Results 71 to 80 of about 1,183,633 (304)

The Relationship between p-tau217, p-tau231, and p-tau205 in the Human Brain Is Affected by the Cellular Environment and Alzheimer’s Disease Pathology

Cells
The levels of p-tau217 and p-tau231 in cerebrospinal fluid (CSF) are associated with early amyloid beta (Aß) changes in the brain, while the CSF levels of p-tau205 are foremost related to tau pathology in the later stages of the disease.
Malin Wennström, Nina Schultz, Paula Mille Gallardo, The Netherlands Brain Bank, Geidy E. Serrano, Thomas G. Beach, Suchira Bose, Oskar Hansson   +7 more
doaj   +1 more source

Recent developments in Canine Cognitive Dysfunction Syndrome

Pet Behaviour Science, 2016
Canine Cognitive Dysfunction Syndrome (CCD) is a neurodegenerative disease affecting aging dogs. CCD is an underdiagnosed disease that involves at least 14% of geriatric dogs, but apparently less than 2% of diseased dogs are diagnosed.
Alejandro Seisdedos Benzal, Alba Galán Rodríguez   +1 more
doaj   +1 more source

Complete recovery from anxiety disorders following Cognitive Behavioural Therapy in children and adolescents: a meta analysis [PDF]

, 2017
Cognitive Behavior Therapy (CBT) is a well-established treatment for childhood anxiety disorders. Meta-analyses have concluded that approximately 60% of children recover following treatment, however these include studies using a broad range of diagnostic
Cooper, Peter, Creswell, Cathy, Murayama, Kou, Reardon, T., Reynolds, Shirley, Warwick, H., Wilson, C.   +6 more
core   +1 more source

Treating depressive disorders with the unified protocol: A preliminary randomized evaluation. [PDF]

, 2020
OBJECTIVES: This study aims to examine the efficacy of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP) for individuals diagnosed with a depressive disorder. METHOD: Participants included 44 adults who met criteria for major
Ametaj, Amantia A., Barlow, David H., Bentley, Kate H., Cardona, Nicole, Farchione, Todd J., Nauphal, Maya, Sauer-Zavala, Shannon, Steele, Stephanie Jarvi, Tirpak, Julianne Wilner, Wang, Mengxing   +9 more
core   +2 more sources

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Upregulated HCN currents and reduced intrinsic excitability in prefrontal cortical pyramidal neurons after maternal separation

Neurobiology of Disease
The prefrontal cortex (PFC) is a core region regulating emotion, is linked to pathological mood disorders, and is a target for antidepressant drugs. Neonatal maternal separation (MS) is an early-life chronic stressor leading to anxiety and depression in ...
Xing Wang, Fei Luo, Baoming Li
doaj   +1 more source

The Neurobiology of Eating Disorders. [PDF]

, 2019
Eating disorders are severe psychiatric illnesses with a typical age of onset in adolescence. Brain research in youth and young adults may help us identify specific neurobiology that contributes to onset and maintenance of those disorders.
DeGuzman, Marisa C, Frank, Guido KW, Shott, Megan E   +2 more
core  

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries. [PDF]

, 2020
This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease.
Adhikari, Bhim M, Agartz, Ingrid, Aghajani, Moji, Aleman, André, Althoff, Robert R, Altmann, Andre, Andreassen, Ole A, Baron, David A, Bartnik-Olson, Brenda L, Baskin-Sommers, Arielle R, Baune, Bernhard T, Bearden, Carrie E, Berner, Laura A, Bertolín, Sara, Boedhoe, Premika SW, Bralten, Janita, Bright, Joanna, Brouwer, Rachel M, Bruin, Willem B, Buitelaar, Jan K, Bülow, Robin, Caeyenberghs, Karen, Cecil, Charlotte AM, Chen, Jian, Ching, Christopher RK, Chye, Yann, Cohen, Ronald A, Cole, James H, Conrod, Patricia J, Dannlowski, Udo, De Brito, Stephane A, de Kovel, Carolien GF, de Zwarte, Sonja MC, Dennis, Emily L, Desrivieres, Sylvane, Dima, Danai, Donohoe, Gary, Ehrlich, Stefan, Esopenko, Carrie, Eyler, Lisa T, Fairchild, Graeme, Faraone, Stephen V, Favre, Pauline, Filippi, Courtney A, Fisher, Simon E, Fouche, Jean-Paul, Francks, Clyde, Frodl, Thomas, Garijo, Daniel, Gil, Yolanda, Grabe, Hans J, Grasby, Katrina L, Hajek, Tomas, Han, Laura KM, Hatton, Sean N, Hilbert, Kevin, Ho, Tiffany C, Holleran, Laurena, Homuth, Georg, Hosten, Norbert, Houenou, Josselin, Ivanov, Iliyan, Jahanshad, Neda, Jia, Tianye, Kelly, Sinead, Klein, Marieke, Kwon, Jun Soo, Laansma, Max A, Leerssen, Jeanne, Lueken, Ulrike, Marie Bas-Hoogendam, Janna, Neill, Joseph O', Nunes, Abraham, Opel, Nils, Piras, Fabrizio, Piras, Federica, Postema, Merel C, Pozzi, Elena, Salminen, Lauren E, Shatokhina, Natalia, Soriano-Mas, Carles, Spalletta, Gianfranco, Sun, Daqiang, Teumer, Alexander, Thomopoulos, Sophia I, Thompson, Paul M, Tilot, Amanda K, Tozzi, Leonardo, van der Merwe, Celia, Van Someren, Eus JW, van Wingen, Guido A, Völzke, Henry, Walton, Esther, Wang, Lei, Winkler, Anderson M, Wittfeld, Katharina, Wright, Margaret J, Yun, Je-Yeon, Zhang, Guohao, Zhang-James, Yanli   +99 more
core  

Predictors of employment in bipolar disorder : a systematic review [PDF]

, 2013
Background Severe work impairment can be present for a considerable proportion of the course of bipolar disorder (BD) and is costly for governments, services and individuals.
Bonnín, Burdick, Calabrese, Carlson, Clement, Coryell, Dean, Dickerson, Dickerson, Dunn, Eleanor Gilbert, Gilbert, Goldberg, Goodwin, Green, Hamilton, Hammen, Hirschfield, Huxley, Judd, Judd, Kaersten, Lerner, Levinson, Malhi, Martínez-Arán, Marwaha, Morselli, Murray, Patel, Reed, Robinson, Romans, Rosa, Rosa, Simon, Spearing, Steven Marwaha, Strauss, Stroup, Sánchez-Moreno, Tabarés-Seisdedos, Tohen, Tomás, Weschler, Wyatt, Wykes, Yan-Meier   +47 more
core   +1 more source