Results 41 to 50 of about 32,161 (285)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The genetic relationship between Alune, Lisabata, Luhu, and Wemale (Western Seram, Indonesia): a historical-comparative linguistics approach

Cogent Arts & Humanities
Language and cultural identity differences can easily lead to a small amount of warfare and confrontation due to a lack of sense of belonging. This study examined the genetic relationship of four languages spoken in Western Seram, consisting of the Alune,
Hendrokumoro, Faradika Darman, Neni Nuraeni, Nadia Khumairo Ma’shumah   +3 more
doaj   +1 more source

The Effect of Cognates on Cognitive Control in Late Sequential Multilinguals: A Bilingual Advantage?

Behavioral Sciences, 2019
The present study investigated the influence of Dutch-German cognates resp. orthographic neighbors on controlled language processing (i.e., response inhibition).
Jorik Fidler, Katja Lochtman
doaj   +1 more source

Hawaiian Picture‐Winged Drosophila Exhibit Adaptive Population Divergence along a Narrow Climatic Gradient on Hawaii Island [PDF]

, 2019
1. Anthropogenic influences on global processes and climatic conditions are increasingly affecting ecosystems throughout the world. 2. Hawaii Island’s native ecosystems are well studied and local long‐term climatic trends well documented, making these ...
Bellinger, M. Renee, Eldon, Jon, Price, Donald K.   +2 more
core   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Japanese aru, iru, oru 'to be' : [oru ist bin aru] [PDF]

, 2010
Among the Japanese expressions for 'to be', the verbs aru (unmarked), iru (animate subject) and oru (humble variant of iru) are of special interest (cf. Martin 1975: 194f. for a descriptive account). We may look for cognates of these verbs in the (other)
Kortlandt, Frederik H. H.
core  

Using Global Constraints and Reranking to Improve Cognates Detection

, 2017
Global constraints and reranking have not been used in cognates detection research to date. We propose methods for using global constraints by performing rescoring of the score matrices produced by state of the art cognates detection systems.
Bloodgood, Michael, Strauss, Benjamin
core   +1 more source

Structural insights into cognate versus near‐cognate discrimination during decoding [PDF]

The EMBO Journal, 2011
The structural basis of the tRNA selection process is investigated by cryo-electron microscopy of ribosomes programmed with UGA codons and incubated with ternary complex (TC) containing the near-cognate Trp-tRNA(Trp) in the presence of kirromycin. Going through more than 350 000 images and employing image classification procedures, we find ∼8% in which
Xabier, Agirrezabala, Eduard, Schreiner, Leonardo G, Trabuco, Jianlin, Lei, Rodrigo F, Ortiz-Meoz, Klaus, Schulten, Rachel, Green, Joachim, Frank   +7 more
openaire   +2 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source