Results 61 to 70 of about 524,294 (267)

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Exploring the electrophysiological correlates of the default-mode network with intracerebral EEG

Frontiers in Systems Neuroscience, 2010
While functional imaging studies allow for a precise spatial characterization of resting state networks, their neural correlates and thereby their fine-scale temporal dynamics remain elusive.
Karim Jerbi, Karim Jerbi, Juan R Vidal, Juan R Vidal, Tomas Ossandon, Tomas Ossandon, Sarang S Dalal, Sarang S Dalal, Julien Jung, Julien Jung, Dominique Hoffmann, Lorella Minotti, Olivier Bertrand, Olivier Bertrand, Philippe Kahane, Jean-Philippe Lachaux, Jean-Philippe Lachaux   +16 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Tree shrews (tupaia belangeri) exhibit novelty preference in the novel location memory task with 24-hour retention periods.

Frontiers in Psychology, 2014
Novelty preference is pervasive in mammalian species, and describes an inherent tendency to preferentially explore novelty. The novel location memory task studied here assesses the ability of animals to form accurate memories of a spatial configuration,
Jayakrishnan H R Nair, Jayakrishnan H R Nair, Marlene eTopka, Marlene eTopka, Abbas eKhani, Abbas eKhani, Manuela eIsenschmid, Gregor eRainer, Gregor eRainer   +8 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Semantic associative abilities and executive control functions predict novelty and appropriateness of idea generation

Communications Biology
Novelty and appropriateness are two fundamental components of creativity. However, the way in which novelty and appropriateness are separated at behavioral and neural levels remains poorly understood.
Xueyang Wang, Qunlin Chen, Kaixiang Zhuang, Jingyi Zhang, Robert A. Cortes, Daniel D. Holzman, Li Fan, Cheng Liu, Jiangzhou Sun, Xianrui Li, Yu Li, Qiuyang Feng, Hong Chen, Tingyong Feng, Xu Lei, Qinghua He, Adam E. Green, Jiang Qiu   +17 more
doaj   +1 more source

Generating normative data from web-based administration of the Cambridge Neuropsychological Test Automated Battery using a Bayesian framework

Frontiers in Digital Health
IntroductionNormative cognitive data can distinguish impairment from healthy cognitive function and pathological decline from normal ageing. Traditional methods for deriving normative data typically require extremely large samples of healthy participants,
Elizabeth Wragg, Caroline Skirrow, Caroline Skirrow, Pasquale Dente, Jack Cotter, Peter Annas, Peter Annas, Milly Lowther, Milly Lowther, Rosa Backx, Jenny Barnett, Jenny Barnett, Fiona Cree, Jasmin Kroll, Francesca Cormack   +14 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Cognition individuelle et cognition collective

Ingénierie Cognitique, 2020
Jean-Claude Sallaberry
doaj   +1 more source

Dissecting task-based fMRI activity using normative modelling: an application to the Emotional Face Matching Task

Communications Biology
Functional neuroimaging has contributed substantially to understanding brain function but is dominated by group analyses that index only a fraction of the variation in these data.
Hannah S. Savage, Peter C. R. Mulders, Philip F. P. van Eijndhoven, Jasper van Oort, Indira Tendolkar, Janna N. Vrijsen, Christian F. Beckmann, Andre F. Marquand   +7 more
doaj   +1 more source