Results 71 to 80 of about 1,611,560 (307)

Cognitive dysfunction improves in systemic lupus erythematosus: Results of a 10 years prospective study [PDF]

, 2018
Objective Cognitive impairment (CI) has been described in 3–80% of Systemic lupus erythematosus (SLE) patients but only short-term studies evaluated its over-time changes, suggesting that CI is usually a stable finding. We aimed at evaluating the changes
Alessandri, Cristiano, Ceccarelli, Fulvia, Conti, Fabrizio, Marianetti, Massimo, Massaro, Laura, Mina, Concetta, Perricone, Carlo, Pirone, Carmelo, Spinelli, Francesca Romana, Valesini, Guido   +9 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Cognitive Deficiency in Cannabis Consumers

Buletin Psikologi, 2021
While being the most abused psychoactive substance (PS), cannabis is also the least researched PS (especially) in Indonesia. Since 24% of total PS abusers within the last year is students, we could only form an a priori on what cannabis consumption might
Wurgan Rahadian, Abraham Sabda Respati, Supra Wimbarti, Sri Koesrohmaniah   +3 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Towards a shared ontology: a generic classification of cognitive processes in conceptual design [PDF]

, 2017
Towards addressing ontological issues in design cognition research, this paper presents the first generic classification of cognitive processes investigated in protocol studies on conceptual design cognition.
*Akin, *Akin, *Ball, *Bilda, *Bilda, *Bilda, *Chan, *Chen, *Chiu, *Daly, *Goel, *Jin, *Jin, *Kim, *Kim, *Kim, *Kim, *Kim, *Lane, *Lee, *Lloyd, *Maher, *Maher, *McNeill, *Park, *Sun, *Suwa, *Suwa, *Suwa, *Suwa, *Won, *Yu, *Yu, *Yu, *Yu, Abraham, Boyle, Bruce, Buys, Ericsson, Eysenck, Federmeier, Finke, Gero, Gero, Gero, Gobet, Kosslyn, Lloyd, Maher, McKoy, Newell, Rabbitt, Runco, Sim, Sim, Squire, Tulving, Tversky, van Someren   +59 more
core   +2 more sources

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Cortical processing of electrocutaneous stimuli in chronic stroke patients: a relationship with post-stroke shoulder pain. [PDF]

, 2010
Cerebral stroke is often associated with changes in cognitive-evaluative and somatosensory functions which may play a role in the development and maintenance of post-stroke ...
Buitenweg, J.R., Dongen, R.T.M. van, Geurts, A.C.H., IJzerman, M.J., Renzenbrink, G.J., Roosink, M.   +5 more
core   +1 more source

Cognitive function and hypertension [PDF]

Journal of Human Hypertension, 2008
The importance of lowering blood pressure (BP) in hypertensive subjects is well known but the relationship between hypertension and cognitive function is controversial. This article reviews the role of hypertension in the aetiology of cognitive impairment and the relationships between BP, cerebral perfusion and cognition. It also summarizes findings of
Birns, J., Kalra, L.
openaire   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source