Results 11 to 20 of about 649 (170)
A Review of Coformer Utilization in Multicomponent Crystal Formation
Molecules, 2022 Most recently discovered active pharmaceutical molecules and market-approved medicines are poorly soluble in water, resulting in limited drug bioavailability and therapeutic effectiveness.
Nasrul Wathoni +4 more
doaj +3 more sources
Cocrystals and Solvates are Not the Same: A Network Perspective. [PDF]
ChemphyschemBased on network analysis, cocrystals and solvates cannot be treated the same. Cocrystals and solvates are two kinds of multicomponent crystals. Cocrystals consist of solid compounds, while solvates consist of a mixture of solid and liquid compounds. This work addresses the question of whether cocrystals and solvates can be treated the same or need to ...
de Vries TE +3 more
europepmc +2 more sources
In Silico Coformer Screening for Mefenamic Acid Cocrystallization
Jurnal Info KesehatanCocrystallization is a widely used approach to enhance the solubility and dissolution characteristics of poorly soluble drugs. A pharmaceutical cocrystal is a multicomponent system composed of a solid active pharmaceutical ingredient (API) and a coformer,
Aulia Fikri Hidayat +3 more
doaj +2 more sources
Rational Coformer Selection in the Development of 6-Propyl-2-thiouracil Pharmaceutical Cocrystals
Pharmaceuticals, 2023 Pharmaceutical multicomponent solids have proved to efficiently modulate the physicochemical properties of active pharmaceutical ingredients. In this context, polyphenols are interesting coformers for designing pharmaceutical cocrystals due to their wide
Francisco Javier Acebedo-Martínez +7 more
doaj +1 more source
Coformational Switch of Oligonucleotide Induced by Spermine [PDF]
Nucleic Acids Symposium Series, 2005 Conformational change of nucleic acids induced by a small molecule is essential for many biological reactions and useful for biotechnology. To construct a spermine-responsive nucleic acid, we designed DNA sequences which can potentially form a unimolecular hairpin loop structure and a bimolecular duplex by itself.
Toshimasa, Kirihata +6 more
openaire +2 more sources
Dissolution Enhancement of Atorvastatin Calcium by Cocrystallization [PDF]
Advanced Pharmaceutical Bulletin, 2019 Purpose: To enhance the dissolution rate of the poorly soluble drug atorvastatin calcium (ATC) by cocrystallization with selected coformers. Enhancement of the dissolution rate and solubility of the drug, which is classified as Class II of the ...
Reham Al-Kazemi +2 more
doaj +1 more source
Screening of coformers for quercetin cocrystals through mechanochemical methods
Eclética Química, 2022 Quercetin (QUE) is a nutraceutical compound that exhibits pharmacological properties such as antioxidant, cardioprotective, anti-ulcer, and anti-inflammatory effects.
Fayene Zeferino Ribeiro de Souza +4 more
doaj +1 more source
Pharmaceutics, 2022 Formation thermodynamic parameters for three cocrystals of carbamazepine (CBZ) with structurally related coformers (benzamide (BZA), para-hydroxybenzamide (4-OH-BZA) and isonicotinamide (INAM)) were determined by experimental (cocrystal solubility and ...
Alex N. Manin +5 more
doaj +1 more source
Utilizing hot-stage polarized microscopy and ATR-FTIR for ramipril co-crystal screening, supported by principal component analysis and cluster analysis [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2023 Context: Co-crystal formation, a method for enhancing the physicochemical properties of active pharmaceutical ingredients (APIs), has gained traction in pharmaceutical research. However, the current landscape lacks comprehensive and dependable co-crystal
Indra Indra +5 more
doaj +1 more source
Crystals, 2020 The cocrystal formation of pharmaceuticals can improve the various physical properties of drugs, such as solubility, without the need for chemical modification of the drug substances.
Maho Urano +6 more
doaj +1 more source