Results 91 to 100 of about 2,085,476 (385)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Generating normative data from web-based administration of the Cambridge Neuropsychological Test Automated Battery using a Bayesian framework

Frontiers in Digital Health
IntroductionNormative cognitive data can distinguish impairment from healthy cognitive function and pathological decline from normal ageing. Traditional methods for deriving normative data typically require extremely large samples of healthy participants,
Elizabeth Wragg, Caroline Skirrow, Caroline Skirrow, Pasquale Dente, Jack Cotter, Peter Annas, Peter Annas, Milly Lowther, Milly Lowther, Rosa Backx, Jenny Barnett, Jenny Barnett, Fiona Cree, Jasmin Kroll, Francesca Cormack   +14 more
doaj   +1 more source

Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease

JAMA Neurology, 2019
Key Points Question Is cognitive decline associated with amyloid-β or tau tangles accumulation? Findings In this cohort study that included 60 normal older adults with repeated positron emission tomography measures, the rate of tau accumulation in the ...
Bernard J. Hanseeuw, Bernard J. Hanseeuw, R. Betensky, H. Jacobs, H. Jacobs, A. Schultz, J. Sepulcre, J. Becker, Danielle M. Cosio, Michelle E. Farrell, Y. Quiroz, E. Mormino, E. Mormino, R. Buckley, R. Buckley, R. Buckley, K. Papp, K. Papp, Rebecca Amariglio, Rebecca Amariglio, I. Dewachter, I. Dewachter, A. Ivanoiu, A. Ivanoiu, W. Huijbers, W. Huijbers, T. Hedden, G. Marshall, G. Marshall, J. Chhatwal, D. Rentz, D. Rentz, R. Sperling, R. Sperling, Keith A. Johnson, Keith A. Johnson   +35 more
semanticscholar   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Semantic associative abilities and executive control functions predict novelty and appropriateness of idea generation

Communications Biology
Novelty and appropriateness are two fundamental components of creativity. However, the way in which novelty and appropriateness are separated at behavioral and neural levels remains poorly understood.
Xueyang Wang, Qunlin Chen, Kaixiang Zhuang, Jingyi Zhang, Robert A. Cortes, Daniel D. Holzman, Li Fan, Cheng Liu, Jiangzhou Sun, Xianrui Li, Yu Li, Qiuyang Feng, Hong Chen, Tingyong Feng, Xu Lei, Qinghua He, Adam E. Green, Jiang Qiu   +17 more
doaj   +1 more source

Exploring the electrophysiological correlates of the default-mode network with intracerebral EEG

Frontiers in Systems Neuroscience, 2010
While functional imaging studies allow for a precise spatial characterization of resting state networks, their neural correlates and thereby their fine-scale temporal dynamics remain elusive.
Karim Jerbi, Karim Jerbi, Juan R Vidal, Juan R Vidal, Tomas Ossandon, Tomas Ossandon, Sarang S Dalal, Sarang S Dalal, Julien Jung, Julien Jung, Dominique Hoffmann, Lorella Minotti, Olivier Bertrand, Olivier Bertrand, Philippe Kahane, Jean-Philippe Lachaux, Jean-Philippe Lachaux   +16 more
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Dissecting task-based fMRI activity using normative modelling: an application to the Emotional Face Matching Task

Communications Biology
Functional neuroimaging has contributed substantially to understanding brain function but is dominated by group analyses that index only a fraction of the variation in these data.
Hannah S. Savage, Peter C. R. Mulders, Philip F. P. van Eijndhoven, Jasper van Oort, Indira Tendolkar, Janna N. Vrijsen, Christian F. Beckmann, Andre F. Marquand   +7 more
doaj   +1 more source

LIDA: A Working Model of Cognition [PDF]

, 2006
In this paper we present the LIDA architecture as a working model of cognition. We argue that such working models are broad in scope and address real world problems in comparison to experimentally based models which focus on specific pieces of cognition.
Baars, Bernard J., Franklin, Stan, Ramamurthy, Uma, S. K., D'Mello   +3 more
core  

The Theory and Neuroscience of Cerebellar Cognition.

Annual Review of Neuroscience, 2019
Cerebellar neuroscience has undergone a paradigm shift. The theories of the universal cerebellar transform and dysmetria of thought and the principles of organization of cerebral cortical connections, together with brain imaging studies and clinical ...
J. Schmahmann, X. Guell, Catherine J. Stoodley, M. Halko   +3 more
semanticscholar   +1 more source