Results 221 to 230 of about 1,501,382 (305)

Hierarchical Summary Statistics Encoding Across Primary Visual and Posterior Parietal Cortices

Advanced Science, EarlyView.
This study shows that mouse V1 simultaneously encodes the ensemble mean and variance of motion, providing a robust summary‐statistic representation that persists despite single‐neuron variability. These signals propagate to PPC, where they are transformed into abstract category representations during decision making.
Young‐Beom Lee, Oliver James, Gaeun Jung, Doyun Lee, Yee‐Joon Kim   +4 more
wiley   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Music elicits different gene expression responses in the buccal cavity of age-related cognitive disorders patients and healthy controls. [PDF]

Front Aging Neurosci
Gómez-Carballa A, Navarro L, Mallah NEZ, Bello X, Pischedda S, Viz-Lasheras S, Currás MJ, Ferreirós-Vidal I, Mallah N, Montoto-Louzao J, Camino-Mera A, Castelo-Martínez L, Rey-Vázquez S, Redondo L, Dacosta-Urbieta A, Rivero-Calle I, Rodríguez-Tenreiro C, Martinón-Torres F, Salas A.   +18 more
europepmc   +1 more source

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

Socio-Emotional, Behavior and Cognitive Disorders Associated with Exposure to Trace Metals: A Cross-Sectional Pilot Study in School-Age Children in Haut-Katanga Province. [PDF]

Children (Basel)
Mbuyamba EB, Mande JN, Obadia PM, Lubaba Nkulu CB, Haufroid V, Nemery B, Mulumba CM, Wa Mukalay AM, Ris L, Lefebvre L, Luwa E-Andjafono DO.   +10 more
europepmc   +1 more source

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

Real world diagnostic performance of plasma p-tau217 for early-onset Alzheimer's disease in a cognitive disorders tertiary care setting. [PDF]

J Alzheimers Dis
Chatterjee P, Ivanic S, Southon A, McCarthy C, Patel SK, Christensen M, Darby D, Bush AI, Ayton S, Werden E, Brodtmann A.   +10 more
europepmc   +1 more source