Results 51 to 60 of about 33,542 (293)

TMC4 localizes to multiple taste cell types in the mouse taste papillae

open access: yesFEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata   +6 more
wiley   +1 more source

Solvability of fractional-order multi-point boundary-value problems at resonance on the half-line

open access: yesElectronic Journal of Differential Equations, 2012
In this article, we study a fractional differential equation. By constructing two special Banach spaces and establishing an appropriate compactness criterion, we present some existence results about the boundary-value problem at resonance via Mawhin's
Yi Chen, Zhanmei Lv
doaj  

Coincidence degree and fractional boundary value problems with impulses

open access: yesComputers & Mathematics with Applications, 2012
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Ambrosetti–Prodi Periodic Problem Under Local Coercivity Conditions

open access: yesAdvanced Nonlinear Studies, 2018
In this paper we focus on the periodic boundary value problem associated with the Liénard differential equation x′′+f⁢(x)⁢x′+g⁢(t,x)=s{x^{\prime\prime}+f(x)x^{\prime}+g(t,x)=s}, where s is a real parameter, f and g are continuous functions and g is T ...
Sovrano Elisa, Zanolin Fabio
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

open access: yesFEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde   +3 more
wiley   +1 more source

Existence of solutions for four-point resonance boundary-value problems on time scales

open access: yesElectronic Journal of Differential Equations, 2015
By using Mawhin's continuation theorem, we prove the existence of solutions for a class of multi-point boundary-value problem under different resonance conditions on time scales.
Ning Wang, Hui Zhou, Liu Yang
doaj  

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

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