Results 71 to 80 of about 4,454,503 (388)

Permutation entropy and irreversibility in gait kinematic time series from patients with mild cognitive decline and early alzheimer’s dementia [PDF]

, 2019
Gait is a basic cognitive purposeful action that has been shown to be altered in late stages of neurodegenerative dementias. Nevertheless, alterations are less clear in mild forms of dementia, and the potential use of gait analysis as a biomarker of ...
Algarra Lucas, María del Carmen, Chicalna Actis, Guadalupe, Fernández Travieso, Jorge, Gómez Andrés, David, Martin Gonzalo, Juan Andrés, Miralles Martínez, Ambrosio A., Palmí Cartés, Itziar, Pulido Valdeolivas, Irene, Rausell, Estrella, Torrecillas Narváez, María Dolores, Wang, Ting, Wang, Yu, Zanin, Massimiliano   +12 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Macrophages come to mind as keys to cognitive decline [PDF]

, 2016
Cognitive impairment, an underappreciated consequence of hypertension, is linked to cerebral arteriolar disease through poorly defined mechanisms. A study by Faraco et al.
D.G. Harrison, Davies, Faraco, Launer, Liu, Tomasz J. Guzik   +5 more
core   +1 more source

Association of Blood Pressure Lowering With Incident Dementia or Cognitive Impairment: A Systematic Review and Meta-analysis.

Journal of the American Medical Association (JAMA), 2020
Importance The benefit of blood pressure lowering for the prevention of dementia or cognitive impairment is unclear. Objective To determine the association of blood pressure lowering with dementia or cognitive impairment.
Diarmaid Hughes, C. Judge, R. Murphy, Elaine A. Loughlin, M. Costello, W. Whiteley, J. Bosch, M. O’Donnell, M. Canavan   +8 more
semanticscholar   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Genetic Predictors of Change in Episodic Verbal Memory by Cognitive Intervention: ACT, PICALM, BDNF, NRG1, APOE Genes and Their Interactions in Situations of Cognitive Demand

Journal of Integrative Neuroscience, 2022
Background: Cognitive interventions (CIs) in the elderly are activities that seek to improve cognitive performance and delay its deterioration. Our objectives were to study potential genetic predictors of how a CI program may influence immediate and ...
Pedro Montejo Carrasco, David Prada Crespo, María Luisa Delgado Losada, Christian Montejo Rubio, Mercedes Montenegro-Peña   +4 more
doaj   +1 more source

Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment

Nature Communications, 2020
Cognitive decline is one of the complications of type 2 diabetes (T2D). Intermittent fasting (IF) is a promising dietary intervention for alleviating T2D symptoms, but its protective effect on diabetes-driven cognitive dysfunction remains elusive.
Zhigang Liu, Xiaoshuang Dai, Hongbo Zhang, Renjie Shi, Yan Hui, Xin Jin, Wentong Zhang, Luanfeng Wang, Qianxu Wang, Danna Wang, Jia Wang, Xintong Tan, Bo Ren, Xiaoning Liu, Tong Zhao, Jiamin Wang, Junru Pan, Tian Yuan, Chuanqi Chu, Lei Lan, F. Yin, E. Cadenas, Lin Shi, Shancen Zhao, Xuebo Liu   +24 more
semanticscholar   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Event-Related Potentials in Relation to Risk-Taking: A Systematic Review

Frontiers in Behavioral Neuroscience, 2018
Event-related potentials (ERPs) have been used to investigate neural mechanisms underlying risk-related decisions over the last 16 years. We aimed to systematically evaluate associations between risk-taking and ERP components elicited during decisions ...
Dilushi Chandrakumar, Daniel Feuerriegel, Daniel Feuerriegel, Stefan Bode, Megan Grech, Hannah A. D. Keage   +5 more
doaj   +1 more source

A RE-AIM Analysis of an Intergenerational Dementia Education Program

Frontiers in Public Health, 2020
Objectives: Children often have a lack of dementia understanding and poor attitudes toward people with dementia. Intergenerational programs are increasingly common, but the effects on knowledge and attitudes related to dementia are mixed, especially in ...
Ashleigh E. Smith, Ashleigh E. Smith, Georgina L. Kamm, Samantha Lai, Melissa J. Hull, Melissa J. Hull, Jess R. Baker, Rachel Milte, Julie Ratcliffe, Tobias Loetscher, Hannah A. D. Keage   +10 more
doaj   +1 more source