Results 211 to 220 of about 26,113 (251)
CTCF and R-loops are boundaries of cohesin-mediated DNA looping
Molecular Cell, 2023 Cohesin and CCCTC-binding factor (CTCF) are key regulatory proteins of three-dimensional (3D) genome organization. Cohesin extrudes DNA loops that are anchored by CTCF in a polar orientation.
Edward J Banigan +2 more
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2013
Sister chromatid cohesion depends on cohesin, a tripartite complex that forms ring structures to hold sister chromatids together in mitosis and meiosis. Meiocytes feature a multiplicity of distinct cohesin proteins and complexes, some meiosis specific, which serve additional functions such as supporting synapsis of two pairs of sister chromatids and ...
François, McNicoll +2 more
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Sister chromatid cohesion depends on cohesin, a tripartite complex that forms ring structures to hold sister chromatids together in mitosis and meiosis. Meiocytes feature a multiplicity of distinct cohesin proteins and complexes, some meiosis specific, which serve additional functions such as supporting synapsis of two pairs of sister chromatids and ...
François, McNicoll +2 more
openaire +2 more sources
DNA loop extrusion by human cohesin
Science, 2019Cohesin extrudes DNA loops DNA is folded into loops in eukaryotic cells by a process that depends on a ring-shaped adenosine triphosphatase complex called cohesin. Davidson et al. and Kim et al.
I. Davidson +5 more
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Cohesin in haematopoiesis and leukaemia
Current Opinion in Hematology, 2018Purpose of review Disturbance of the delicate balance between self-renewal and differentiation in haematopoietic stem cells (HSCs) can lead to both leukaemia and bone marrow failure. The regulation of this balance in HSC biology has been intensely investigated in several model systems, and lately the importance of epigenetic ...
Roman, Galeev, Jonas, Larsson
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A Role for Chromatin Remodeling in Cohesin Loading onto Chromosomes [PDF]
Molecular Cell, 2019 [EN]Cohesin is a conserved, ring-shaped protein complex that topologically embraces DNA. Its central role in genome organization includes functions in sister chromatid cohesion, DNA repair, and transcriptional regulation. Cohesin loading onto chromosomes
Sofía Muñoz +2 more
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Cohesin and chromatin organisation
Current Opinion in Genetics & Development, 2012Cohesin defines the topology of chromosomes in mitosis and meiosis by holding sister chromatids together; more recently a role for cohesin in chromatin organisation and gene expression in interphase has emerged.
Seitan, VC, Merkenschlager, M
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Regulators of the Cohesin Network
Annual Review of Biochemistry, 2010Chromosome cohesion is the term used to describe the cellular process in which sister chromatids are held together from the time of their replication until the time of separation at the metaphase to anaphase transition. In this capacity, chromosome cohesion, especially at centromeric regions, is essential for chromosome segregation.
Bo, Xiong, Jennifer L, Gerton
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Cohesin in development and disease
Development, 2013Cohesin is a ring-shaped complex, conserved from yeast to human, that was named for its ability to mediate sister chromatid cohesion. This function is essential for chromosome segregation in both mitosis and meiosis, and also for DNA repair. In addition, more recent studies have shown that cohesin influences gene expression during development through ...
Silvia, Remeseiro +2 more
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Sister chromatid cohesion is mediated by individual cohesin complexes
ScienceEukaryotic genomes are organized by loop extrusion and sister chromatid cohesion, both mediated by the multimeric cohesin protein complex. Understanding how cohesin holds sister DNAs together, and how loss of cohesion causes age-related infertility in ...
Fena Ochs +9 more
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Cryo-EM structure of the human cohesin-NIPBL-DNA complex
Science, 2020A blueprint to understand cohesin Cohesin is a multiprotein complex that entraps sister chromatids for chromosome segregation and regulates transcription by extruding DNA loops to shape DNA organization. Shi et al.
Zhu-Bing Shi +3 more
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