Solubility improvement of atorvastatin using deep eutectic solvents [PDF]
Journal of Advanced Pharmaceutical Technology & ResearchDeep eutectic solvents (DESs) in pharmaceutical investigations are still largely unknown in terms of safety, environmental acceptability, and practical use.
Yoga Windhu Wardhana +2 more
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Pre-Activation as a Route for Tuning the Kinetics of Mechanochemical Transformations. [PDF]
Angew Chem Int Ed EnglThe kinetics of mechanochemical reactions can be markedly altered through the selective pre‐activation of starting reagents, as revealed through reaction monitoring using time‐resolved in situ powder X‐ray diffraction and ab initio density functional theory simulation.
Heinekamp C +7 more
europepmc +2 more sources
Enhancing water solubility of phytosterols through Co-amorphization with food-grade coformers [PDF]
Current Research in Food SciencePhytosterols (PS) offer significant health benefits in human diet, but its poor solubility limits its effectiveness and application. This study explored enhancing PS solubility by testing thirteen food-grade coformers, three preparation methods and ...
Yuxin Li +7 more
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Multicomponent crystals: Solubility enhancement of simvastatin using arginine and glycine coformers [PDF]
Journal of Pharmacy & Pharmacognosy ResearchContext: Simvastatin can be modified by the formation of multicomponent crystals to increase its solubility. Aims: To compare the solubility of multicomponent simvastatin crystals to pure simvastatin. Methods: The in silico study of simvastatin and
Iyan Sopyan +3 more
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Machine learning analysis of pharmaceutical cocrystals solubility parameters in enhancing the drug properties for advanced pharmaceutical manufacturing [PDF]
Scientific ReportsA new computational framework based on machine learning was developed for prediction of Hansen solubility parameters in preparation of pharmaceutical cocrystals with improved properties.
Tareq Nafea Alharby, Bader Huwaimel
doaj +2 more sources
Mechanochemical Syntheses of Isostructural Luminescent Cocrystals of 9-Anthracenecarboxylic Acid with two Dipyridines Coformers [PDF]
Crystals, 2020 Tuning and controlling the solid-state photophysical properties of organic luminophore are very important to develop next-generation organic luminescent materials.
Torvid Feiler +5 more
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In Silico Coformer Screening for Mefenamic Acid Cocrystallization
Jurnal Info KesehatanCocrystallization is a widely used approach to enhance the solubility and dissolution characteristics of poorly soluble drugs. A pharmaceutical cocrystal is a multicomponent system composed of a solid active pharmaceutical ingredient (API) and a coformer,
Aulia Fikri Hidayat +3 more
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Searching for Suitable Kojic Acid Coformers: From Cocrystals and Salt to Eutectics [PDF]
, 2023 The possibility of obtaining cocrystals of kojic acid with organic coformers has been investigated by both computational and experimental approaches. Cocrystallization attempts have been carried out with about 50 coformers, in different stoichiometric ...
Fabrizia Grepioni (1492783) +4 more
core +2 more sources
Novel Cocrystals of Vonoprazan: Machine Learning-Assisted Discovery
Pharmaceutics, 2022 Vonoprazan (VPZ) is the first-in-class potassium-competitive acid blocker (P-CAB), and has many advantages over proton pump inhibitors (PPIs). It is administered as a fumarate salt for the treatment of acid-related diseases, including reflux esophagitis,
Min-Jeong Lee +6 more
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Rational Coformer Selection in the Development of 6-Propyl-2-thiouracil Pharmaceutical Cocrystals
Pharmaceuticals, 2023 Pharmaceutical multicomponent solids have proved to efficiently modulate the physicochemical properties of active pharmaceutical ingredients. In this context, polyphenols are interesting coformers for designing pharmaceutical cocrystals due to their wide
Francisco Javier Acebedo-Martínez +7 more
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