Results 71 to 80 of about 16,732,514 (287)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Construction and diagnostic value of combined prediction model of cardiovascular indicators for risk of cognitive dysfunction in middle⁃aged and elderly population

open access: yesHuli yanjiu, 2022
ObjectiveTo construct a combined prediction model of cardiovascular indicators for the risk of cognitive dysfunction in middle⁃aged and elderly people,and to judge the diagnostic value of the prediction model,so as to better identify the risk of ...
LOU Fangli   +3 more
doaj  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Validation of a Questionnaire for Personality Profiling using Cognitive Diagnostic Modeling

open access: yesThe Spanish Journal of Psychology, 2018
Abstract This article describes the development of the ENCUIST (Extroversion, Neuroticism, Callous-Unemotional, Instability, Short-Test) questionnaire, which has been created to provide a personality profiling method based on a cognitive diagnostic modeling framework.
Javier Revuelta   +2 more
openaire   +3 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

A spreading-activation model of the semantic coordination of speech and gesture [PDF]

open access: yes, 2013
Kopp S, Bergmann K, Kahl S. A spreading-activation model of the semantic coordination of speech and gesture. In: Proceedings of the 35th Annual Meeting of the Cognitive Science Society (CogSci 2013). Austin, TX: Cognitive Science Society; 2013: 823-828.
Kopp, Stefan ; https://orcid.org/   +2 more
core  

Personalized recommendation algorithm for rehabilitation intervention in children with autism spectrum disorder based on the cognitive diagnosis model

open access: yesFrontiers in Psychology
AimThis study applied the Cognitive Diagnostic Model (CDM) to develop a personalized recommendation algorithm for rehabilitation intervention in children and adolescents with autism spectrum disorder (ASD).MethodsA total of 3,319 children and adolescents
Tian Shu   +5 more
doaj   +1 more source

Cognitive Diagnostic Modeling Using R

open access: yes, 2015
Cognitive diagnostic models (CDM) have been around for more than a decade but their application is far from widespread for mainly two reasons: (1) CDMs are novel, as compared to traditional IRT models. Consequently, many researchers lack familiarity with them and their properties, and (2) Software programs doing CDMs have been expensive and not readily
Ravand, Hamdollah, Robitzsch, Alexander
openaire   +2 more sources

On the Link between Cognitive Diagnostic Models and Knowledge Space Theory

open access: yesPsychometrika, 2015
The present work explores the connections between cognitive diagnostic models (CDM) and knowledge space theory (KST) and shows that these two quite distinct approaches overlap. It is proved that in fact the Multiple Strategy DINA (Deterministic Input Noisy AND-gate) model and the CBLIM, a competence-based extension of the basic local independence model
Heller, Jürgen   +3 more
openaire   +3 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

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