Results 41 to 50 of about 994,859 (217)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Spatiotemporal hierarchies of face representation in the human ventral temporal cortex

Scientific Reports
In this study, we examined the relatively unexplored realm of face perception, investigating the activities within human brain face-selective regions during the observation of faces at both subordinate and superordinate levels.
Sina Salehi, Mohammad Reza A. Dehaqani, Jessica Schrouff, Clara Sava-Segal, Omri Raccah, Sori Baek   +5 more
doaj   +1 more source

Adjustable Robust Energy Operation Planning under Uncertain Renewable Energy Production

Energies
In this paper, the application of the method of affinely adjustable robust optimization to a planning model of an energy system under uncertain parameters is presented, and the total scheduling costs in comparison with the deterministic model are ...
Anna Eingartner, Steffi Naumann, Philipp Schmitz, Karl Worthmann   +3 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Unconscious errors enhance prefrontal-occipital oscillatory synchrony

Frontiers in Human Neuroscience, 2009
The medial prefrontal cortex (MFC) is critical for our ability to learn from previous mistakes. Here we provide evidence that neurophysiological oscillatory long-range synchrony is a mechanism of post-error adaptation that occurs even without conscious ...
Michael X Cohen, Michael X Cohen, Simon Van Gaal, Simon Van Gaal, K. Richard Ridderinkhof, Victor Lamme   +5 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

The role of anticipated emotions in self-control: linking self-control and the anticipatory ability to engage emotions associated with upcoming events

Frontiers in Psychology
Self-control is typically attributed to “cold” cognitive control mechanisms that top-down influence “hot” affective impulses or emotions. In this study we tested an alternative view, assuming that self-control also rests on the ability to anticipate ...
Johann D. Kruschwitz, Johann D. Kruschwitz, Thomas Goschke, Thomas Goschke, Elkhansa Ahmed Mohamed Ali, Anne-Carolin Kraehe, Anne-Carolin Kraehe, Franziska Maria Korb, Franziska Maria Korb, Henrik Walter, Henrik Walter   +10 more
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Default mode network connectivity contributes the augment effect stress recovery by natural viewing

Neurobiology of Stress
The psychological benefits of exposure to natural environments are well established. However, whether simply viewing nature images produce similar restorative effects and the brain mechanisms involved remain unclear.
Zini Chen, Chanyu Wang, Timothea Toulopoulou, Xiayan Chen, Lijing Niu, Haowei Dai, Qingzi Zhu, Yuanyuan Zeng, Ruibin Zhang   +8 more
doaj   +1 more source

Locomotor Sub-functions for Control of Assistive Wearable Robots

Frontiers in Neurorobotics, 2017
A primary goal of comparative biomechanics is to understand the fundamental physics of locomotion within an evolutionary context. Such an understanding of legged locomotion results in a transition from copying nature to borrowing strategies for ...
Maziar A. Sharbafi, Maziar A. Sharbafi, Andre Seyfarth, Guoping Zhao   +3 more
doaj   +1 more source