Results 231 to 240 of about 31,924 (248)
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Science Signaling, 2002
Cohesin attaches chromosomes to the mitotic spindle and allows separation of sister chromatids at anaphase. Phosphorylation of cohesin by a Polo-like kinase in yeast enhances cohesin degradation by separase at the onset of anaphase. However, in other eurkaryotes, the bulk of cohesin is removed from chromosomes earlier in mitosis (prophase ...
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Cohesin attaches chromosomes to the mitotic spindle and allows separation of sister chromatids at anaphase. Phosphorylation of cohesin by a Polo-like kinase in yeast enhances cohesin degradation by separase at the onset of anaphase. However, in other eurkaryotes, the bulk of cohesin is removed from chromosomes earlier in mitosis (prophase ...
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Current Opinion in Genetics & Development
Chromosomes in eukaryotic cells undergo compaction at multiple levels and are folded into hierarchical structures to fit into the nucleus with limited dimensions. Three-dimensional genome organization needs to be coordinated with chromosome-templated processes, including DNA replication and gene transcription.
Shutao Qi, Zhubing Shi, Hongtao Yu
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Chromosomes in eukaryotic cells undergo compaction at multiple levels and are folded into hierarchical structures to fit into the nucleus with limited dimensions. Three-dimensional genome organization needs to be coordinated with chromosome-templated processes, including DNA replication and gene transcription.
Shutao Qi, Zhubing Shi, Hongtao Yu
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Cohesin in determining chromosome architecture
Experimental Cell Research, 2012Cells use ring-like structured protein complexes for various tasks in DNA dynamics. The tripartite cohesin ring is particularly suited to determine chromosome architecture, for it is large and dynamic, may acquire different forms, and is involved in several distinct nuclear processes.
Christian H, Haering, Rolf, Jessberger
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Cohesin in haematopoiesis and leukaemia
Current Opinion in Hematology, 2018Purpose of review Disturbance of the delicate balance between self-renewal and differentiation in haematopoietic stem cells (HSCs) can lead to both leukaemia and bone marrow failure. The regulation of this balance in HSC biology has been intensely investigated in several model systems, and lately the importance of epigenetic ...
Roman, Galeev, Jonas, Larsson
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Cohesin, a chromatin engagement ring
Current Opinion in Cell Biology, 2013Cohesin is a four subunit complex, conserved from yeast to man, with the ability to hold together two DNA segments within its ring-shaped structure. When the two segments belong to sister chromatids, cohesin is mediating cohesion, which is essential for chromosome segregation in mitosis and meiosis and for homologous DNA repair.
Silvia, Remeseiro, Ana, Losada
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