Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Long-term treatment for Laron syndrome with IGF-1 injection over 22 years in Saudi: A cohort study [PDF]
Abdullah Al‐Ashwal +4 more
openalex +1 more source
Cumulative exposure to high remnant-cholesterol concentrations increases the risk of cardiovascular disease in patients with hypertension: a prospective cohort study [PDF]
, 2023 Weiqiang Wu +13 more
openalex +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
A diminishing population whose every cohort more than replaces itself [PDF]
We observe that a dynamic population model can have period fertility that is always below replacement and cohort fertility that is always above replacement.
Robert Schoen, Stefan H. Jonsson
core
Allergy to polyethylene glycol and polysorbates in a patient cohort: Diagnostic work‐up and decision points for vaccination during the COVID‐19 pandemic [PDF]
, 2022 Charlotte G. Mortz +5 more
openalex +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Prevalence, risk factors, and mortality of COPD in young people in the USA: results from a population-based retrospective cohort [PDF]
, 2023 Zihui Wang +17 more
openalex +1 more source
Cohort profile: the Shanghai Birth Cohort [PDF]
International Journal of Epidemiology, 2019 Jun Zhang +30 more
openaire +2 more sources