Results 61 to 70 of about 10,543,697 (281)

Early Diagnosis of Alzheimer's Disease by NIRF Spectroscopy\ud and Nuclear Medicine\ud [PDF]

, 2011
Novel approaches to Early Diagnosis of Alzheimer's Disease by NIRF Spectroscopy and Nuclear Medicine are presented and related cognitive, as well as molecular and cellular, models are critically evaluated ...
Baianu, Prof.Dr. I.C.
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

CSF dynamics as a predictor of cognitive progression

NeuroImage, 2021
Disproportionately enlarged subarachnoid-space hydrocephalus (DESH), characterized by tight high convexity CSF spaces, ventriculomegaly, and enlarged Sylvian fissures, is thought to be an indirect marker of a CSF dynamics disorder.
Petrice M. Cogswell, Stephen D. Weigand, Heather J. Wiste, Jeffrey L. Gunter, Jonathan Graff-Radford, David T. Jones, Christopher G. Schwarz, Matthew L. Senjem, David S. Knopman, Ronald C. Petersen, Clifford R. Jack, Jr   +10 more
doaj   +1 more source

Proposing a new focus for the study of natural and artificial cognitive systems [PDF]

, 2002
In the study of systems the function of the system is often a good hint to how it works. In the following paper I would like to suggest that in studying or modeling a cognitive system our pre-knowledge of their functions should be treated carefully.
Hershberg, Uri
core  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

The association of mood disorders and mild cognitive impairment with language performance in older adults: insights from a community healthcare setting

Frontiers in Dementia
BackgroundMood disorders are frequent in memory clinic populations, but their association with language difficulties in the context of cognitive decline is not well understood.
Nomiki Karpathiou, Nomiki Karpathiou, Angeliki Tsapanou, Angeliki Tsapanou, Areti Efthymiou, Evdoxia Kotsiou, Xanthi Arampatzi, Panagiota Zoi, Faidra Kalligerou, Paraskevi Sakka   +9 more
doaj   +1 more source

Enhancing Cognitive Diagnosis by Modeling Learner Cognitive Structure State

CoRR
Cognitive diagnosis represents a fundamental research area within intelligent education, with the objective of measuring the cognitive status of individuals. Theoretically, an individual's cognitive state is essentially equivalent to their cognitive structure state.
Zhifu Chen, Hengnian Gu, Jin Peng Zhou, Dongdai Zhou   +3 more
openaire   +3 more sources

A Cognitive Diagnosis Model for Identifying Coexisting Skills and Misconceptions [PDF]

Applied Psychological Measurement, 2017
At present, most existing cognitive diagnosis models (CDMs) are designed to either identify the presence and absence of skills or misconceptions, but not both. This article proposes a CDM that can be used to simultaneously identify what skills and misconceptions students possess.
Bor-Chen, Kuo, Chun-Hua, Chen, Jimmy, de la Torre   +2 more
openaire   +2 more sources

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Skill set profile clustering: the empty K-means algorithm with automatic specification of starting cluster centers [PDF]

, 2010
While students’ skill set profiles can be estimated with formal cognitive diagnosis models [8], their computational complexity makes simpler proxy skill estimates attractive [1, 4, 6].
Nugent, R., Ayers, E., Dean, N.
core   +4 more sources