Results 51 to 60 of about 1,931,867 (302)

Depressive and biopsychosocial frailty phenotypes:Impact on late-life cognitive disorders

open access: yes, 2023
In older age, frailty is a detrimental transitional status of the aging process featuring an increased susceptibility to stressors defined by a clinical reduction of homoeostatic reserves. Multidimensional frailty phenotypes have been associated with all-
Castellana, Fabio   +15 more
core   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Analysis of the Association Between Symptoms of Inattention and Hyperactivity–Impulsivity and Substance Abuse in University Students

open access: yesPsychiatry International
Background and objectives. Symptoms of Attention Deficit Hyperactivity Disorder (ADHD) are frequently present in university students, even without a clinical diagnosis, and may be aggravated by various factors.
Desirée Ibáñez-Tejedor, Omar Cauli
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Associations of handgrip strength asymmetry with physical frailty, cognitive impairment, and cognitive frailty: A cross-sectional finding from the Longitudinal Ageing Study in India (LASI), Wave 1 (2017-18)

open access: yesClinical Epidemiology and Global Health
Objectives: As one ages, it becomes essential to anticipate and address the obstacles that impede the pursuit of healthy ageing. Thus, the present study aims to find out the associations between hand grip strength (HGS) asymmetry, physical frailty ...
Inderdeep Kaur   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

The Association between Physical Frailty and Cognitive Performance in Older Adults Aged 60 to 96 Years: Data from the “Good Aging in Skåne” (GÅS) Swedish Population Study [PDF]

open access: yesAnnals of Geriatric Medicine and Research
Background The association between physical frailty and performance in different cognitive domains in the absence of cognitive disorders is poorly understood.
Katrina Lundberg   +3 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

open access: yesAging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi   +3 more
wiley   +1 more source

The association between social frailty, psychological resilience, and subsequent cognitive outcomes in older adults: A prospective cohort study

open access: yesThe Journal of Nutrition, Health and Aging
Background: The associations among social frailty, psychological resilience, and cognitive function, as well as their variations across sex and age, remain to be explored.
Yun-Jing Zhang, Cong Zhang, Qi-Yuan Lyu
doaj   +1 more source

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