Results 81 to 90 of about 21,356 (260)

Tsk2/+ Mice Demonstrate Increased TWEAK/FN14 and TGF-β Pathways During Early Dermal Fibrosis

Rheumato
Background/Objectives: Our prior work demonstrated that a non-synonymous mutation in procollagen type III (Col3a1) at residue 33 (C33S) was responsible for the skin fibrosis seen in the Tsk2/+ mouse. We previously showed increased expression of the TWEAK
Chelsea M. Burgwin, Laura Cort, Kristen B. Long, Elizabeth P. Blankenhorn, Carol M. Artlett   +4 more
doaj   +1 more source

Bioinformatics identification of key genes associated with the prognosis of gastric cancer [PDF]

精准医学杂志
Objective To screen and identify key genes and pathways associated with the prognosis of gastric cancer, and to investigate the mechanisms of the development and progression of gastric cancer.
LIU Zhao, LIU Rui, FAN Haijing, SUN Hui, LYU Jing, ZHANG Zhen
doaj   +1 more source

A CD14‐Targeting In Situ Hydrogel Directs Macrophage Reprogramming to Minimize Scar Formation

Advanced Science, EarlyView.
A CD14‐targeting in situ hydrogel formed from a microbial polysaccharide rapidly remodels the immune microenvironment by reprogramming macrophage polarization, suppressing excessive inflammation, and coordinating tissue regeneration. This multifunctional hydrogel promotes scar‐reduced wound repair through enhanced angiogenesis, collagen remodeling, and
Rui Fang, Simeng Chen, Qiaozhen Liu, Wenwen Ni, Xi Xu, Jianfa Zhang   +5 more
wiley   +1 more source

COL3A1在胃癌中的表达及意义

Zhongguo shiyan zhenduanxue, 2022
目的 检测胃癌及其正常组织中COL3A1的mRNA及蛋白表达水平,初步探究COL3A1与胃癌临床及病理特征的关系。方法 从胃癌手术患者癌组织及其正常组织中收集新鲜标本各10例,石蜡标本各50例,分别使用实时定量PCR法(Quantitative Real-time PCR)和免疫组化法检测COL3A1mRNA及蛋白水平的表达。同时,收集受检患者临床资料,分析COL3A1的表达与胃癌临床病理特征(性别、年龄、分化程度、淋巴转移、TNM分期、肿瘤浸润深度及肿瘤大小)的关系。结果 (1 ...
doaj  

Restoring Endothelial Mitochondrial Homeostasis With a Bioactive Nanoshield Promotes Vascular Regeneration on Cardiovascular Implants

Advanced Science, EarlyView.
A bioactive poly(citrate‐polyglycol‐procyanidin) (PCGP) nanoshield is developed for cardiovascular implants to restore endothelial mitochondrial homeostasis following vascular injury. By preserving mitochondrial integrity, re‐establishing metabolic balance, and activating PI3K/Akt/eNOS‐NO signaling, the PCGP interface promotes functional endothelial ...
Xiyu Liu, Wen Zhang, Lunxin Liu, Lan Gui, Yumei Qin, Xiaohui Yang, Longjian Zhang, Chaohua Wang, Jinpeng Hu, Gaoyang Guo, Qing Jiang, Jin Wang, Li Yang, Bo Zhang, Yunbing Wang   +14 more
wiley   +1 more source

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair

Advanced Science, EarlyView.
Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo, Joe G. Rizk, Emilia Calvano, Rajesh Sahu, Emina Colovic, Imane Chabba, Valentine Gilbart, Erwan Grandgirard, Bastien Morlet, Qingshuang Cai, Daniel Metzger, Delphine Duteil   +11 more
wiley   +1 more source

Transcriptome analysis of skin fibroblasts with dominant negative COL3A1 mutations provides molecular insights into the etiopathology of vascular Ehlers-Danlos syndrome. [PDF]

PLoS ONE, 2018
Vascular Ehlers-Danlos syndrome (vEDS) is a dominantly inherited connective tissue disorder caused by mutations in the COL3A1 gene that encodes type III collagen (COLLIII), which is the major expressed collagen in blood vessels and hollow organs.
Nicola Chiarelli, Giulia Carini, Nicoletta Zoppi, Marco Ritelli, Marina Colombi   +4 more
doaj   +1 more source

Overrepresentation of the COL3A1 AA genotype in Polish skiers with anterior cruciate ligament injury

, 2015
Although various intrinsic and extrinsic risk factors for anterior cruciate ligament (ACL) rupture have been identified, the exact aetiology of the injury is not yet fully understood.
M Stępień-Słodkowska, M Sawczuk, P Ziętek, A Pokrywka, P Zmijewski, P Cięszczyk, A Maciejewska-Karłowska, P Król, K Ficek   +8 more
core   +1 more source

Periostin‐CCL3 Feedforward Signaling Loop Promotes Cardiac Fibrosis and Cardiomyocyte Necroptosis in Arrhythmogenic Cardiomyopathy

Advanced Science, EarlyView.
POSTN‐CCL3 signaling forms a feed‐forward circuit between cardiomyocytes and cardiac myofibroblasts in arrhythmogenic cardiomyopathy. POSTN activates JNK/RIP3‐dependent necroptotic signaling and JNK/ETS2‐induced CCL3 expression in cardiomyocytes. In turn, CCL3‐CCR5 signaling in cardiac myofibroblasts activates NF‐κB/p65 and promotes POSTN expression ...
Tiantian Wu, Ruotong Li, Xiaoyue Zhang, Dandan Chen, Jianmeng Yang, Mengmeng Li, Yuhan Yin, Ya Wang, Yuqiu Tian, Haoling Yan, Dan Cui, Jiangping Song, Gaoliang Ouyang   +12 more
wiley   +1 more source

miR-29a/b target the SPARC/COL3A1 pathways in NPC cells.

, 2015
(A, B) S18 cells were transfected with 50 nmol of mimics-NC (control miRNA), mimics-miR-29a/b, anti-scramble (control anti-miRNA) and anti-miR-29a/b. The levels of miR-29a and miR-29b were assessed by qRT-PCR.
Xuejun Wang (174299), Rui Sun (177521), Ning Deng (701000), Qing Zhang (1802), Bingcheng Zou (704716), Ying Yu (7066), Tao Ling (704718), Jun Xie (53987), Tao Jing (446315), Tianyu Guo (704714), Yange Cao (704715), Feifei Qiu (704713), Songmei Zhang (704717)   +12 more
core   +1 more source