Results 91 to 100 of about 538,409 (298)

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Cortical representations of affective pain shape empathic fear in male mice

Nature Communications
Affect sharing, the ability to vicariously feel others’ emotions, constitutes the primary component of empathy. However, the neural basis for encoding others’ distress and representing shared affective experiences remains poorly understood.
Jiye Choi, Young-Beom Lee, Dahm So, Jee Yeon Kim, Sungjoon Choi, Sowon Kim, Sehoon Keum   +6 more
doaj   +1 more source

Direct Electrophysiological Mapping of Shape-Induced Affective Perception

Neural Plasticity, 2018
Visual information may convey different affective valences and induce our brain into different affective perceptions. Many studies have found that unpleasant stimuli could produce stronger emotional effects than pleasant stimuli could. Although there has
Yingli Li, Qingguo Ding, Yuancun Zhao, Yanan Bu, Xiaoyan Tang, Peiguo Wang, Genhua Zhang, Mengling Chen, Pei Liang   +8 more
doaj   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Author Correction: Oscillatory dynamics underlying noun and verb production in highly proficient bilinguals

Scientific Reports, 2023
Shuang Geng, Nicola Molinaro, Polina Timofeeva, Ileana Quiñones, Manuel Carreiras, Lucia Amoruso   +5 more
doaj   +1 more source

Pre-saccadic Attention (and not Arousal) modulates the Size-Eccentricity Effect

Scientific Reports
Peripherally located objects are often perceived to be smaller than centrally located objects. This perceptual phenomenon, known as the Size-Eccentricity Effect (SEE), is mainly due to the structural properties of the visual system and is further ...
Jad Laaboudi, Anne Hillairet de Boisferon, Céline Paeye   +2 more
doaj   +1 more source

A distinction between two instruments measuring dispositional mindfulness and the correlations between those measurements and the neuroanatomical structure

Scientific Reports, 2017
The most widely used measurements of mindfulness are the Mindful Attention Awareness Scale (MAAS) and the Five Facet Mindfulness Questionnaire (FFMQ). However, controversies exist regarding the application of these scales.
Kaixiang Zhuang, Minghua Bi, Yu Li, Yunman Xia, Xuehua Guo, Qunlin Chen, Xue Du, Kangcheng Wang, Dongtao Wei, Huazhan Yin, Jiang Qiu   +10 more
doaj   +1 more source

the social organization of space: class, cognition, and residence in a Spanish town [PDF]

, 1977
David D. Gilmore
openalex   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source