Results 121 to 130 of about 2,345,325 (297)

Troponin T and Neurofilament Light Chain Levels as Complementary Biomarkers of Disease Accumulation and Aggressiveness in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous neurodegenerative disease requiring reliable biomarkers to improve patient stratification and trial design. While serum neurofilament light chain (sNfL) reflects neuroaxonal stress and disease aggressiveness, troponin T (TnT) may capture complementary aspects of ...
Julia Sellin, Sofia Waldorf, Janina von der Gablentz, Torsten Grehl, Huelya Nazlican, Thomas Meyer, Julian Grosskreutz, Patrick Weydt, Sarah Bernsen   +8 more
wiley   +1 more source

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source

Cardiometabolic multimorbidity, social activity, and joint trajectories of physical disability, depressive symptom, and cognitive function in mid-to-late life: a multicohort study

BMC Medicine
Background There is limited evidence on the long-term associations between cardiometabolic multimorbidity (CMM) and multiple domains of functioning, and the potential role of social activity in these associations.
Yue Zhang, Yaguan Zhou, Mika Kivimäki, Julianne Holt-Lunstad, Rodrigo M. Carrillo-Larco, Xiaolin Xu   +5 more
doaj   +1 more source

Trajectories of cognitive function development and predictive factors in disabled middle-aged and older adults

Frontiers in Public Health
ObjectiveTo explore the trajectories of cognitive function development and predictive factors in disabled middle-aged and older adults.MethodsUtilizing data from 983 disabled middle-aged and older adults in the China Health and Retirement Longitudinal ...
Jiaxue Pang, Yang Xu, Qiankun Liu, Juju Huang, Pengyao Li, Li Ma, Chunlu Zeng, Xiaoqing Ma, Hui Xie   +8 more
doaj   +1 more source

Reserves, Injury Severity, and Outcomes in Traumatic Brain Injury: A CENTER‐TBI Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Reserve refers to the brain's ability to maintain function after an injury and strongly relates to traumatic brain injury (TBI) outcomes. This study examined (1) whether associations between pre‐injury reserve proxies and outcomes differed across injury severity categories, and (2) whether the impact of injury severity varied across ...
Natascha Ekdahl, Marika C. Möller, Lindsay Wilson, Anne Vik, Toril Skandsen, Jonas Stenberg, CENTER‐TBI participants and investigators   +6 more
wiley   +1 more source

Associations between depressive symptoms and cognitive function in China older adults based on a dual-trajectory model

BMC Public Health
Background Cognitive decline and depressive symptoms often co-occur in older adults, but research on the trajectories of these two conditions and their interrelationships remains limited.
Xiaoqing Zhao, Ya Zhang, Ruxu Ge, Lihong Ji, Zhiwei Dong, Hongzhi Zhang, Xue Bai, Shanquan Chen, Haiyan Li, Qi Jing, Wengui Zheng   +10 more
doaj   +1 more source

Data‐Driven SuStaIn Model of Disability Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether ordinal Subtype and Stage Inference (SuStaIn) applied to routine ALSFRS‐R item scores can identify reproducible disability progression patterns in amyotrophic lateral sclerosis (ALS) and provide clinically meaningful staging.
Giammarco Milella, Veria Vacchiano, Vittorio Velucci, Stefano Zoccolella, Rocco Liguori, Giovanni Defazio   +5 more
wiley   +1 more source

COGNITIVE AND MOTOR RESOURCES AS POTENTIAL PREDICTORS OF COGNITIVE CHANGES IN AGING: A LONGITUDINAL STUDY.

reservedCognitive and Motor reserves are widely and increasingly recognized as protective factors in the context of age-related cognitive decline. Cognitive reserve (CR), shaped by lifetime intellectual engagement, and motor reserve (MR), reflecting ...
SAGGIN, ANNA
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Cognitive contact linguistics: placing usage, meaning and mind at the core of contact-induced variation and change Cognitive linguistics research ;, 62./ edited by Eline Zenner, Ad Backus, Esme Winter-Froemel.

, 2019
"The collection of papers presented in this volume, which grew out of a theme session organised at the 13th International Cognitive Linguistics Conference (Northumbria, UK, July 2015)"--Page vii.Includes bibliographical references and index.1 online ...
Backus Ad, Winter-Froemel Esme, Zenner Eline   +2 more
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Theory of cognitive distortions: personalisation [PDF]

, 2009
In a previous paper (Compléments pour une théorie des distorsions cognitives, Journal de Thérapie Comportementale et Cognitive, 2007), we did present some elements aimed at contributing to a general theory of cognitive distortions. Based on the reference
Franceschi, Dr Paul
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