Results 51 to 60 of about 3,274,533 (303)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Detection of partially coherent optical emission sources [PDF]

, 2000
Detection of airborne optical emission sources in Infrared Search and Track (IRST) systems is usually carried out using the blackbody temperature or emissivity difference between the emission source and the background.
Coutinho, RC, French, HA, Selviah, DR
core  

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Blind Joint Soft-Detection Assisted Slow Frequency-Hopping Multicarrier DS-CDMA [PDF]

, 2000
A novel multiple-access scheme based on slow frequency-hopping multicarrier direct-sequence, code-division multiple access (SFH/MC DS-CDMA) is proposed and investigated, which can be rendered compatible with the existing second-generation narrow-band ...
Lie-Liang Yang, L. Hanzo, Yang, L-L., Hanzo, L.   +3 more
core   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A Novel Spectral-Efficient Coherent Radio-Over-Fiber Link With Linear Digital-Phase Demodulation

IEEE Photonics Journal, 2020
In this paper, a novel spectral-efficient coherent radio-over-fiber (RoF) link with linear digital phase demodulation is proposed and experimentally demonstrated. At the transmitter, to make an efficient use of the optical power and spectra, an intensity-
Huixing Zhang, Aijun Wen, Wu Zhang, Weipeng Zhang, Weile Zhai, Zhaoyang Tu   +5 more
doaj   +1 more source

High-sensitivity detection of narrowband light in a more intense broadband background using coherence interferogram phase [PDF]

, 2006
This paper describes an optical interferometric detection technique,. known as the interferogram phase step shift, which detects narrowband, coherent, and partially coherent light in more intense broadband incoherent background light using changes in the
Coutinho, RC, Griffiths, HD, Selviah, DR
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Joint Implementation Method for Clutter Suppression and Coherent Maneuvering Target Detection Based on Sub-Aperture Processing with Airborne Bistatic Radar

Remote Sensing
An airborne bistatic radar working in downward-looking mode confronts two major challenges for low-altitude target detection. One is range cell migration (RCM) and Doppler migration (DM) resulting from the relative motion of the radar and target.
Zhi Sun, Xingtao Jiang, Haonan Zhang, Jiangyun Deng, Zihao Xiao, Chen Cheng, Xiaolong Li, Guolong Cui   +7 more
doaj   +1 more source