Results 161 to 170 of about 45,519 (269)

High‐intensity statin therapy is associated with reduced coronary inflammation on CT in patients with type 2 diabetes mellitus

open access: yesDiabetes, Obesity and Metabolism, Volume 27, Issue 11, Page 6395-6402, November 2025.
Abstract Aims Pericoronary adipose tissue (PCAT) attenuation, assessed by coronary computed tomography angiography (CCTA), is a biomarker of coronary inflammation. Mean PCAT attenuation ≥ −70.5 Hounsfield Units (HU) corresponds to elevated inflammation and a higher future risk of myocardial infarction.
Bryan Wu, Koen Nieman, Ryan Sandoval
wiley   +1 more source

Molecular breeding approaches for the improvement of oil content and fatty acid composition in exotic‐derived maize germplasm

open access: yesNew Phytologist, Volume 248, Issue 4, Page 1920-1939, November 2025.
Summary Molecular breeding strategies such as genome‐wide association studies (GWAS) and genomic prediction have revolutionized crop improvement by enhancing selection accuracy and genetic gains. Through a comprehensive evaluation of a large set of maize lines from Germplasm Enhancement of Maize (BGEM) and their testcross hybrids, we aimed to ...
Alison Uberti   +4 more
wiley   +1 more source

Cytotoxicity of Atropisomeric [1,1′‐Binaphthalene]‐2,2′‐Diamines (BINAM) and Analogs in Human Cancer Cells: Enantioselectivity, Structure–Activity Relationships, and Mechanism

open access: yesChemMedChem, Volume 20, Issue 19, October 6, 2025.
It is reported for the first time that atropisomeric (R)‐[1,1′‐binaphthalene]‐2,2′‐diamine (R‐BINAM, 1(R)), but not (S)‐[1,1′‐binaphthalene]‐2,2′‐diamine (S‐BINAM, 1(S)), is a moderately potent spindle poison, causing antiproliferation, depolymerization of microtubules, multipolar spindles, pericentriolar material (PCM) fragmentation, mitotic ...
Malte Eichelbaum, Patrick J. Bednarski
wiley   +1 more source

Repeat Expansions in PLIN4 Cause Autosomal Dominant Vacuolar Myopathy With Sarcolemmal Features

open access: yesAnnals of Clinical and Translational Neurology, Volume 12, Issue 10, Page 2136-2151, October 2025.
ABSTRACT Objective We aim to describe and characterize two unrelated Spanish families suffering from an autosomal dominant autophagic vacuolar myopathy caused by repeat expansions in PLIN4. Methods We evaluated the clinical phenotype and muscle imaging, and performed a genetic workup that included exome sequencing, muscle RNAseq, and long‐read genome ...
Laura Llansó   +17 more
wiley   +1 more source

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