Results 71 to 80 of about 21,356 (260)

An integrated analysis of bulk and single-cell sequencing data reveals that EMP1+/COL3A1+ fibroblasts contribute to the bone metastasis process in breast, prostate, and renal cancers

Frontiers in Immunology, 2023
IntroductionBone metastasis (BoM) occurs when cancer cells spread from their primary sites to a bone. Currently, the mechanism underlying this metastasis process remains unclear.MethodsIn this project, through an integrated analysis of bulk-sequencing ...
Haoyuan Du, Hua Wang, Yuwei Luo, Yang Jiao, Jiajun Wu, Shaowei Dong, Dong Du   +6 more
doaj   +1 more source

Unravelling the Distinct Phenotype and Mechanosensitive Properties of Different Tendon Cell Populations

Advanced Science, EarlyView.
Tendon interfascicular and fascicular matrix cells are isolated and cultured, revealing distinct phenotypes and mechanosensitive responses. Interfascicular matrix cells exhibit marked stiffness‐dependent phenotypic plasticity, whereas fascicular matrix cells remain comparatively stable.
S. E. Grossemy, D. E. Zamboulis, N. S. Khatib, M. R. Fazal, C. C. Gains, A. Giannopoulos, T. Hopkins, C. Bevan, Y. Aggarwal, M. M. Knight, H. R. C. Screen   +10 more
wiley   +1 more source

Penetrance of cortical dysplasia in Col3a1 mice.

, 2013
Penetrance of cortical dysplasia in Col3a1 mice.
Rong Luo (187167), Natalie Strokes (189296), Sung-Jin Jeong (336209), Xianhua Piao (189302), Shihong Li (336210)   +4 more
core   +1 more source

Data_Sheet_1_Case report: Characterization of a rare pathogenic variant associated with loss of COL3A1 expression in vascular Ehlers Danlos syndrome.PDF

, 2022
The vascular subtype of Ehlers Danlos Syndrome (vEDS) is a rare connective tissue disorder characterized by spontaneous arterial, bowel or organ rupture.
Ashikh Seethy (7382295), Janvie Manhas (690626), Shivanand Gamanagatti (13935549), Uma Kumar (4808583), Sudip Sen (690627), Lov Raj Lohani (13935546)   +5 more
core   +1 more source

Interleukin‐1α Mediates Pancreatic Fibroblast Activation, Regulates Immune Cell Recruitment and Fibrosis in Acute and Chronic Pancreatitis

Advanced Science, EarlyView.
During pancreatitis, IL‐1α is released from necrotic acinar cells. In response to IL‐1α, pancreatic fibroblasts release chemokines and cytokines that regulate the recruitment of immune cells to the damaged organ. Furthermore, IL‐1α primes fibroblasts, resulting in increased tissue fibrosis during chronic pancreatitis.
Hala Mazloum, Shenja Buchholz, Hanna Schifter, Sabine Ameling, Leif Steil, Ben Lewin Becker, Elke Hammer, Georg Homuth, Uwe Völker, Barbara M. Bröker, Lukas Zierke, Frank Ulrich Weiss, Juliane Glaubitz, Matthias Sendler   +13 more
wiley   +1 more source

Vascular Injury In Col3A1+/- Mice Model of Vascular Ehler-Danlos Syndrome [PDF]

, 2018
Vascular type of Ehlers-Danlos Syndrome (vEDS) is an inherited cardiovascular disease affecting the middle to large sized arteries, with an incidence rate of 1/5000.
ZHOU, Ping, MS
core   +1 more source

Smad3 inactivation and MiR-29b upregulation mediate the effect of carvedilol on attenuating the acute myocardium infarction-induced myocardial fibrosis in rat. [PDF]

PLoS ONE, 2013
Carvedilol, a nonselective β-adrenoreceptor antagonist, protects against myocardial injury induced by acute myocardium infarction (AMI). The mechanisms underlying the anti-fibrotic effects of carvedilol are unknown.
Jie-Ning Zhu, Ren Chen, Yong-Heng Fu, Qiu-Xiong Lin, Shuai Huang, Lin-Lin Guo, Meng-Zhen Zhang, Chun-Yu Deng, Xiao Zou, Shi-Long Zhong, Min Yang, Jian Zhuang, Xi-Yong Yu, Zhi-Xin Shan   +13 more
doaj   +1 more source

Case report: Complex arterial findings in vascular ehlers-danlos syndrome with a novel COL3A1 variant and death at young age

Frontiers in Cardiovascular Medicine, 2023
Vascular Ehlers-Danlos syndrome (vEDS) is a genetic disease caused by a pathogenic mutation in the COL3A1 gene. Despite its severe course, the rarity and extreme clinical variability of the disease can pose significant obstacles to a timely diagnosis ...
Jacopo Taurino, Emanuele Micaglio, Annalisa Russo Raucci, Monica Zanussi, Massimo Chessa, Massimo Chessa, Nathasha Samali Udugampolage, Paola Carrera, Paola Carrera, Carlo Pappone, Carlo Pappone, Alessandro Pini   +11 more
doaj   +1 more source

Data_Sheet_2_Case report: Characterization of a rare pathogenic variant associated with loss of COL3A1 expression in vascular Ehlers Danlos syndrome.pdf

, 2022
The vascular subtype of Ehlers Danlos Syndrome (vEDS) is a rare connective tissue disorder characterized by spontaneous arterial, bowel or organ rupture.
Ashikh Seethy (7382295), Janvie Manhas (690626), Shivanand Gamanagatti (13935549), Uma Kumar (4808583), Sudip Sen (690627), Lov Raj Lohani (13935546)   +5 more
core   +1 more source

TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains

Advanced Science, EarlyView.
Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang, Xiao Wang, Hongyan Ma, Pengcheng Lyu, Shuangjie Tian, Ruojun Zong, Jiani Chen, Gang Ren, Yongjiang Yang, Zichen Yang, Guosong Qin, Naishi Li, Yanfang Wang, Jianwei Jiao, Jianguo Zhao   +14 more
wiley   +1 more source