Results 51 to 60 of about 3,361,255 (339)

Secondary prevention in cognitive frailty: the Treviso Dementia Registry

Geriatric Care, 2016
Dementia is one of the most disabling health conditions for older people. Increasing attention is paid to the preclinical phase such as cognitive frailty and mild cognitive impairment, and to the prevention programs designed to reduce the number of ...
Maurizio Gallucci
doaj   +1 more source

Protein kinase FAM20C—when subcellular localization matters

FEBS Letters, EarlyView.
FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
wiley   +1 more source

Predictive factors and risk and protection groups for loneliness in older adults: a population-based study

BMC Psychology
Background Loneliness is considered a public health problem, particularly among older adults. Although risk factors for loneliness have been studied extensively, fewer studies have focused on the protected and risk groups that these factors configure ...
Pedro Montejo Carrasco, David Prada Crespo, Ana Isabel Reinoso García, Monserrat Lozano Ibáñez, Borja Montejo Rubio, Mercedes Montenegro-Peña   +5 more
doaj   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Genetic Predictors of Change in Episodic Verbal Memory by Cognitive Intervention: ACT, PICALM, BDNF, NRG1, APOE Genes and Their Interactions in Situations of Cognitive Demand

Journal of Integrative Neuroscience, 2022
Background: Cognitive interventions (CIs) in the elderly are activities that seek to improve cognitive performance and delay its deterioration. Our objectives were to study potential genetic predictors of how a CI program may influence immediate and ...
Pedro Montejo Carrasco, David Prada Crespo, María Luisa Delgado Losada, Christian Montejo Rubio, Mercedes Montenegro-Peña   +4 more
doaj   +1 more source

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, EarlyView.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source

Event-Related Potentials in Relation to Risk-Taking: A Systematic Review

Frontiers in Behavioral Neuroscience, 2018
Event-related potentials (ERPs) have been used to investigate neural mechanisms underlying risk-related decisions over the last 16 years. We aimed to systematically evaluate associations between risk-taking and ERP components elicited during decisions ...
Dilushi Chandrakumar, Daniel Feuerriegel, Daniel Feuerriegel, Stefan Bode, Megan Grech, Hannah A. D. Keage   +5 more
doaj   +1 more source

A RE-AIM Analysis of an Intergenerational Dementia Education Program

Frontiers in Public Health, 2020
Objectives: Children often have a lack of dementia understanding and poor attitudes toward people with dementia. Intergenerational programs are increasingly common, but the effects on knowledge and attitudes related to dementia are mixed, especially in ...
Ashleigh E. Smith, Ashleigh E. Smith, Georgina L. Kamm, Samantha Lai, Melissa J. Hull, Melissa J. Hull, Jess R. Baker, Rachel Milte, Julie Ratcliffe, Tobias Loetscher, Hannah A. D. Keage   +10 more
doaj   +1 more source

Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice

Scientific Reports, 2019
In this study, we investigated lipopolysaccharide (LPS)-induced cognitive impairment and neuroinflammation in C57BL/6J mice by using behavioral tests, immunofluorescence, enzyme-linked immunosorbent assay (ELISA) and Western blot.
Jiayi Zhao, Wei Bi, Shu Xiao, Xin Lan, Xiaofeng Cheng, Jiawei Zhang, Daxiang Lu, Wei Wei, Yanping Wang, Hong-mei Li, Yongmei Fu, Lihong Zhu   +11 more
semanticscholar   +1 more source

Report on the 2nd MObility for Vesicle research in Europe (MOVE) symposium—2024

FEBS Open Bio, EarlyView.
The 2nd MObility for Vesicle research in Europe (MOVE) Symposium in Belgrade brought over 280 attendees from 28 countries to advance extracellular vesicle (EV) research. Featuring keynotes, presentations, and industry sessions, it covered EV biogenesis, biomarkers, therapies, and manufacturing.
Dorival Mendes Rodrigues‐Junior, Michaela Kocholata, Marilena E. Lekka, Olga Janouskova, Moran Yadid, Maja Kosanovic   +5 more
wiley   +1 more source