Results 31 to 40 of about 649 (170)
Solubility enhancement of carvedilol by multicomponent crystal approach using glycine and arginine as coformers [PDF]
Pharmacia, 2023 A Carvedilol is a member of BCS class II, it has a low solubility and bioavailability. This work intends to increase the solubility of carvedilol using a multicomponent crystal method.
Iyan Sopyan +3 more
doaj +3 more sources
Rational Coformer or Solvent Selection for Pharmaceutical Cocrystallization or Desolvation [PDF]
Journal of Pharmaceutical Sciences, 2012 It is demonstrated that the fluid-phase thermodynamics theory conductor-like screening model for real solvents (COSMO-RS) as implemented in the COSMOtherm software can be used for accurate and efficient screening of coformers for active pharmaceutical ingredient (API) cocrystallization.
Abramov, Yuriy A. +2 more
openaire +2 more sources
Cocrystallization approach: Dissolution rate enhancement of carbamazepine with various coformers and virtual screening tools [PDF]
Journal of Pharmacy & Pharmacognosy ResearchContext: Cocrystallization is a promising solid-state modification used to enhance the dissolution rate and solubility of poorly water-soluble drugs, such as carbamazepine.
Taofik Rusdiana +3 more
doaj +1 more source
Efficient Screening of Coformers for Active Pharmaceutical Ingredient Cocrystallization
Crystal Growth & Design, 2022 Controlling the physical properties of solid forms for active pharmaceutical ingredients (APIs) through cocrystallization is an important part of drug product development. However, it is difficult to know a priori which coformers will form cocrystals with a given API, and the current state-of-the-art for cocrystal discovery involves an expensive, time ...
Isaac J. Sugden +4 more
openaire +2 more sources
Oxalic Acid, a Versatile Coformer for Multicomponent Forms with 9-Ethyladenine [PDF]
Crystals, 2022 Six new multicomponent solids of 9-ethyladenine and oxalic acid have been detected and characterized. The salt screening has been performed by mechanochemical and solvent crystallization processes. Single crystals of the anhydrous salts in 1:1 and 2:1 nucleobase:coformer molar ratio were obtained by solution crystallization and elucidated by single ...
Mónica Benito +3 more
openaire +3 more sources
Pharmaceutical Cocrystal of Piroxicam: Design, Formulation and Evaluation [PDF]
Advanced Pharmaceutical Bulletin, 2017 Purpose: Cocrystallisation of drug with coformers is a promising approach to alter the solid sate properties of drug substances like solubility and dissolution.
Prabhakar Panzade +3 more
doaj +1 more source
On the rational topological complexity of coformal elliptic spaces
Journal of Pure and Applied Algebra, 2023 We establish some upper and lower bounds of the rational topological complexity for certain classes of elliptic spaces. Our techniques permit us in particular to show that the rational topological complexity coincides with the dimension of the rational homotopy for some special families of coformal elliptic spaces.
Hamoun, Said +2 more
openaire +3 more sources
Crystals, 2022 In this investigation, three new crystal forms of lidocaine, and another three of lidocaine hydrochloride with hydroquinone, resorcinol, and pyrogallol were synthetised.
Cristóbal Verdugo-Escamilla +5 more
doaj +1 more source
Predicting and Rationalizing Piezoelectricity in Racemic Bioorganic Molecular Crystals
Angewandte Chemie, Volume 138, Issue 26, 22 June 2026.Racemic molecular crystals, composed of equal mixtures of chiral enantiomeric components, are predicted to exhibit significant piezoelectric responses and favourable mechanical flexibility. This study identifies organic and bioorganic racemates as promising candidates for sustainable, lead‐free materials, enabling next‐generation applications in energy
Shubham Vishnoi, Sarah Guerin
wiley +2 more sources
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2023 Cocrystallization is an emerging approach for improving physico-chemical characteristics of an active pharmaceutical ingredient (API) for instance dissolution rate, solubility, stability in addition to mechanical properties without affecting their ...
Ameera A Radhi +3 more
doaj +1 more source