Results 121 to 130 of about 641,525 (312)

Phospholipase D, a Novel Therapeutic Target Contributes to the Pathogenesis of Neurodegenerative and Neuroimmune Diseases

Analytical Cellular Pathology
Phospholipase D (PLD) is an enzyme that consists of six isoforms (PLD1–PLD6) and has been discovered in different organisms including bacteria, viruses, plants, and mammals.
Weiwei Zhang, Feiqi Zhu, Jie Zhu, Kangding Liu   +3 more
doaj   +1 more source

Associations of apolipoprotein E ε4 allele, regional cerebral blood flow, and serum liver function markers in patients with cognitive impairment

Frontiers in Neurology
IntroductionThe ε4 allele of the apolipoprotein E gene (APOE4) is expressed abundantly in both the brain and peripheral circulation as a genetic risk factor for Alzheimer’s disease (AD). Cerebral blood flow (CBF) dysfunction is an essential feature of AD,
Hao Wang, Lin Shi, Shimei Luo, Yishan Luo, Chunyan Xu, Guozhen Qiu, Qiwen Guo, Chunchun Chen, Taikun Lu, Kangding Liu, Feiqi Zhu   +10 more
doaj   +1 more source

Macrophages come to mind as keys to cognitive decline [PDF]

, 2016
Cognitive impairment, an underappreciated consequence of hypertension, is linked to cerebral arteriolar disease through poorly defined mechanisms. A study by Faraco et al.
D.G. Harrison, Davies, Faraco, Launer, Liu, Tomasz J. Guzik   +5 more
core   +1 more source

Hypertension and cognitive impairment [PDF]

Annals of Translational Medicine, 2017
Numerous studies have demonstrated that hypertension increases the risk for cognitive impairment, vascular dementia, and Alzheimer’s disease (1-11). In a 5-year longitudinal study of 353 community-dwelling persons, mean age 72 years, increased blood pressure variability was associated with poorer cognitive function (5). In a study of 1,373 persons aged
openaire   +3 more sources

Histone Deacetylase 6 Brain PET in Amyotrophic Lateral Sclerosis‐Frontotemporal Spectrum Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective [18F]EKZ‐001 is a positron emission tomography (PET) tracer targeting histone deacetylase 6 (HDAC6), an enzyme responsible for intracellular transport and clearance of misfolded proteins. HDAC6 modulation is a promising treatment strategy in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS).
Greet Vanderlinden, Charles Carron, Donatienne Van Weehaeghe, Joke De Vocht, Fouke Ombelet, Pegah Masrori, Caro De Weerdt, Rebecca E. James, Lauren T. Evans, Frederick A. Schroeder, Jacob M. Hooker, Michel Koole, Janice E. Kranz, Tonya M. Gilbert, Philip Van Damme, Koen Van Laere   +15 more
wiley   +1 more source

Single-channel EEG features during n-back task correlate with working memory load [PDF]

arXiv, 2020
Working Memory (WM) load is an important cognitive feature that is highly correlated with mental effort. Several neurological biomarkers such as theta power and mid-frontal activity show increased activity with increasing WM load. Such correlations often break down in cognitively impaired individuals, making WM load biomarkers a valuable tool for the ...
arxiv  

Nuclei‐Specific Amygdala Enlargement Is Linked to Psychiatric Comorbidities in Drug‐Resistant Focal Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amygdala enlargement has been the subject of controversial studies regarding its significance in terms of pathogenicity both in epilepsy and in psychiatric comorbidities such as anxiety, depression, and post‐traumatic stress disorder.
Hélène Mourre, Julia Makhalova, Lisa Soncin, Elodie Garnier, Hugo Dary, Arnaud Le Troter, Roy A. M. Haast, Benoit Testud, Marie Arthuis, Samuel Medina Villalon, Stanislas Lagarde, Francesca Pizzo, Christian Bénar, Jean‐Philippe Ranjeva, Maxime Guye, Fabrice Bartolomei   +15 more
wiley   +1 more source

Tau and atrophy: domain-specific relationships with cognition. [PDF]

, 2019
BackgroundLate-onset Alzheimer's disease (AD) is characterized by primary memory impairment, which then progresses towards severe deficits across cognitive domains.
Alzheimer’s Disease Neuroimaging Initiative, Banks, Sarah J, Brewer, James B, Dale, Anders M, Digma, Leonardino A, Madsen, John R, Reas, Emilie T   +6 more
core  

Spoken Language Biomarkers for Detecting Cognitive Impairment

, 2017
In this study we developed an automated system that evaluates speech and language features from audio recordings of neuropsychological examinations of 92 subjects in the Framingham Heart Study.
Alhanai, Tuka, Au, Rhoda, Glass, James
core   +1 more source

The assessment of pain in older people [PDF]

, 2007
Pain is under-recognised and under-treated in older people. It is a subjective, personal experience, only known to the person who suffers. The assessment of pain is particularly challenging in the presence of severe cognitive impairment, communication ...
Closs, S.J., Collett, B., O'Mahoney, S., Potter, J., Schofield, Pat   +4 more
core   +1 more source