Results 211 to 220 of about 5,101,614 (337)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Medial temporal lobe atrophy is associated with age and pathologies, especially small vessel disease. [PDF]

Sci Rep
van Westen D, Stomrud E, Lorenzini L, Palmqvist S, Barkhof F, Hansson O, Spotorno N.   +6 more
europepmc   +1 more source

Cohort Profile: The Swedish National March Cohort [PDF]

International Journal of Epidemiology, 2016
Trolle Lagerros, Y, HANTIKAINEN, ESSI MARJATTA, Mariosa, D, Ye, W, Adami, H, Grotta, A, Ghilotti, F, BELLOCCO, RINO   +7 more
openaire   +2 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Clinical and translational results from a phase 1 trial of gemcitabine/nab-paclitaxel with nivolumab/ipilimumab or hydroxychloroquine/ipilimumab in untreated metastatic pancreatic adenocarcinoma. [PDF]

J Immunother Cancer
O'Reilly EM, Cabanski CR, Lyman JP, Wainberg ZA, Fisher GA, Wolff RA, Ko AH, O'Hara MH, Spencer CN, Yu JX, Da Silva DM, Padrón LJ, Arnott J, Fairchild J, Moore JS, Peng B, Hoos WA, O'Donnell-Tormey J, Boffo S, Dugan U, Kimmelman AC, Amaravadi RK, Vonderheide RH.   +22 more
europepmc   +1 more source

Association between a single-pass whole-body computed tomography policy and survival after blunt major trauma: a retrospective cohort study [PDF]

, 2011
Martin Hutter, Alexander Woltmann, Christian Hierholzer, Christian Gärtner, V. Bühren, Dirk Stengel   +5 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Cohort Profile: The Urmia Lake Cohort Study (ULCS)

International Journal of Epidemiology, 2022
Javad Aghazadeh-Attari, Hossein Poustchi, Davoud Vahabzadeh, Ramin Shakeri, Rasool Entezar Mahdi, Habibollah Pirnejad, Sareh Eghtesad, Zahra Mohammadi, Maryam Sharafkhah, Amaneh Shayanrad, Neda Valizadeh, Mohammadreza Pashaei, Nilsa Dourandish, Maryam Majidinia, Marjan Kouhnavard, Jamal Ahmadzadeh, Ali Sadaghyanifar, Iraj Mohebbi   +17 more
openaire   +2 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source