Results 111 to 120 of about 363,866 (292)

Late‐midlife lifestyle and brain and cognitive changes in individuals on the AD versus non‐AD continuum

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION We investigated whether a composite measure of late‐midlife lifestyle was associated with (1) longitudinal brain changes and (2) cognitive changes when adjusting for these brain changes. METHODS We used linear mixed models to examine whether
Julie E. Oomens, Karly A. Cody, Lianlian Du, Erin M. Jonaitis, Rachel L. Studer, Nathaniel A. Chin, Sebastian Köhler, Pieter Jelle Visser, Stephanie J. B. Vos, Rebecca E. Langhough, Willemijn J. Jansen, Sterling C. Johnson   +11 more
doaj   +1 more source

Trajectories of recall memory as predictive of hearing impairment: A longitudinal cohort study.

PLoS ONE, 2020
ObjectivesAccumulating evidence points to a relationship between hearing function and cognitive ability in later life. However, the exact mechanisms of this relationship are still unclear. This study aimed to characterise latent cognitive trajectories in
Asri Maharani, Piers Dawes, James Nazroo, Gindo Tampubolon, Neil Pendleton, SENSE-Cog WP1 group   +5 more
doaj   +1 more source

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source

Trajectories of cognitive ability and attitudes toward own aging in older adults: a conditional parallel latent growth model

BMC Geriatrics
Background Good cognitive function and positive attitudes toward own aging (ATOA) are important factors in promoting healthy aging. However, existing research has rarely explored the interrelationship between the developmental trajectories of cognitive ...
Songli Mei, Chengbin Zheng, Leilei Liang, Marhaba Kiyum, Junsong Fei, Tongshuang Yuan, Huimin Wang, Jiaying Gao, Xinli Lin   +8 more
doaj   +1 more source

A Connectionist Model of Spatial Knowledge Acquisition in a Virtual Environment [PDF]

, 2003
This paper proposes the use of neural networks as a tool for studying navigation within virtual worlds. Results indicate that network learned to predict the next step for a given trajectory, acquiring also basic spatial knowledge in terms of landmarks ...
O'Hare, G.M.P., Reilly, R., Sas, Corina
core  

Bayesian nonparametric hierarchical modeling for multiple membership data in grouped attendance interventions

, 2013
We develop a dependent Dirichlet process (DDP) model for repeated measures multiple membership (MM) data. This data structure arises in studies under which an intervention is delivered to each client through a sequence of elements which overlap with ...
Paddock, Susan M., Savitsky, Terrance D.
core   +1 more source

The longitudinal association between dyslipidemia and cognitive trajectory

Journal of Alzheimer’s Disease
Background The literature on dyslipidemia and cognitive trajectories among cognitively unimpaired (CU) persons remains inconclusive. Objective To investigate the association between baseline dyslipidemia and ...
Anna Pink, Janina Krell-Roesch, Jeremy A Syrjanen, Maria Vassilaki, Julie A Fields, Bernhard Iglseder, Elmar Aigner, Walter K Kremers, Clifford R Jack, Susan B Racette, Ronald C Petersen, Yonas E Geda   +11 more
openaire   +2 more sources

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Rethinking Phylogeny and Ontogeny in Hominin Brain Evolution [PDF]

, 2012
Theories of hominin and human cognitive evolution have traditionally focused on the phylogeny of the human brain, and on comparisons of human and primate brains in relation to social or ecological variables.
Coward, Fiona
core  

Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez, Monica Ferrer Socorro, Kathryn Yang, Nicole Battaglia, Zainab Zaman, Mariko Bennett, Adeline Vanderver, Pui Y. Lee, Lauren A. Henderson, Milena M. Andzelm, Darius Ebrahimi‐Fakhari   +10 more
wiley   +1 more source