Results 71 to 80 of about 4,911,548 (306)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Patterns of Cognitive Performance in Healthy Ageing in Northern Portugal [PDF]

, 2011
Background: The Minho Integrative Neuroscience Database (MIND)-Ageing project aims to identify predictors of healthy cognitive ageing, including socio-demographic factors.
Costa, Patrício Soares, Joseph Zihl, Cunha, P., Sousa, Nuno, Santos, Nadine Correia, Santos, N. C., Paulo, Ana Cristina, Ana Cristina Paulo, Joana Almeida Palha, Sampaio, Adriana, Patrı́cio Soares Costa, Nuno Sousa, Cerqueira, João, Patrício Soares Costa, Costa, P. S., João Cerqueira, Cerqueira, J., Pêgo, José M., Adriana Sampaio, Pedro Cunha, Sampaio, A., Palha, Joana Almeida, Sousa, N., Nadine Correia Santos, Cunha, Pedro, Paulo, A. C., Palha, J. A., Zihl, J., Zihl, Joseph   +28 more
core   +2 more sources

Beta power as a neural correlate of sensory features in autistic individuals

Journal of Neurodevelopmental Disorders
Background Autism spectrum disorder (ASD) is characterized by social communication difficulties, restricted and repetitive behaviors, and sensory atypicalities.
Julie Chaudet, Julien Pichot, Amandine Pedoux, Mathis Fleury, Anna Maruani, Valérie Vantalon, Elise Humeau, Thomas Bourgeron, Josselin Houenou, Guillaume Dumas, Edouard Duchesnay, Richard Delorme, Anton Iftimovici, Aline Lefebvre   +13 more
doaj   +1 more source

Cognitive function in COPD [PDF]

European Respiratory Journal, 2010
In order to characterise the overall clinical picture of chronic obstructive pulmonary disease (COPD) a better understanding of all relevant comorbidities is required. It is increasingly recognised that COPD is a multi-component disease, but little attention has been paid to its effects on cognitive function.Cognitive dysfunction is associated with ...
Dodd, J W, Getov, S V, Jones, P W
openaire   +3 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

The effect of one-night sleep deprivation on cognitive functions in healthy young adults

, 2021
Introduction: The effects of acute sleep deprivation on cognitive function have not been clearly elucidated. The purpose of this study was to evaluate changes in cognitive function in healthy adults after one night of sleep deprivation. Material
Ozturk, Levent, Gülnur Öztürk, Buse Çetin, Levent Öztürk, Cetin, Buse, Pekcetin, Serkan, Ozturk, Gulnur, Serkan Pekçetin   +7 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

How cognitive reserve affects neuropsychological functions

, 2023
Cognitive reserve (CR) is defined as the ability to flexibly use available brain resources when brain changes due to aging or damages occur. The adaptability of cognitive processes allows the individual to preserve daily functioning and is associated ...
Giulia Marselli, Maria Casagrande, Angela Guarino, Ilaria Corbo, Giovanna Troisi   +4 more
core  

Biochemical Parameters in Cognitive Functions

Neuropsychiatric Disease and Treatment, 2020
Alicja Katarzyna Popiołek,1,2 Aleksandra Chyrek-Tomaszewska,1,2 Agnieszka Stachowicz-Karpińska,1,2 Maciej Kazimierz Bieliński,1,2 Alina Borkowska1 1Department of Clinical Neuropsychology, Nicolaus Copernicus University in Toruń, Collegium Medicum in ...
Popiolek AK, Chyrek-Tomaszewska A, Stachowicz-Karpińska A, Bieliński MK, Borkowska A   +4 more
doaj  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source