IUCrJ, 2016 A novel design strategy for cocrystals of a sulfonamide drug with pyridine carboxamides and cyclic amides is developed based on synthon identification as well as size and shape match of coformers.
Geetha Bolla, Ashwini Nangia
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Engineering Cocrystals of Poorly Water-Soluble Drugs to Enhance Dissolution in Aqueous Medium
Pharmaceutics, 2018 Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and cannot be developed into a pharmaceutical formulation due to their poor aqueous ...
Indumathi Sathisaran +1 more
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Virtual Screening, Structural Analysis, and Formation Thermodynamics of Carbamazepine Cocrystals
Pharmaceutics, 2023 In this study, the existing set of carbamazepine (CBZ) cocrystals was extended through the successful combination of the drug with the positional isomers of acetamidobenzoic acid.
Artem O. Surov +5 more
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Pharmaceutical Cocrystals: New Solid Phase Modification Approaches for the Formulation of APIs
Pharmaceutics, 2018 Cocrystals can be used as an alternative approach based on crystal engineering to enhance specific physicochemical and biopharmaceutical properties of active pharmaceutical ingredients (APIs) when the approaches to salt or polymorph formation do not meet
Anna Karagianni +2 more
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Structural landscape of α-acetamidocinnamic acid cocrystals with bipyridine-based coformers : influence of crystal packing on their thermal and photophysical properties [PDF]
Altres ajuts: acords transformatius de la UABControlling the supramolecular synthon outcome in systems with different functionalities has been a key factor for the design of supramolecular materials, which also affected their physicochemical properties ...
Ejarque, Daniel +3 more
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Cocrystallization of gliclazide with improved physicochemical properties
Future Journal of Pharmaceutical Sciences, 2021 Background Cocrystallization is one of the crystal engineering strategies used to alter the physicochemical properties of drugs that are poorly water-soluble.
Shivarani Eesam +3 more
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Solubility enhancement of carvedilol by multicomponent crystal approach using glycine and arginine as coformers [PDF]
Pharmacia, 2023 A Carvedilol is a member of BCS class II, it has a low solubility and bioavailability. This work intends to increase the solubility of carvedilol using a multicomponent crystal method.
Iyan Sopyan +3 more
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Coformality around fibrations and cofibrations
Homology, Homotopy and Applications, 2023 We show that in a fibration the coformality of the base space implies the coformality of the total space under reasonable conditions, and these conditions can not be weakened. The result is partially dual to the classical work of Lupton \cite{Lup} on the formality within a fibration. Our result has two applications.
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Cocrystallization approach: Dissolution rate enhancement of carbamazepine with various coformers and virtual screening tools [PDF]
Journal of Pharmacy & Pharmacognosy ResearchContext: Cocrystallization is a promising solid-state modification used to enhance the dissolution rate and solubility of poorly water-soluble drugs, such as carbamazepine.
Taofik Rusdiana +3 more
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Rational Coformer or Solvent Selection for Pharmaceutical Cocrystallization or Desolvation [PDF]
Journal of Pharmaceutical Sciences, 2012 It is demonstrated that the fluid-phase thermodynamics theory conductor-like screening model for real solvents (COSMO-RS) as implemented in the COSMOtherm software can be used for accurate and efficient screening of coformers for active pharmaceutical ingredient (API) cocrystallization.
Abramov, Yuriy A. +2 more
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