Results 181 to 190 of about 3,632,413 (364)
COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study
The Lancet Child & Adolescent Health, 2020 Florian Götzinger, B. Santiago-García, A. Noguera-Julian, M. Lanaspa, L. Lancella, F. C. Calò Carducci, Natalia Gabrovska, S. Velizarova, Petra Prunk, Veronika Osterman, U. Krivec, A. Lo Vecchio, D. Shingadia, A. Soriano-Arandes, S. Melendo, M. Lanari, L. Pierantoni, N. Wagner, A. L'Huillier, U. Heininger, N. Ritz, S. Bandi, Nina Krajcar, S. Roglić, Mar Santos, Christelle Christiaens, M. Creuven, D. Buonsenso, S. Welch, M. Bogyi, F. Brinkmann, M. Tebruegge, Jasmin Angela Angelika Roland Volker Daniela S. Anna Beno Pfefferle Zacharasiewicz Berger Berger Strenger Ko, J. Pfefferle, A. Zacharasiewicz, A. Berger, R. Berger, V. Strenger, Daniela S. Kohlfürst, A. Zschocke, B. Bernar, B. Simma, E. Haberlandt, Christina Thir, A. Biebl, K. Vanden Driessche, T. Boiy, Daan Van Brusselen, A. Bael, S. Debulpaep, P. Schelstraete, I. Pavić, U. Nygaard, J. P. Glenthoej, Lise Heilmann Jensen, Ilona Lind, Mihhail Tistsenko, Ü. Uustalu, Laura Buchtala, Stephanie Thee, R. Kobbe, Cornelius Rau, N. Schwerk, M. Barker, M. Tsolia, Irini Eleftheriou, Patrick Gavin, O. Kozdoba, Borbála Zsigmond, P. Valentini, Inga Ivaskeviciene, Rimvydas Ivaškevičius, V. Vilc, E. Schölvinck, A. Rojahn, A. Smyrnaios, C. Klingenberg, I. Carvalho, Andreia Ribeiro, A. Starshinova, I. Solovič, L. Falcón, O. Neth, Laura Minguell, M. Bustillo, A. M. Gutiérrez-Sánchez, B. Guarch Ibáñez, Francesc Ripoll, Beatriz Soto, K. Kötz, Petra Zimmermann, H. Schmid, F. Zucol, A. Niederer, Michael Buettcher, B. Cetin, O. Bilogortseva, Vera Chechenyeva, A. Demirjian, F. Shackley, L. McFetridge, L. Speirs, C. Doherty, L. Jones, P. Mcmaster, C. Murray, F. Child, Y. Beuvink, N. Makwana, E. Whittaker, Amanda Williams, K. Fidler, J. Bernatoniene, R. Song, Z. Oliver, A. Riordan +115 moresemanticscholar +1 more sourceA large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival
Molecular Oncology, EarlyView.There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas +20 morewiley +1 more sourceA cohort profile of the Graham Roberts study cohort
Frontiers in OncologyPurposeThe Graham Roberts Study was initiated in 2018 and is the first Trials Within Cohorts (TwiCs) study for bladder cancer. Its purpose is to provide an infrastructure for answering a breadth of research questions, including clinical, mechanistic, and supportive care centred questions for bladder cancer patients.ParticipantsAll consented patients ...Beth Russell, Poppy Leech, Harriet Wylie, Charlotte Louise Moss, Anna Haire, Deborah Enting, Suzanne Amery, Kathryn Chatterton, Muhammad Shamim Khan, Ramesh Thurairaja, Rajesh Nair, Sachin Malde, Kate Smith, Cheryl Gillett, Debra Josephs, Elias Pintus, Sarah Rudman, Simon Hughes, Clare Relton, Mieke Van Hemelrijck +19 moreopenaire +3 more sourcesMultidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher +11 morewiley +1 more sourceCohort profile: the Shanghai Birth Cohort [PDF]
International Journal of Epidemiology, 2019 Jun Zhang, Ying Tian, Weiye Wang, Fengxiu Ouyang, Jian Xu, Xiaodan Yu, Zhongcheng Luo, Fan Jiang, Hong Huang, Xiaoming Shen, Kun Sun, Weiping Xu, Lin Zhang, Yin Huang, Jinsong Zhang, Chonghuai Yan, Lisong Shen, Yixiao Bao, Weiwei Chen, Huijuan Zhang, Chuanliang Tong, Yiwen Zhang, Guangjun Yu, Jinjin Chen, Yu Zhang, Xiaotian Li, Haidong Cheng, Qinying Zhang, Tao Duan, Jing Hua, Hua Peng +30 moreopenaire +2 more sourcesGermline variants in CDKN2A wild‐type melanoma prone families
Molecular Oncology, EarlyView.Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic Gjertrud T. Iversen, Marie Loeng, Amalie Lund Holth, Per E. Lønning, Jürgen Geisler, Stian Knappskog +5 morewiley +1 more source