Results 1 to 10 of about 1,361 (189)
Journal of Chemistry, 2021 Drug cocrystals and salts have promising applications for modulating the physicochemical properties and solubility of pharmaceuticals. In this study, a cocrystal and two salts of febuxostat (FEB) with pyridine nitrogen coformers, including 4, 4 ...
Lei Gao, Xianrui Zhang
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Virtual screening of coformers and solubility test for glibenclamide cocrystallization
National Journal of Physiology, Pharmacy and Pharmacology, 2018 Background: The therapeutic effectiveness of active pharmaceutical ingredients (API) depends on their solubility. API, which has poorly soluble drugs, can cause low bioavailability.
Arif Budiman +2 more
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Crystals, 2022 In this investigation, three new crystal forms of lidocaine, and another three of lidocaine hydrochloride with hydroquinone, resorcinol, and pyrogallol were synthetised.
Cristóbal Verdugo-Escamilla +5 more
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Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2023 Cocrystallization is an emerging approach for improving physico-chemical characteristics of an active pharmaceutical ingredient (API) for instance dissolution rate, solubility, stability in addition to mechanical properties without affecting their ...
Ameera A Radhi +3 more
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Crystals, 2018 The pre-formulation of pharmaceutical cocrystals and salts is a concept of crystal engineering that has emerged as a promising technique for drug development in pharmaceutical industry.
Ranjit Thakuria, Bipul Sarma
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Propellants, Explosives, Pyrotechnics, EarlyView.Ammonium dinitramide (ADN) and 3,4‐Diaminofurazan (DAF) form a 1:1 energetic cocrystal. We report its crystal structure and spectroscopic signature and evaluate thermal stability, decomposition behavior, hygroscopicity, and combustion properties. Propellant performance calculations benchmark the material against guanylurea dinitramide (GuDN) and ...
Peter Schultz +2 more
wiley +1 more source
Acta Crystallographica Section B, EarlyView.We describe a coformer selection tool that uses knowledge of functional group interactions found in the Cambridge Structural Database to quickly identify complementary molecules to the target.A new methodology to perform virtual coformer screening, utilising data gathered on hydrogen‐bonding interactions present in the organic subset of the Cambridge ...
Joanna S. Stevens +2 more
wiley +1 more source
Synthesis, characterization, and stability study of desloratadine multicomponent crystal formation
Research in Pharmaceutical Sciences, 2018 This study describes the formation of multicomponent crystal (MCC) of desloratadine (DES). The objective of this study was to discover the new pharmaceutical MCC of DES using several coformers. The MCC synthesis was performed between DES and 26 coformers
Ahmad Ainurofiq +3 more
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Multicomponent Solids of Niflumic and Mefenamic Acids Based on Acid-Pyridine Synthon
Frontiers in Chemistry, 2022 The present study discusses comparative structural features of fourteen multicomponent solids of two non-steroidal anti-inflammatory drugs, Niflumic and Mefenamic acids, with amine and pyridine-based coformers.
Vineet Kumar +5 more
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Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods
Chirality, Volume 38, Issue 7, July 2026.Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz +1 more
wiley +1 more source