Results 221 to 230 of about 26,113 (251)
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Cohesin mutations in myeloid malignancies
Blood, 2021Abstract Cohesin is a multisubunit protein complex that forms a ring-like structure around DNA. It is essential for sister chromatid cohesion, chromatin organization, transcriptional regulation, and DNA damage repair and plays a major role in dynamically shaping the genome architecture and maintaining DNA integrity.
Johann-Christoph Jann, Zuzana Tothova
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Science's STKE, 2002
Cohesin attaches chromosomes to the mitotic spindle and allows separation of sister chromatids at anaphase. Phosphorylation of cohesin by a Polo-like kinase in yeast enhances cohesin degradation by separase at the onset of anaphase. However, in other eurkaryotes, the bulk of cohesin is removed from chromosomes earlier in mitosis (prophase ...
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Cohesin attaches chromosomes to the mitotic spindle and allows separation of sister chromatids at anaphase. Phosphorylation of cohesin by a Polo-like kinase in yeast enhances cohesin degradation by separase at the onset of anaphase. However, in other eurkaryotes, the bulk of cohesin is removed from chromosomes earlier in mitosis (prophase ...
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Current Opinion in Genetics & Development
Chromosomes in eukaryotic cells undergo compaction at multiple levels and are folded into hierarchical structures to fit into the nucleus with limited dimensions. Three-dimensional genome organization needs to be coordinated with chromosome-templated processes, including DNA replication and gene transcription.
Shutao Qi, Zhubing Shi, Hongtao Yu
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Chromosomes in eukaryotic cells undergo compaction at multiple levels and are folded into hierarchical structures to fit into the nucleus with limited dimensions. Three-dimensional genome organization needs to be coordinated with chromosome-templated processes, including DNA replication and gene transcription.
Shutao Qi, Zhubing Shi, Hongtao Yu
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Detection of Cohesin SUMOylation In Vivo
2016Cohesin is a protein complex with key roles in chromosome biology, from chromatid segregation to DNA repair. Cohesin function is regulated by several posttranslational modifications, including phosphorylation, acetylation, ubiquitylation, and SUMOylation.
Marcelino, Bermúdez-López +1 more
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Cohesin and Cdk1: an anaphase barricade
Nature Cell Biology, 2010Separation of sister chromatids at anaphase in metazoan cells requires only the cleavage of the kleisin subunit of centromeric cohesin, but efficient poleward movement of separated sisters requires the associated loss in Cdk1 activity. Activation of the anaphase-promoting complex/cyclosome ensures these events are coordinated.
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Cohesin maintains replication timing to suppress DNA damage on cancer genes
Nature Genetics, 2023Jinchun Wu +12 more
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Coordination of cohesin and DNA replication observed with purified proteins
NatureYasuto Murayama +5 more
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Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms
Molecular Cell, 2023Kota Nagasaka +2 more
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Cohesin: behind dynamic genome topology and gene expression reprogramming
Trends in Cell Biology, 2021Sammer Marzouk +2 more
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