Results 111 to 120 of about 641,525 (312)

Occurrence, Risk Factors, and Prognosis of Acute Cerebral Microinfarcts in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic cerebral small vessel disease in adults. This study investigates the occurrence, risk factors, and prognosis of acute cerebral microinfarcts (ACMIs) in patients with CADASIL.
Xuejiao Men, Hui Li, Zhuoxin Guo, Bin Qin, Hengfang Ruan, Ruipeng Cai, Bingjun Zhang, Aimin Wu, Lei Wei, Yongqiang Dai, Haiyan Li, Zhengqi Lu   +11 more
wiley   +1 more source

Gait and cognition: mapping the global and discrete relationships in ageing and neurodegenerative disease [PDF]

, 2016
Recent research highlights the association of gait and cognition in older adults but a stronger understanding is needed to discern coincident pathophysiology, patterns of change, examine underlying mechanisms and aid diagnosis.
Bunce, Jennifer, Burn, David, Lord, Sue, Morris, Rosie, Rochester, Lynn   +4 more
core   +2 more sources

Threshold Values of Sleep Spindles Features in Healthy Adults Using Scalp‐EEG and Associations With Sleep Parameters

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Sleep spindles are an electrophysiological fingerprint of the sleeping human brain. They can be described in terms of duration, frequency, amplitude, and density, and vary widely according to age and sex. Spindles play a role in sleep and wake functions and are altered in several neurological and psychiatric disorders.
Julien Coelho, Heloïse Degros, Jean‐Arthur Micoulaud‐Franchi, Patricia Sagaspe, Emmanuel d'Incau, Paul Galvez, Christian Berthomier, Pierre Philip, Jacques Taillard   +8 more
wiley   +1 more source

Efficacy of Cognitive Training in Older Adults with and without Subjective Cognitive Decline Is Associated with Inhibition Efficiency and Working Memory Span, Not with Cognitive Reserve

Frontiers in Aging Neuroscience, 2018
The present study explores the role of cognitive reserve, executive functions, and working memory (WM) span, as factors that might explain training outcomes in cognitive status.
Ramón López-Higes, María T. Martín-Aragoneses, María T. Martín-Aragoneses, Susana Rubio-Valdehita, María L. Delgado-Losada, Pedro Montejo, Mercedes Montenegro, José M. Prados, Jaisalmer de Frutos-Lucas, David López-Sanz   +9 more
doaj   +1 more source

Mild cognitive impairment [PDF]

, 2014
Mild Cognitive Impairment (MCI) is a disease between normal cognitive ageing and dementia. In recent years the term MCI has been recognized as a pre-dementia state, raising an important subject for investigation in the prevention of dementia.
Góngora Rivera, Fernando, Isordia Martínez, Javier, Leal Bailey, H., Ortiz Jiménez, Xóchitl A.   +3 more
core   +1 more source

A 14‐Year Study of Serum Glial Fibrillary Acidic Protein and Total Tau in Premanifest Huntington's

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT There is a pressing need for blood biomarkers that can identify Huntington's disease (HD) gene carriers' proximity to manifest disease. We previously examined serial serum neurofilament light (NfL) concentrations in 21 premanifest HD gene carriers and 14 controls over 14 years, finding that NfL demonstrates high prognostic value and distinct ...
Natalia E. Owen, Zanna J. Voysey, Jonathan A. Holbrook, Maura Malpetti, Clara Le Draoulec, Lennart R. B. Spindler, Anna O. G. Goodman, Alpar S. Lazar, Roger A. Barker   +8 more
wiley   +1 more source

Gait and Balance in Alzheimer\u27s Disease: A Retrospective Analysis Across Varying Levels of Cognitive Impairment

, 2017
Background: It was once thought that Alzheimer’s disease (AD) affected mostly cognition with minor motor impairment; however, it is becoming apparent that motor impairment may also be a prominent feature.
Contreras, Diana, Heim, Jessica, Nelson, Jun   +2 more
core  

KIF5A p.Pro986Leu Risk Variant and Accelerated Progression of Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study explored the impact of KIF5A rs113247976 (p.Pro986Leu), a risk allele for amyotrophic lateral sclerosis (ALS), on phenotypic variability in two Italian ALS cohorts (discovery, n = 865; replication, n = 1174). The minor allele (T) frequency was 0.015.
Arianna Manini, Rosario Vasta, Alberto Brusati, Francesco Scheveger, Silvia Peverelli, Alessio Maranzano, Alberto Doretti, Francesco Gentile, Eleonora Colombo, Maura Brunetti, Cristina Moglia, Antonio Canosa, Umberto Manera, Maurizio Grassano, Davide Gentilini, Stefano Messina, Federico Verde, Claudia Morelli, John E. Landers, Bryan J. Traynor, Adriano Chiò, Vincenzo Silani, Andrea Calvo, Antonia Ratti, Nicola Ticozzi   +24 more
wiley   +1 more source

Cognitive impairment six months after ischaemic stroke: a profile from the ASPIRE-S study. [PDF]

, 2015
Background Cognitive impairment commonly occurs in the acute phase post-stroke, but may persist with over half of all stroke survivors experiencing some form of long-term cognitive deficit.
ASPIRE-S study group, Brewer, Linda, Hall, Patricia, Hickey, Anne, Horgan, Frances, Mellon, Lisa, Williams, David   +6 more
core   +1 more source

CNS Mitochondria‐Derived Vesicle in Blood: Potential Biomarkers for Brain Mitochondria Dysfunction

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial dysfunction is a hallmark of neurodegenerative diseases like Alzheimer's (AD) and Parkinson's (PD). Our goal was to develop practical, noninvasive methods to assess mitochondrial status through the detection of mitochondria‐derived vesicles (MDVs).
Qi Liu, Wentao Chen, Yahong Wu, Zhen Guo, Jun Chen, Chen Tian, Pan Wang, Shaopeng Zeng, Bin Xu, Jing Duan, Shilong Han, Xiao Xiong, Jing Zhang   +12 more
wiley   +1 more source