Results 51 to 60 of about 3,013,970 (265)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Different patterns of white matter degeneration using multiple diffusion indices and volumetric data in mild cognitive impairment and Alzheimer patients [PDF]

, 2012
Alzheimeŕs disease (AD) represents the most prevalent neurodegenerative disorder that causes cognitive decline in old age. In its early stages, AD is associated with microstructural abnormalities in white matter (WM).
Alves, Gilberto Sousa, Gilberto Sousa Alves, Felipe Sudo, Tarik Karakaya, Letice Valente, Laurence O’Dwyer, Viola Oertel-Knöchel, Engelhardt, Eliasz, David Prvulovic, Denise Moreira, Christian Knöchel, O’Dwyer, Laurence, Karakaya, Tarik, Fabian Fuβer, Carlos Eduardo Alves, Fußer, Fabian, Johannes Pantel, Laurence O'Dwyer, Valente, Letice, Jerson Laks, Prvulovic, David, Moreira, Denise, Alves, Carlos Eduardo, Alina Jurcoane, Pantel, Johannes, Oertel-Knöchel, Viola, Laks, Jerson, Eliasz Engelhardt, Sudo, Felipe, Fabian Fußer, Jurcoane, Alina, Knöchel, Christian, Alves Gilberto Sousa, Alves Carlos Eduardo, Prvulovic David, Sudo Felipe, Karakaya Tarik, Fuβer Fabian, Oertel-Knöchel Viola, O’Dwyer Laurence, Valente Letice, Moreira Denise, Knöchel Christian, Laks Jerson, Pantel Johannes, Engelhardt Eliasz, Jurcoane Alina   +46 more
core   +2 more sources

A cross‐sectional study exploring cognitive impairment in kidney failure

, 2021
Background: Little is known of the prevalence or associated factors of cognitive impairment in people with kidney failure. Assessment of cognition is necessary to inform comprehension of healthcare information, aptitude for dialysis modality and informed
Theresa Green, Nicholas, P, Louise Purtell, Green, T, Pauline Nicholas, Purtell, L, Ann Bonner, Bonner, A   +7 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Late life depression with cognitive impairment: Evaluation and treatment

, 2008
Consuelo H Wilkins1,2, Jose Mathews2, Yvette I Sheline21Department of Medicine (Division of Geriatrics and Nutritional Science); 2Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USAAbstract: Older adults with depression
Yvette I Sheline, Consuelo H Wilkins, Jose Mathews, Consuelo Wilkins   +3 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Melatonin for cognitive impairment (Protocol) [PDF]

, 2005
This is the protocol for a review and there is no abstract. The objectives are as follows: The primary objective is a systematic review of evidence relating to the clinical efficacy and safety of melatonin in the treatment of manifestations of dementia ...
Duncan, V., Morgan, D.G., Jansen, S.L., Forbes, D.   +3 more
core   +1 more source

Event-Related Potentials in Relation to Risk-Taking: A Systematic Review

Frontiers in Behavioral Neuroscience, 2018
Event-related potentials (ERPs) have been used to investigate neural mechanisms underlying risk-related decisions over the last 16 years. We aimed to systematically evaluate associations between risk-taking and ERP components elicited during decisions ...
Dilushi Chandrakumar, Daniel Feuerriegel, Daniel Feuerriegel, Stefan Bode, Megan Grech, Hannah A. D. Keage   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Evaluation of cognitive assessment and cognitive intervention for people with multiple sclerosis [PDF]

, 2002
Objectives: Cognitive problems in multiple sclerosis are common but any possible benefits of treatment remain uncertain. The aim of the study was to evaluate the benefits of providing a psychology service, including cognitive assessment and intervention,
Weyman, N., Blumhardt, L. D., Blumhardt, L.D., Harding, J., Lincoln, N. B., Dent, A., Nicholl, C., Lincoln, N.B., Playford, E.D., Playford, E. Diane   +9 more
core   +1 more source