Results 61 to 70 of about 1,183,633 (304)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Preliminary evidence for developing safe and efficient fecal microbiota transplantation as potential treatment for aged related cognitive impairments

Frontiers in Cellular and Infection Microbiology, 2023
BackgroundRecent studies have reported that gut microbiota is closely associated with cognitive fuction. Fecal microbiota transplantation (FMT) may be a potential treatment for cognitive impairment, but its efficacy in patients with cognitive impairment ...
Xiaoxia Chen, Wanling Zhang, Zhijun Lin, Chunyan Zheng, Shufang Chen, Haihong Zhou, Zhou Liu   +6 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Comparison of the effectiveness of positivist psychotherapy and reality therapy on cognitive disturbance and relapse anxiety in addicts under treatment

Taḥqīqāt-i ̒Ulūm-i Raftārī, 2022
Aim and Background: Today, substance use disorders and their serious consequences are associated with many serious medical and psychiatric problems. In this regard, the present study was conducted to compare the effectiveness of positivist psychotherapy ...
Masoomeh Namjoo Aboosaeidi, Mahin Askari, Emad Yosefi   +2 more
doaj  

Cognition in schizophrenia and schizo-affective disorder: Impairments that are more similar than different [PDF]

, 2013
BACKGROUND: Cognition is increasingly being recognized as an important aspect of psychotic disorders and a key contributor to functional outcome. In the past, comparative studies have been performed in schizophrenia and schizo-affective disorder with ...
Barch, D. M, Carter, C. S, Gold, J. M, MacDonald, A. W, III, Owoso, A., Ragland, J. D, Silverstein, S. M, Strauss, M. E   +7 more
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Embelin Protects Against Acute Pentylenetetrazole-Induced Seizures and Positively Modulates Cognitive Function in Adult Zebrafish

Frontiers in Pharmacology, 2019
Purpose of the research: Epilepsy is a continuous process of neurodegeneration categorized by an enduring tendency to generate uncontrolled electrical firing known as seizures causing involuntary movement all over the body.
Uday Praful Kundap, Uday Praful Kundap, Brandon Kar Meng Choo, Yatinesh Kumari, Nafees Ahmed, Iekhsan Bin Othman, Mohd Farooq Shaikh   +6 more
doaj   +1 more source

Temporal association of psychotic and cognitive symptoms in an alcohol-induced psychosis case (eng)

Klinik Psikiyatri Dergisi, 2022
Alcohol use-related psychotic disorder is a complication of alcohol use disorder associated with heavy alcohol consumption for many years. It is usually seen after the age of 40 and is often accompanied by auditory hallucinations. Cognitive disorders are
Koray Yarız, Sivi Kuçi, Meltem Kamacı, Burcu Kahveci Öncü, Inci Ozgur Ilhan   +4 more
doaj   +1 more source

Psychopathology in Williams syndrome: the effect of individual differences across the lifespan [PDF]

, 2009
The present research aimed to comprehensively explore psychopathology in Williams syndrome (WS) across the lifespan and evaluate the relationship between psychopathology and age category (child or adult), gender and cognitive ability.
American Psychiatric Association, American Psychiatric Association, Helen F. Dodd, Jefferys D., Karmiloff-Smith A., Kaufman J., Melanie A. Porter, Mervis C. B., Pober B. R., Silverman W. K., Soni S., Switaj D. M., Woodcock R. W.   +12 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source