Results 101 to 110 of about 21,356 (260)

Nascent Extracellular Matrix Converts Biomaterial Cues into Cell Fate Decisions

Advanced Science, EarlyView.
This study uncovers a tri‐directional interplay among cells, hydrogels, and their nascent extracellular matrix. Hydrogel norbornene modification alters CD44‐mediated cell–hydrogel interactions, which shape nascent matrix deposition, composition, and spatial organization.
Joshua Y. Liu, Ziqian Yang, Arina E. Velieva, Eleanor M. Plaster, Mingyue Fan, Donia W. Ahmed, Avinava Roy, Pamela Duran, Pamela Panovich, Alexandra S. Piotrowski‐Daspit, Carlos A. Aguilar, Megan L. Killian, Claudia Loebel   +12 more
wiley   +1 more source

DUET‐seq: An Open‐Source Droplet Platform for High‐Fidelity Joint Chromatin and Transcriptome Profiling Reveals Temporal Regulatory Decoupling in Single Cells

Advanced Science, EarlyView.
DUET‐seq is an open‐source droplet platform that jointly profiles chromatin accessibility and gene expression from the same nucleus. Dissolvable dual‐linker hydrogel beads and a one‐step intra‐droplet RT‐PCR co‐index both modalities in under 12 h at roughly $0.04 per cell.
Dong Cheng, Zijun Meng, Lan Wei, Pingjing Yang, Fanfan Zhang, Zhiyi Luo, Ting Lai, Chunli Li, Mengyao Zhao, Mengqin Xu, Jiaqi Wang, Linjun Li, Huarong Chen, Jin Li, Ailong Huang, Youquan Bu, Liuyang Zhao   +16 more
wiley   +1 more source

Structural Control of Stromal‐Immune Coupling by COL24A1 Underlies Pregnancy Maintenance

Advanced Science, EarlyView.
COL24A1 emerges as a collagen‐associated regulator of maternal‐fetal interface homeostasis. Its deficiency promotes a maladaptive TIMP1‐high stromal state, impaired ECM turnover, collagen accumulation, and stromal–immune dysregulation, contributing to pregnancy loss.
Teng Wu, Lingling Xie, Wenyi Liu, Hanjie Mo, Chengshu Xie, Jing Tang, Zhaorui Wang, Peixuan Lan, Jianping Zhang, Jie Gao, Qionglan Tang, Chunwei Cao, Hui Chen   +12 more
wiley   +1 more source

Supplementary Figure 5 from RNF185 Control of COL3A1 Expression Limits Prostate Cancer Migration and Metastatic Potential

S5. RT-qPCR validation of RNF185 and COL3A1 in stable RNF185 and COL3A1 KD MPC3 cells.
Ze'ev A. Ronai (15055921), Htoo Zarni Oo (16461908), Martin Gleave (16799565), Benjamin Van Espen (17718071), Alfredo Molinolo (16016044), Kevin Yip (17718077), Rabi Murad (16016047), Ladan Fazli (17718074), Colin Collins (16461917)   +8 more
core   +1 more source

Aged ZnO Nanoparticles Promote Breast Cancer Lung Metastasis by Remodeling the Pulmonary Microenvironment Through the CXCL10/Wnt/β‐Catenin Axis

Advanced Science, EarlyView.
In summary, pulmonary exposure to ZnO NPs, particularly aged NPs, promotes breast cancer metastasis by remodelling the lung tumour microenvironment. Aged ZnO NPs enrich M2‐macrophages, MDSCs and activated CAFs to form an immunosuppressive metastatic niche. CXCL10 from these cells drives metastasis via Wnt/β‐catenin activation.
Yong Zhu, Siyu Wang, Tong Lin, Jingyi Zhang, Jingya Yang, Dixiang Kang, Wenting Zhao, Na Yu, Meimei Wang   +8 more
wiley   +1 more source

Radial glial endfeet protrude into the ectopias of Col3a1^−/− mice.

, 2013
(A and B) Double IHC of nestin (green) and laminin (red) at E10.5 showed a parallel arrangement of fibers that terminated in well defined endfeet at the pial surface in both Col3a1+/+ (A) and Col3a1−/− mice (B). (C–F) Nestin+ radial glial endfeet (green)
Rong Luo (187167), Natalie Strokes (189296), Sung-Jin Jeong (336209), Xianhua Piao (189302), Shihong Li (336210)   +4 more
core   +1 more source

Влияние генов COL1A1 и COL3A1 на пролапс тазовых органов у женщин [PDF]

, 2020
Проведение анализа влияния полиморфизмов rs1800012 и rs1107946 гена COL1A1, rs1800255 гена COL3A1 на развитие пролапса тазовых ...
Устюжина, А. С., Полоников, А. В., Пахомов, С. П., Матросова, А. В., Солодилова, М. А., Шокирова, У. Г.   +5 more
core  

Mac‐2 Binding Protein Glycosylation Isomer (M2BPGi)–Based Risk Stratification Refined by Tumor Metabolic Activity in Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
M2BPGi reflects background liver fibrosis and hepatic functional impairment. PET SUVmax reflects tumor metabolic aggressiveness. Their combination identifies a dual‐high subgroup with the poorest recurrence‐free and overall survival. ABSTRACT Aim To evaluate the prognostic significance of preoperative Mac‐2 binding protein glycosylation isomer (M2BPGi)
Kojiro Shirabe, Junya Mita, Shinji Itoh, Takeo Toshima, Yoshiyuki Kitamura, Norifumi Iseda, Takuro Isoda, Kousei Ishigami, Tomoharu Yoshizumi   +8 more
wiley   +1 more source

The Novel Association of a Single Nucleotide Variant in the COL3A1 Gene with Diffuse Coronary Aneurysms

Current Issues in Molecular Biology
The COL3A1 gene, encoding the pro-alpha chain of type III collagen, has been implicated in a range of collagen-mediated diseases such as Ehlers–Danlos syndrome and aortic aneurysms.
Charlene Norgan Radler, Kevin Ku, Alison Hodge, Tianci Wang, Peyton Moore, Mohanakrishnan Sathyamoorthy   +5 more
doaj   +1 more source

COL3A1 Gene Polymorphism and Its Impact on Female Pelvic Organ Prolapse

Medical Science Monitor
Pelvic organ prolapse (POP) is a women's health problem in both developed and developing countries. Various studies have found that the occurrence of POP is related to the supporting structures of the pelvic floor, including type III collagen levels. Most studies reported no correlation between collagen 3 alpha 1 (COL3A1) rs1800255 gene polymorphism ...
Kurniawati, Eighty Mardiyan, Rahmawati, Nur Anisah, Widyasari, Anis   +2 more
openaire   +2 more sources