Results 51 to 60 of about 21,356 (260)
Journal of Personalized Medicine, 2023 The pathophysiology of atopic dermatitis (AD) is complex, multifactorial, and not fully understood. Genes encoding collagens, the most abundant proteins in the extracellular matrix (ECM), may play a potential role in the pathogenesis of AD. Our study aimed to estimate the associations between Col3A1/rs1800255, Col6A5 /29rs12488457, and Col8A1 ...
Krzysztof Szalus +5 more
openaire +2 more sources
Gene targeting strategy and ES screen for Col3a1 knock-in mice generation.
, 2022 A. Gene targeting strategy used for generating the Col3a1+/G182R mutated allele. The WT and targeted alleles are shown before and after FLP recombination (with and without the pgk-neorcassette respectively).
Irmine Loisel-Ferreira (12197672) +11 more
core +1 more source
Advanced Materials, EarlyView.In this study, we show that retinal matrix stiffness is increased in diabetic mice. Using engineered human vascular models with controlled matrix stiffness, we demonstrate that stiffening activates focal adhesion kinase (FAK) signaling in pericytes, suppresses Notch signaling, and disrupts vascular morphology.
Emily Warren +6 more
wiley +1 more source
PLoS Genetics, 2022 Vascular Ehlers-Danlos syndrome is a rare inherited disorder caused by genetic variants in type III collagen. Its prognosis is especially hampered by unpredictable arterial ruptures and there is no therapeutic consensus.
Anne Legrand +11 more
doaj +1 more source
Programmable Paracrine‐Mimetic Microneedle System for Temporal Regulation of Cardiac Repair
Advanced Science, EarlyView.Temporal signaling is encoded into a programmable paracrine‐mimetic microneedle patch via tris(2,2'‐bipyridyl)dichlororuthenium(II) hexahydrate/sodium persulfate‐tuned hydrogel microparticles that deliver TGF‐β, IGF‐1, and VEGF over phase‐matched 7‐, 14‐, and 28‐day windows.
Yichen Dai +18 more
wiley +1 more source
Collagen Gene Variants and Anterior Cruciate Ligament Rupture in the Korean Population [PDF]
운동과학PURPOSE Anterior cruciate ligament rupture (ACLR) is a common knee ligament injury that occurs in sports. The precise etiology of ACLR remains unknown. Previous studies in various ethnic groups have confirmed an association between genetic variants and ...
Ki-Hoon Seong +5 more
doaj +1 more source
NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension [PDF]
Science Translational Medicine, 2018 TGF-β–independent oxidative modification of NEDD9 at Cys 18 promotes vascular fibrosis and the pathobiology of pulmonary arterial hypertension.
Andriy O. Samokhin +28 more
openaire +4 more sources
Advanced Science, EarlyView.4D bioprinted hydrogel loaded with FGF2‐modified extracellular vesicles (4D@F‐EVs) targets dermal fibroblasts and elevates local wound FGF2 levels via sustained release of F‐EVs. It activates PI3K‐Akt signaling, restores critical KGF+ fibroblast–KGFR+ keratinocyte crosstalk, enhances robust angiogenesis and collagen deposition to efficiently repair ...
Xiaomin Wang +19 more
wiley +1 more source
Advanced Science, EarlyView.A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li +9 more
wiley +1 more source
Lnc-GULP1–2:1 affects granulosa cell proliferation by regulating COL3A1 expression and localization
Journal of Ovarian Research, 2021 Backgrounds Long non-coding RNA is a novel group of non-protein coding transcripts over 200 nt in length. Recent studies have found that they are widely involved in many pathological and physiological processes.
Guidong Yao +10 more
doaj +1 more source