Results 41 to 50 of about 649 (170)

Virtual screening of coformers and solubility test for glibenclamide cocrystallization

National Journal of Physiology, Pharmacy and Pharmacology, 2018
Background: The therapeutic effectiveness of active pharmaceutical ingredients (API) depends on their solubility. API, which has poorly soluble drugs, can cause low bioavailability.
Arif Budiman, Sandra Megantara, Ayu Apriliani   +2 more
doaj   +1 more source

Drug‑Drug and Drug‑Nutraceutical Cocrystal/Salt as Alternative Medicine for Combination Therapy: A Crystal Engineering Approach

Crystals, 2018
The pre-formulation of pharmaceutical cocrystals and salts is a concept of crystal engineering that has emerged as a promising technique for drug development in pharmaceutical industry.
Ranjit Thakuria, Bipul Sarma
doaj   +1 more source

Cocrystallization of Febuxostat with Pyridine Coformers: Crystal Structural and Physicochemical Properties Analysis

Journal of Chemistry, 2021
Drug cocrystals and salts have promising applications for modulating the physicochemical properties and solubility of pharmaceuticals. In this study, a cocrystal and two salts of febuxostat (FEB) with pyridine nitrogen coformers, including 4, 4 ...
Lei Gao, Xianrui Zhang
doaj   +1 more source

Properadic coformality of spheres

International Mathematics Research Notices
Abstract We define a properad $\mathcal{Y}^{(n)}_\infty $ that encodes $n$-pre-Calabi–Yau algebras with vanishing copairing. These algebras include chains on the based loop space of any space $X$ endowed with a fundamental class $[X]$ such that $(X,[X])$ satisfies Poincaré duality of degree $n \geqslant 1$ with local system ...
Emprin, Coline, Takeda, Alex
openaire   +2 more sources

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Cocrystallization of acetaminophen and glutaric acid with different coformers [PDF]

Acta Crystallographica Section A Foundations and Advances, 2014
Recently cocrystallization became a popular tool for crystal engineering that allows, for instance, improving properties of pharmaceutical materials, creating new materials for nonlinear optical applications and solar cell technologies. To attract students to crystallographic studies we carried out project that included crystal growth of two series of ...
Tatiana Timofeeva, Sofia Antal, Sergiu Draguta, Karla Ordonez, Raul Castaneda, Evgeniya Leonova   +5 more
openaire   +1 more source

Interaction Analysis using the Cambridge Structural Database – rapid access to intermolecular hydrogen‐bond frequencies and uses for coformer selection

Acta Crystallographica Section B, EarlyView.
We describe a coformer selection tool that uses knowledge of functional group interactions found in the Cambridge Structural Database to quickly identify complementary molecules to the target.A new methodology to perform virtual coformer screening, utilising data gathered on hydrogen‐bonding interactions present in the organic subset of the Cambridge ...
Joanna S. Stevens, Andrew G. P. Maloney, Elna Pidcock   +2 more
wiley   +1 more source

Multicomponent Solids of Niflumic and Mefenamic Acids Based on Acid-Pyridine Synthon

Frontiers in Chemistry, 2022
The present study discusses comparative structural features of fourteen multicomponent solids of two non-steroidal anti-inflammatory drugs, Niflumic and Mefenamic acids, with amine and pyridine-based coformers.
Vineet Kumar, Pramod Kumar Goswami, Balendra, Balendra, Shailabh Tewari, Arunachalam Ramanan   +5 more
doaj   +1 more source

Effect of molecular perturbation on cocrystal formation: theophylline and its 8‐halo analogues with flavonoids

Acta Crystallographica Section C, Volume 82, Issue 8, Page 414-426, August 2026.
The tendency for alkaloid–flavonoid cocrystal formation is found to be markedly different for theophylline (Tph) compared to its 8‐halo analogues. Through screening with 13 common flavonoids, Tph is found to form cocrystals with six flavonoids, whereas 8‐Cl‐Tph and 8‐Br‐Tph each form cocrystals with just two, myricetin and kaempferol.
Weijian Ye, Herman H-Y. Sung, Ian D. Williams   +2 more
wiley   +1 more source

Recent advances in improving oral drug bioavailability by cocrystals [PDF]

BioImpacts, 2018
Introduction: Oral drug delivery is the most favored route of drug administration. However, poor oral bioavailability is one of the leading reasons for insufficient clinical efficacy.
Shahram Emami, Mohammadreza Siahi-Shadbad, Khosro Adibkia, Mohammad Barzegar-Jalali   +3 more
doaj   +1 more source