Results 111 to 120 of about 21,356 (260)

The Relationship Between COL3A1 Exon 31 Polymorphism and Pelvic Organ Prolapse

Journal of Urology, 2009
We investigated the role of COL3A1 exon 31 polymorphism (a single base substitution from guanine to adenine at +2092), resulting in the replacement of alanine with threonine at the 698th amino acid of COL3A1, in the pathogenesis of pelvic organ prolapse.A total of 72 postmenopausal Korean women who were not on hormonal replacement therapy and who had a
Myung Jae, Jeon, Sue Min, Chung, Jong Rak, Choi, Hyun Joo, Jung, Sei Kwang, Kim, Sang Wook, Bai   +5 more
openaire   +3 more sources

Poly(I:C)‐Activated Nasal Fibroblasts Promote Eosinophil Recruitment in CRSwNP

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by persistent mucosal inflammation and eosinophilic infiltration. Although epithelial and immune cells have been widely studied, the role of nasal fibroblasts in innate immune activation and eosinophil recruitment remains unclear.
Chaewon Shin, An‐Gi Kim, Byeong Min Yu, Woo‐Keun Kwon, Min‐Ho Hwang, Joo‐Hoo Park   +5 more
wiley   +1 more source

Circulating Exosomes Drive Persistent Neuronal Dysfunction in Post‐Herpetic Neuralgia Patients

Annals of Neurology, EarlyView.
Proposed model of exosome‐mediated neuronal dysfunction in post‐herpetic neuralgia (PHN). (1) Circulating, non‐pathogenic exosomes maintain homeostatic processes in healthy skin, where sensory nerve fibers innervate the epidermis and dermis. (2) During acute zoster, reactivating varicella zoster virus (VZV) travels down neurites to the skin causing ...
Christy S. Niemeyer, Seth Frietze, Serena W.R. Lewis, Emily C. Artman, Christina Coughlan, Safa I. Vaseemuddin, Arianna Gentile Polese, Maria A. Nagel, Stephen K. Tyring, Fyona Okundia, Anthony J. Saviola, Gary C. Curhan, Sharon G. Curhan, Diego Restrepo, Andrew N. Bubak   +14 more
wiley   +1 more source

Tranilast inhibits the expression of genes related to epithelial-mesenchymal transition and angiogenesis in neurofibromin-deficient cells

Scientific Reports, 2018
Neurofibromatosis type 1 (NF1) is caused by germline mutations in the NF1 gene and is characterized by café au lait spots and benign tumours known as neurofibromas.
Ritsuko Harigai, Shigeki Sakai, Hiroyuki Nobusue, Chikako Hirose, Oltea Sampetrean, Noriaki Minami, Yukie Hata, Takashi Kasama, Takanori Hirose, Toshiki Takenouchi, Kenjiro Kosaki, Kazuo Kishi, Hideyuki Saya, Yoshimi Arima   +13 more
doaj   +1 more source

G to A polymorphism in exon 31 of the COL3A1 gene [PDF]

Nucleic Acids Research, 1990
K, Zafarullah, C, Kleinert, G, Tromp, H, Kuivaniemi, S, Kontusaari, Y L, Wu, A, Ganguly, D J, Prockop   +7 more
openaire   +2 more sources

Supplementary Figure 4 from RNF185 Control of COL3A1 Expression Limits Prostate Cancer Migration and Metastatic Potential

S4. RT-qPCR validation of RNF185, COL3A1 and COL5A2 expression in RNF185 and COL3A1 KD PC3 cells.
Ze'ev A. Ronai (15055921), Htoo Zarni Oo (16461908), Martin Gleave (16799565), Benjamin Van Espen (17718071), Alfredo Molinolo (16016044), Kevin Yip (17718077), Rabi Murad (16016047), Ladan Fazli (17718074), Colin Collins (16461917)   +8 more
core   +1 more source

Fasting and Refeeding Mediated Phospholipid Remodeling Plays an Important Role in Improving Meat Quality of Aged Laying Hens

Animal Research and One Health, EarlyView.
ABSTRACT This study explored fasting‐induced physiological remodeling effects on meat quality in aged laying hens. Fasting for 15 days (F15) significantly reduced abdominal fat, intermuscular fat width, subcutaneous fat thickness, and liver index versus pre‐fasting (F0) (p < 0.05), which recovered post‐refeeding.
Xiaoran Zhang, Jun Zhang, Yadong Tian, Donghua Li, Yanhua Zhang, Lujie Zhang, Yujie Gong, Xiangtao Kang, Ruirui Jiang   +8 more
wiley   +1 more source

Metabolic-proteomic determinants and immunogenetic transcriptomics of wound healing in plastic and reconstructive surgery: a cohort study

Mìžnarodnij Endokrinologìčnij Žurnal
Background. Perioperative care and postoperative complications, such as impaired wound healing, infection, flap or graft failure, pathological scarring, remain a significant clinical challenge, negatively affecting patient outcomes and satisfaction.
L.P. Sydorchuk, R.M. Gumennyi, A.R. Sydorchuk, V.L. Vasiuk, Sai Praveen Daruvuri, I.V. Batih   +5 more
doaj   +1 more source

The Nuclear Receptor Testicular Receptor 4 Orchestrates Cytoskeletal Organization in a G Protein Subunit Alpha 12/Rho‐Associated Protein Kinase–Dependent Manner to Promote Myofibroblast Differentiation and Tissue Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Members of the superfamily of nuclear receptors have been implicated in inflammatory processes and pathologic tissue remodeling and have emerged as attractive targets for pharmaceutical intervention. However, the role of testicular receptor 4 (TR4; or Nr2c2) in fibroblast activation and rheumatologic diseases has not yet been investigated ...
Yun Zhang, Lichong Shen, Junhui Zheng, Gisela Baur, Dilidaer Yasen, Honglin Zhu, Yi‐Nan Li, Xianyi Meng, Thuong Trinh‐Minh, Tim Filla, Debomita Chakraborty, Andrea‐Hermina Györfi, Christina Bergmann, Adam Reich, Alexander Kreuter, Georg Schett, Jörg H. W. Distler   +16 more
wiley   +1 more source

The role of fibromodulin in myocardial fibrosis in a diabetic cardiomyopathy rat model

FEBS Open Bio
Diabetic cardiomyopathy (DCM) is pathologically characterized by excessive deposition of extracellular matrix proteins, leading to myocardial fibrosis. Fibromodulin (Fmod) plays a crucial role in the pathogenesis of fibrotic diseases.
Xiyan Dai, Fan Yang, Dongping Chen, Lu Yang, Zhihui Dong, Can Chen, Jianmin Xiao   +6 more
doaj   +1 more source