Results 111 to 120 of about 2,177,617 (385)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

EARLY-LIFE CIRCUMSTANCES AND RACIAL DISPARITIES IN COGNITION AMONG US OLDER ADULTS [PDF]

, 2023
Zhuoer Lin, Justin Ye, Heather Allore, Thomas M. Gill, Xi Chen   +4 more
openalex   +1 more source

Community Lynching and the US Asthma Epidemic [PDF]

, 2003
We explore the implications of IR Cohen's work on immune cognition for understanding rising rates of asthma morbidity and mortality in the US. Immune cognition is inherently linked with central nervous system cognition, and with the cognitive function ...
Fullilove, Mindy, Wallace, Deborah, Wallace, Rodrick   +2 more
core  

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Tree shrews (tupaia belangeri) exhibit novelty preference in the novel location memory task with 24-hour retention periods.

Frontiers in Psychology, 2014
Novelty preference is pervasive in mammalian species, and describes an inherent tendency to preferentially explore novelty. The novel location memory task studied here assesses the ability of animals to form accurate memories of a spatial configuration,
Jayakrishnan H R Nair, Jayakrishnan H R Nair, Marlene eTopka, Marlene eTopka, Abbas eKhani, Abbas eKhani, Manuela eIsenschmid, Gregor eRainer, Gregor eRainer   +8 more
doaj   +1 more source

Explaining early moral hypocrisy: Numerical cognition promotes equal sharing behavior in preschool‐aged children [PDF]

, 2018
Nadia Chernyak, Paul L. Harris, Sara Cordes   +2 more
openalex   +1 more source

Cognition simulation and learning [PDF]

, 1980
The purpose of this paper is to describe new computer software that has been specifically developed to aid experiential learning in groups and with individuals.
Eden, Colin, Smithin, Tim, Wiltshire, Jim   +2 more
core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

The relationship between trait curiosity and cognitive reserve in younger and older adults

Scientific Reports
Understanding individual differences in cognitive reserve is key to predicting, and potentially influencing, factors that promote healthy cognitive aging.
Iris Wiegand, Isabel Donkers, Sebastian Balart-Sanchez, Marianna Pope, Gaspar Pérez-Ayora, Joukje M. Oosterman   +5 more
doaj   +1 more source