Results 91 to 100 of about 77,446 (306)
Gout and NLRP3 inflammasome biology
Arthritis &Rheumatology, Accepted Article.This review describes the three broad stages of acute inflammation in the context of gout: initiation, leucocyte mobilisation, and self‐resolution. A typical case of a gout flare is presented. The role of the NLRP3 inflammasome in acute monosodium urate crystal‐induced inflammation is reviewed in detail.
Raewyn Poulsen, Nicola Dalbeth
wiley +1 more source
Plant, Cell &Environment, Volume 46, Issue 2, Page 422-439, February 2023., 2023 Abstract PSBO is essential for the assembly of the oxygen‐evolving complex in plants and green algae. Despite its importance, we lack essential information on its lifetime and how it depends on the environmental conditions. We have generated nitrate‐inducible PSBO amiRNA lines in the green alga Chlamydomonas reinhardtii.
André Vidal‐Meireles +6 more
wiley +1 more source
Factors Affecting Colchicine Adherence in Pediatric Familial Mediterranean Fever
Journal of Pediatric Research, 2023 Aim:Familial Mediterranean Fever (FMF) is the most frequent monogenetic autoinflammatory disorder. It is characterized by fever and serositis. The first line treatment of FMF is colchicine.
Esra Nagehan Akyol Önder +3 more
doaj +1 more source
Mechanical deformation of monocytic THP-1 cells : occurrence of two seqential phases with differential sensitivity to metabolic inhibitors [PDF]
Experimental Biology Online - EBO 2 (1997) 5, 2007 Blood leukocytes can exhibit extensive morphological changes during their passage through small capillary vessels. The human monocytic THP-1 cell line was used to explore the metabolic dependence of these shape changes. Cells were aspirated into micropipettes for determination of the rate of protrusion formation.
arxiv
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, 2020 Background Colchicine has been used in conditions such as periodic febrile illness, acute pericarditis, and gouty arthritis, all having a common hyperinflammatory response as seen in moderate to severe forms of coronavirus disease 2019 (COVID-19).
Tegveer Sandhu +3 more
semanticscholar +1 more source
Nonconventional Techniques in Plant Alkaloid Extraction: A Decade of Progress (2014–2023)
Chemistry &Biodiversity, EarlyView.This figure seeks to represent the evolution of the different unconventional approaches that were adopted for the extraction of plant‐derived alkaloids during the decade from 2014 to 2023. ABSTRACT Plant metabolism encompasses primary and secondary pathways, with secondary metabolism yielding diverse natural products crucial for plant adaptation and ...
Victor Menezes Sipoloni +5 more
wiley +1 more source
Colchicine to Weather the Cytokine Storm in Hospitalized Patients with COVID-19
Journal of Clinical Medicine, 2020 The repurposing of colchicine for the treatment of COVID-19 was suggested based in its immunomodulatory, anti-inflammatory, and anti-viral properties. We performed a single-center propensity score matched cohort study, including all consecutive COVID-19 ...
L. Brunetti +6 more
semanticscholar +1 more source
Immune Checkpoint Inhibitors and Cardiovascular Adverse Events
ESC Heart Failure, EarlyView.Abstract In the last years, we assisted to a tremendous increase in therapeutic options for the management of cancers, with immunotherapy at the forefront of this innovation. Immune checkpoint inhibitors (ICIs) have been developed to enhance the activity of the immune system against cancer cells (1) and the number of approvals for ICIs has rapidly ...
Maria Luisa De Perna +4 more
wiley +1 more source
European Heart Journal - Quality of Care and Clinical Outcomes, 2020 Aims In the randomized, placebo-controlled Colchicine Cardiovascular Outcomes Trial (COLCOT) of 4745 patients enrolled within 30 days after myocardial infarction (MI), low-dose colchicine (0.5 mg once daily) reduced the incidence of the primary composite
M. Samuel +25 more
semanticscholar +1 more source
European Journal of Heart Failure, EarlyView.New anticancer therapies with potential cardiovascular side effects are continuously being introduced into clinical practice, with new and often unexpected toxicities becoming apparent only after clinical introduction. These unknown toxicities should be identified and understood beforehand to better prepare patients and physicians, enabling the ...
Alessandra Ghigo +22 more
wiley +1 more source