Results 71 to 80 of about 248,196 (298)

Diffusion‐based size determination of solute particles: a method adapted for postsynaptic proteins

FEBS Open Bio, EarlyView.
We present a diffusion‐based approach for measuring the size of macromolecules and their complexes, and demonstrate its use on postsynaptic proteins. The method requires fluorescein‐labelled protein samples, a microfluidic device that maintains laminar flow for said samples, a microscope recording the emitted fluorescent signals, and an analytic ...
András László Szabó, Eszter Nagy‐Kanta, Soma Varga, Edit Andrea Jáger, Csaba István Pongor, Mária Laki, András József Laki, Zoltán Gáspári   +7 more
wiley   +1 more source

Hypoxia Augments Cerebral Inflammation in a Dextran Sulfate Sodium-Induced Colitis Mouse Model

Frontiers in Cellular Neuroscience, 2020
The importance of hypoxia in the pathophysiology of inflammatory bowel disease (IBD) is increasingly being realized; also, hypoxia seems to be an important accelerator of brain inflammation, as has been reported by our group and others.
Ying Han, Ying Han, Liping Ding, Xiang Cheng, Ming Zhao, Tong Zhao, Liang Guo, Xinyang Li, Yanan Geng, Yanan Geng, Ming Fan, Ming Fan, Hong Liao, Lingling Zhu, Lingling Zhu   +14 more
doaj   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Mapping subtype-specific disease epicenters and brain aging characteristics in major depressive disorder through normative model-driven analysis of brain structural alterations

NeuroImage
Major depressive disorder (MDD), a prevalent mental health condition, manifests intricate alterations in brain structure that evolve gradually over time and across various brain regions.
Peng Wang, Yuhong Zheng, Li Sun, Yang Xiao, Xuelian Zang, Jinghua Wang, Jinhui Wang, Shao-Wei Xue   +7 more
doaj   +1 more source

The role of conceptual knowledge in understanding synaesthesia: Evaluating contemporary findings from a ‘hub-and-spoke’ perspective

Frontiers in Psychology, 2014
Synaesthesia is a phenomenon in which stimulation in one sensory modality triggers involuntary experiences typically not associated with that stimulation.
Rocco eChiou, Rocco eChiou, Anina N Rich, Anina N Rich   +3 more
doaj   +1 more source

Differences in Cerebral Structure Associated With Depressive Symptoms in the Elderly With Alzheimer’s Disease

Frontiers in Aging Neuroscience, 2020
Background: Alzheimer’s disease (AD) is characterized by global deterioration in multiple cognitive domains. In addition to cognitive impairment, depressive symptoms are common issues that trouble AD patients.
Yue Wu, Yue Wu, Xingqi Wu, Xingqi Wu, Qiang Wei, Qiang Wei, Qiang Wei, Kai Wang, Kai Wang, Kai Wang, Kai Wang, Yanghua Tian, Yanghua Tian, Yanghua Tian, and the Alzheimer’s Disease Neuroimaging Initiative   +14 more
doaj   +1 more source

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

FEBS Open Bio, EarlyView.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell   +8 more
wiley   +1 more source

Exam‐level analysis of lecture capture viewing and student exam performance

FEBS Open Bio, EarlyView.
This study asks how lecture capture relates to exam performance in biology courses with three noncumulative exams. Mixed‐effects modeling separated between‐students from within‐student effects on exam %. Students who watched more recordings earned higher grades, but viewing spikes above a student's own mean, consistent with cramming, predicted small ...
Kirk Hillsley
wiley   +1 more source

Developmental disruption of amygdala transcriptome and socioemotional behavior in rats exposed to valproic acid prenatally

Molecular Autism, 2017
Background The amygdala controls socioemotional behavior and has consistently been implicated in the etiology of autism spectrum disorder (ASD). Precocious amygdala development is commonly reported in ASD youth with the degree of overgrowth positively ...
Catherine E. Barrett, Thomas M. Hennessey, Katelyn M. Gordon, Steve J. Ryan, Morgan L. McNair, Kerry J. Ressler, Donald G. Rainnie   +6 more
doaj   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source