Results 31 to 40 of about 1,361 (189)
Crystals, 2022 Developing multicomponent crystal forms, especially cocrystals and salts, is becoming a promising pathway to improve the solubility and bioavailability of drugs.
Yujiang Xie +8 more
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Coformational Switch of Oligonucleotide Induced by Spermine [PDF]
Nucleic Acids Symposium Series, 2005 Conformational change of nucleic acids induced by a small molecule is essential for many biological reactions and useful for biotechnology. To construct a spermine-responsive nucleic acid, we designed DNA sequences which can potentially form a unimolecular hairpin loop structure and a bimolecular duplex by itself.
Toshimasa, Kirihata +6 more
openaire +2 more sources
Temozolomide Cocrystals with Carboxamide Coformers
, 2016 Temozolomide (TMZ) is an antitumor prodrug of broad spectrum antineoplastic activity. TMZ is stable in acidic medium (pH < 4) but starts to decompose at alkaline pH (>7).
Ashwini Nangia (1400761) +2 more
core +3 more sources
Dissolution Enhancement of Atorvastatin Calcium by Cocrystallization [PDF]
Advanced Pharmaceutical Bulletin, 2019 Purpose: To enhance the dissolution rate of the poorly soluble drug atorvastatin calcium (ATC) by cocrystallization with selected coformers. Enhancement of the dissolution rate and solubility of the drug, which is classified as Class II of the ...
Reham Al-Kazemi +2 more
doaj +1 more source
Utilizing hot-stage polarized microscopy and ATR-FTIR for ramipril co-crystal screening, supported by principal component analysis and cluster analysis [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2023 Context: Co-crystal formation, a method for enhancing the physicochemical properties of active pharmaceutical ingredients (APIs), has gained traction in pharmaceutical research. However, the current landscape lacks comprehensive and dependable co-crystal
Indra Indra +5 more
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Crystals, 2020 The cocrystal formation of pharmaceuticals can improve the various physical properties of drugs, such as solubility, without the need for chemical modification of the drug substances.
Maho Urano +6 more
doaj +1 more source
Pharmaceutics, 2022 Formation thermodynamic parameters for three cocrystals of carbamazepine (CBZ) with structurally related coformers (benzamide (BZA), para-hydroxybenzamide (4-OH-BZA) and isonicotinamide (INAM)) were determined by experimental (cocrystal solubility and ...
Alex N. Manin +5 more
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Differences in Coformer Interactions of the 2,4-Diaminopyrimidines Pyrimethamine and Trimethoprim
Crystal Growth & Design, 2022 The identification and study of supramolecular synthons is a fundamental task in the design of pharmaceutical cocrystals. The malaria drug pyrimethamine (pyr) and the antibiotic trimethoprim (tmp) are both 2,4-diaminopyrimidine derivatives, providing the same C–NH2/N═C/C–NH2 and C–NH2/N═C interaction sites.
Lamis Alaa Eldin Refat +4 more
openaire +3 more sources
Differential scanning calorimetry: A screening tool for the development of diacerein eutectics
Results in Chemistry, 2022 The application of DSC technique has been employed for better understanding the behavior of multi-component solid forms of poorly water-soluble drugs. Therefore, the purpose of the present work was to investigate the binary system of Diacerein (DIC) by ...
Rajeshri D. Patel, Mihir K. Raval
doaj +1 more source
Nature Communications, 2021 Experimental determination of new cocrystals remains challenging due to the need of a systematic screening with a large range of coformers. Here the authors develop a flexible deep learning framework based on graph neural network demonstrated to quickly ...
Yuanyuan Jiang +7 more
doaj +1 more source