract students to crystallographic studies we carried out project that included crystal growth of two series of ...
Tatiana Timofeeva +5 more
openaire +1 more source
Recent advances in improving oral drug bioavailability by cocrystals [PDF]
BioImpacts, 2018 Introduction: Oral drug delivery is the most favored route of drug administration. However, poor oral bioavailability is one of the leading reasons for insufficient clinical efficacy.
Shahram Emami +3 more
doaj +1 more source
Thermally Stable and Insensitive Energetic Cocrystals Comprising Nitrobarbituric Acid Coformers
, 2023 Four novel energetic cocrystals of 5-nitropyrimidine-2,4,6(1H,3H,5H)-trione/nitro barbituric acid (NBA) with energetic coformers 1H-tetrazol-5-amine (AmTz), 5-(4-nitro-1H-pyrazol-3-yl)-4H-1,2,4-triazol-3-amine (NPTA), 1,3-diaminoguanidinehydrochloride ...
Abhishek Kumar Yadav (14013460) +2 more
core +1 more source
Annals of Medicine, 2021 Introduction Strategies to address the problem of poorly water-soluble drugs encompass the conversion of a crystalline drug into an amorphous form to promote its apparent solubility and dissolution.
Ana C. Bastos +3 more
doaj +1 more source