Results 21 to 30 of about 649 (170)
Differences in Coformer Interactions of the 2,4-Diaminopyrimidines Pyrimethamine and Trimethoprim
Crystal Growth & Design, 2022 The identification and study of supramolecular synthons is a fundamental task in the design of pharmaceutical cocrystals. The malaria drug pyrimethamine (pyr) and the antibiotic trimethoprim (tmp) are both 2,4-diaminopyrimidine derivatives, providing the same C–NH2/N═C/C–NH2 and C–NH2/N═C interaction sites.
Lamis Alaa Eldin Refat +4 more
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Differential scanning calorimetry: A screening tool for the development of diacerein eutectics
Results in Chemistry, 2022 The application of DSC technique has been employed for better understanding the behavior of multi-component solid forms of poorly water-soluble drugs. Therefore, the purpose of the present work was to investigate the binary system of Diacerein (DIC) by ...
Rajeshri D. Patel, Mihir K. Raval
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Pre-Activation as a Route for Tuning the Kinetics of Mechanochemical Transformations. [PDF]
Angew Chem Int Ed EnglThe kinetics of mechanochemical reactions can be markedly altered through the selective pre‐activation of starting reagents, as revealed through reaction monitoring using time‐resolved in situ powder X‐ray diffraction and ab initio density functional theory simulation.
Heinekamp C +7 more
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IUCrJ, 2016 A novel design strategy for cocrystals of a sulfonamide drug with pyridine carboxamides and cyclic amides is developed based on synthon identification as well as size and shape match of coformers.
Geetha Bolla, Ashwini Nangia
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Nature Communications, 2021 Experimental determination of new cocrystals remains challenging due to the need of a systematic screening with a large range of coformers. Here the authors develop a flexible deep learning framework based on graph neural network demonstrated to quickly ...
Yuanyuan Jiang +7 more
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Virtual Screening, Structural Analysis, and Formation Thermodynamics of Carbamazepine Cocrystals
Pharmaceutics, 2023 In this study, the existing set of carbamazepine (CBZ) cocrystals was extended through the successful combination of the drug with the positional isomers of acetamidobenzoic acid.
Artem O. Surov +5 more
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Engineering Cocrystals of Poorly Water-Soluble Drugs to Enhance Dissolution in Aqueous Medium
Pharmaceutics, 2018 Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and cannot be developed into a pharmaceutical formulation due to their poor aqueous ...
Indumathi Sathisaran +1 more
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Pharmaceutical Cocrystals: New Solid Phase Modification Approaches for the Formulation of APIs
Pharmaceutics, 2018 Cocrystals can be used as an alternative approach based on crystal engineering to enhance specific physicochemical and biopharmaceutical properties of active pharmaceutical ingredients (APIs) when the approaches to salt or polymorph formation do not meet
Anna Karagianni +2 more
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Cocrystallization of gliclazide with improved physicochemical properties
Future Journal of Pharmaceutical Sciences, 2021 Background Cocrystallization is one of the crystal engineering strategies used to alter the physicochemical properties of drugs that are poorly water-soluble.
Shivarani Eesam +3 more
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Coformality around fibrations and cofibrations
Homology, Homotopy and Applications, 2023 We show that in a fibration the coformality of the base space implies the coformality of the total space under reasonable conditions, and these conditions can not be weakened. The result is partially dual to the classical work of Lupton \cite{Lup} on the formality within a fibration. Our result has two applications.
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