Results 131 to 140 of about 4,454,503 (388)

Obstructive sleep apnea severity affects amyloid burden in cognitively normal elderly a longitudinal study [PDF]

open access: yes, 2018
Recent evidence suggests that Obstructive Sleep Apnea (OSA) may be a risk factor for developing Mild Cognitive Impairment and Alzheimer’s disease.
Bubu, Omonigho M.   +3 more
core   +2 more sources

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung   +7 more
wiley   +1 more source

A Minimally Invasive Framework Reveals Region‐Specific Cerebrovascular Remodeling in Aging Using Intravital Functional Ultrasound Imaging and Ultrasound Localization Microscopy (fUS‐ULM)

open access: yesAdvanced Science
Aging impairs cerebrovascular structure and function, contributing to cognitive decline and dementia. Here, a novel, high‐resolution, intravital imaging platform is presented that combines functional ultrasound (fUS) and ultrasound localization ...
Sharon Negri   +16 more
doaj   +1 more source

Determinants of post-stroke cognitive impairment: analysis from VISTA [PDF]

open access: yes, 2017
BACKGROUND: Post-stroke cognitive impairment (PSCI) occurs commonly and is linked with development of dementia. We investigated the relationship between demographic, clinical and stroke symptoms at stroke onset and the presence of PSCI at 1 and 3 ...
Ali   +17 more
core   +2 more sources

Cognitive Impairment in CKD: Pathophysiology, Management, and Prevention.

open access: yesAmerican Journal of Kidney Diseases, 2019
Patients with chronic kidney disease (CKD) are at substantially higher risk for developing cognitive impairment compared with the general population, and both lower glomerular filtration rate and the presence of albuminuria are associated with the ...
David A. Drew, D. Weiner, M. Sarnak
semanticscholar   +1 more source

Cutaneous Phosphorylated Alpha‐Synuclein in Lewy Body Dementia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the test performance of cutaneous phosphorylated alpha‐synuclein (P‐SYN) in dementia with Lewy bodies (DLB), individuals with reduced Montreal Cognitive Assessment (MoCA) and healthy controls. Methods This is the first subgroup analysis of the Synuclein‐One study, a prospective, blinded study evaluating P‐SYN detection ...
Christopher H. Gibbons   +31 more
wiley   +1 more source

Phospholipase D, a Novel Therapeutic Target Contributes to the Pathogenesis of Neurodegenerative and Neuroimmune Diseases

open access: yesAnalytical Cellular Pathology
Phospholipase D (PLD) is an enzyme that consists of six isoforms (PLD1–PLD6) and has been discovered in different organisms including bacteria, viruses, plants, and mammals.
Weiwei Zhang   +3 more
doaj   +1 more source

Associations of apolipoprotein E ε4 allele, regional cerebral blood flow, and serum liver function markers in patients with cognitive impairment

open access: yesFrontiers in Neurology
IntroductionThe ε4 allele of the apolipoprotein E gene (APOE4) is expressed abundantly in both the brain and peripheral circulation as a genetic risk factor for Alzheimer’s disease (AD). Cerebral blood flow (CBF) dysfunction is an essential feature of AD,
Hao Wang   +10 more
doaj   +1 more source

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