Results 91 to 100 of about 21,356 (260)
Ogerin inhibits TGF-β induced Col3A1 Transcription.
, 2022 Primary human lung fibroblasts derived from non-fibrotic or IPF patients were co-treated with 1ng/mL TGF-β and/or 50–150μM Ogerin for 48 hours. Col3a1 RNA transcript levels were analyzed via qRT-PCR.
Tyler J. Bell (13170733) +3 more
core +1 more source
Mapping Embryonic Mouse Lung Development Using Enhanced Spatial Transcriptomics
Advanced Science, EarlyView.The mammalian lung contains ∼50 cell types arranged along the airway epithelium. Here, deterministic barcoding sequencing (DBiT‐seq) is optimized to nearly double transcript recovery, enabling highly sensitive spatial mapping of the embryonic mouse lung.
Pengfei Zhang +5 more
wiley +1 more source
Frontiers in ImmunologyBackgroundMonocyte/macrophage (Mo/Mp) is a critical cell population involved in immune modulation of rheumatoid synovitis (RA) across different pathotypes.
Xuantao Hu +20 more
doaj +1 more source
Independent groups of Col3a1+/G182R control mice performed over time.
, 2022 Kaplan-Meier Survival curve for comparing the 5 Col3a1+/G182R male control groups. No significant difference is observed using Log-Rank (Mantel-Cox) analysis (p = 0.7881). (TIFF)
Irmine Loisel-Ferreira (12197672) +11 more
core +1 more source
Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer
Advanced Science, EarlyView.Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang +17 more
wiley +1 more source
The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ
Advanced Science, EarlyView.UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi +6 more
wiley +1 more source
Titanium nanotubes activate genes related to bone formation in vitro
Dental Research Journal, 2012 Background: Titanium is used worldwide to make osseointegrable devices, thanks to its favorable characteristics as mechanical proprieties and biocompatibility, demonstrated by in vivo studies with animal models and clinical trials over a forty-year ...
Alfonso Pozio +4 more
doaj +1 more source
Advanced Science, EarlyView.In normal hepatocytes, FBP1 forms compartmentalized complexes with PKM2, ENO1, and LDHA independent of its catalytic activity, inhibiting PKM2 activity and restricting excessive glycolysis. During MASLD progression, FBP1 downregulation markedly reduces the abundance of these complexes and releases the “hijacked” glycolytic enzymes, leading to PKM2 ...
Busong Wang +10 more
wiley +1 more source
Frontiers in ImmunologyBackgroundCoagulation is an important physiological process for the body to cope with vascular injury, involving platelet activation, coagulation factor cascade reaction and fibrin formation.
Liangkun Huang +5 more
doaj +1 more source
The pial BM is well formed at E10.5 but subsequently disrupted in the Col3a1−/− neocortex.
, 2013 (A–H) Double IHC of Tuj1 and Collagen III in E10.5, E11.5, E12.5, and E14.5 brains. Collagen III was absent in all analyzed brains of Col3a1−/− mice.
Rong Luo (187167) +4 more
core +1 more source