Results 41 to 50 of about 2,743,206 (258)

Different patterns of white matter degeneration using multiple diffusion indices and volumetric data in mild cognitive impairment and Alzheimer patients [PDF]

, 2012
Alzheimeŕs disease (AD) represents the most prevalent neurodegenerative disorder that causes cognitive decline in old age. In its early stages, AD is associated with microstructural abnormalities in white matter (WM).
Alves, Gilberto Sousa, Gilberto Sousa Alves, Felipe Sudo, Tarik Karakaya, Letice Valente, Laurence O’Dwyer, Viola Oertel-Knöchel, Engelhardt, Eliasz, David Prvulovic, Denise Moreira, Christian Knöchel, O’Dwyer, Laurence, Karakaya, Tarik, Fabian Fuβer, Carlos Eduardo Alves, Fußer, Fabian, Johannes Pantel, Laurence O'Dwyer, Valente, Letice, Jerson Laks, Prvulovic, David, Moreira, Denise, Alves, Carlos Eduardo, Alina Jurcoane, Pantel, Johannes, Oertel-Knöchel, Viola, Laks, Jerson, Eliasz Engelhardt, Sudo, Felipe, Fabian Fußer, Jurcoane, Alina, Knöchel, Christian   +31 more
core   +2 more sources

Predictive factors and risk and protection groups for loneliness in older adults: a population-based study

BMC Psychology
Background Loneliness is considered a public health problem, particularly among older adults. Although risk factors for loneliness have been studied extensively, fewer studies have focused on the protected and risk groups that these factors configure ...
Pedro Montejo Carrasco, David Prada Crespo, Ana Isabel Reinoso García, Monserrat Lozano Ibáñez, Borja Montejo Rubio, Mercedes Montenegro-Peña   +5 more
doaj   +1 more source

OLINK proteomics identifies inflammatory protein signatures associated with vascular cognitive impairment in diabetes

Frontiers in Immunology
IntroductionVascular cognitive impairment (VCI) is a syndrome of cognitive dysfunction attributable to vascular risk factors and cerebrovascular diseases, representing a major component of global dementia burden.
Yuying Wang, Yuying Wang, Zhenyu Zhao, Zhenyu Zhao, Linna Ji, Linna Ji, Haoying He, Haoying He, Sisi Peng, Sisi Peng, Juan Xu, Juan Xu, Zhipeng Xu, Zhipeng Xu, Junjian Zhang, Junjian Zhang   +15 more
doaj   +1 more source

Secondary prevention in cognitive frailty: the Treviso Dementia Registry

Geriatric Care, 2016
Dementia is one of the most disabling health conditions for older people. Increasing attention is paid to the preclinical phase such as cognitive frailty and mild cognitive impairment, and to the prevention programs designed to reduce the number of ...
Maurizio Gallucci
doaj   +1 more source

Sleep Time Estimated by an Actigraphy Watch Correlates With CSF Tau in Cognitively Unimpaired Elders: The Modulatory Role of APOE

Frontiers in Aging Neuroscience, 2021
There is increasing evidence of the relationship between sleep and neurodegeneration, but this knowledge is not incorporated into clinical practice yet.
Sara López-García, Carmen Lage, Ana Pozueta, María García-Martínez, Martha Kazimierczak, Andrea Fernández-Rodríguez, María Bravo, Luis Reyes-González, Juan Irure, Marcos López-Hoyos, Eloy Rodríguez-Rodríguez, Pascual Sánchez-Juan   +11 more
doaj   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Structural network efficiency is associated with cognitive impairment in small-vessel disease. [PDF]

, 2014
To characterize brain network connectivity impairment in cerebral small-vessel disease (SVD) and its relationship with MRI disease markers and cognitive impairment.METHODS: A cross-sectional design applied graph-based efficiency analysis to deterministic
Lawrence, AJ, A. W. Chung, T. R. Barrick, Chung, AW, Barrick, Thomas R., Lawrence, Andrew J.; id_orcid, A. J. Lawrence, H. S. Markus, Morris, RG, Morris, Robin G., Barrick, TR, Chung, Ai Wern, R. G. Morris, Markus, Hugh S., Markus, HS   +14 more
core   +1 more source

The role of thyroid hormones in Alzheimer's disease: Associations with cerebrospinal fluid biomarkers and diagnostic performance

Journal of Alzheimer's Disease Reports
Background The relationship between serum thyroid function indicators and cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) pathology, as well as their diagnostic value in dementia differentiation, remains poorly understood in individuals ...
Yazhen Huang, Meina Quan, Qianqian Wang, Junhua Liang, Tingting Li, Wei Wang   +5 more
doaj   +1 more source

Endocan: A Key Player of Cardiovascular Disease

Frontiers in Cardiovascular Medicine, 2022
Endothelial dysfunction is considered to be an early change in atherosclerosis. Endocan, also known as endothelial cell specific molecule-1, is a soluble proteoglycan mainly secreted by endothelial cells.
Jinzhi Chen, Liping Jiang, Liping Jiang, Xiao-Hua Yu, Mi Hu, Yang-Kai Zhang, Xin Liu, Pingping He, Xinping Ouyang   +8 more
doaj   +1 more source