Results 141 to 150 of about 78,062 (255)

Carrier screening in the reproductive setting—Are there medical implications for the heterozygote?—A guide for clinicians

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld, Nicole Kasatkin, Bi Liu Yu, Milen Velinov, Justin S. Brandt, Elena Ashkinadze   +5 more
wiley   +1 more source

Guideline of guidelines: Peyronie's disease

BJU International, Volume 137, Issue 5, Page 770-782, May 2026.
Objective To compare major Peyronie's disease (PD) guidelines, highlight key similarities and differences among panel recommendations, and identify areas requiring further research. Methods An extensive review was conducted to analyse and compare diagnostic and treatment recommendations from publicly available guidelines published by the American ...
Francesco Chierigo, Giuseppe Fallara, Marco Tozzi, Andrea Salonia, Matteo Ferro, Hussain M Alnajjar, Asif Muneer, Karl H. Pang   +7 more
wiley   +1 more source

Management and Prognosis of Patients With Acute Pericarditis in the Emergency Department: A Retrospective, Single‐Centre Study

European Journal of Clinical Investigation, Volume 56, Issue 5, May 2026.
In this retrospective, single‐centre study conducted in patients with acute pericarditis referred to the Emergency Department, a significant proportion of patients experienced long‐term complications, especially recurrences. Drug doses were compliant with guidelines in a limited number of patients at admission and increased at discharge. Diabetes, COPD,
Lisa Caldera, Chiara Lovati, Alessandra Vecchié, Walter Ageno, Marco Paolo Donadini, Francesco Dentali, Flavio Tangianu, Aldo Bonaventura   +7 more
wiley   +1 more source

Inhibitory Activity of Conferone on FAK Activity and Glutamine Metabolism in Human Colorectal Cancer

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Colorectal cancer (CRC) is a major global cause of death, with metastases and chemotherapy resistance contributing to poor outcomes. To identify natural compounds with anticancer potential against CRC and elucidate their action mechanisms, the cytotoxicity of 37 natural compounds was evaluated against the HCT116, leading to the identification ...
Hien Thi My Ong, Eda Ates, Jaeyong Jung, Jeong Soo Sung, Jae‐Chul Pyun, Min‐Jung Kang   +5 more
wiley   +1 more source

AlkaPlorer: A database‐driven explorer for natural alkaloids and derivatives

Journal of Integrative Plant Biology, Volume 68, Issue 5, Page 1384-1398, May 2026.
The alkaloid database AlkaPlorer integrates over 130,000 compounds across 12,250 species. By linking chemical structures with biological and evolutionary data, it reveals how these molecules evolve and function. This platform serves as a vital resource for AI‐driven discovery in plant metabolism and modern drug development. ABSTRACT Alkaloids, renowned
Jiahao Li, Tao Zeng, Hongquan Xu, Xu Kang, Minghui Liang, Ruibo Wu   +5 more
wiley   +1 more source

Samplify: a versatile tool for image‐based segmentation and annotation of seed abortion phenotypes

New Phytologist, Volume 250, Issue 3, Page 1964-1978, May 2026.
Summary Automated seed phenotyping has wide applications in research and agriculture and relies on easy‐to‐use platforms and pipelines. Seed phenotyping in the model species Arabidopsis thaliana poses a significant challenge due to the large number of tiny seeds produced by individual plants, which are difficult to manually separate and count.
Heinrich Bente, Ronja Lea Jennifer Müller, Andreas Donath, Dirk Walther, Claudia Köhler   +4 more
wiley   +1 more source

Haploid Mutation Mapping Identifies a Homoeologous Non‐Reciprocal Translocation Linked to Reduced Fibre and Enhanced Protein in Brassica napus

Plant Biotechnology Journal, Volume 24, Issue 5, Page 3219-3243, May 2026.
ABSTRACT A key challenge for the genetic improvement of canola (Brassica napus), one of the world's most important oilseeds, is the limited natural variation for commercially important traits. The creation of new variation is hindered by the lack of functional knowledge about genes controlling these traits.
Morgan W. Kirzinger, Sarika Saini, Andrea T. Todd, Ushan Alahakoon, Kevin C. Koh, Justin B. Nichol, HaiYing Yuan, Kevin Fengler, Victor Llaca, Dustin Cram, Sampath Perumal, Wali Soomro, Magda Konopka, Tancey Melchkart, Venkat Bandi, Yasmina Bekkaoui, Yifang Tan, Chad Matsalla, Andrew G. Sharpe, Carl Gutwin, Fred Thoonen, Igor Falak, Chad Koscielny, Stuart Gardner, Isobel A. P. Parkin, Marcus A. Samuel, Alison M. R. Ferrie, Dave Charne, Daoquan Xiang, Jetty S. S. AmmiRaju, Sateesh Kagale   +30 more
wiley   +1 more source

Flavonoid Oxime Carbamate Derivatives: Reversal of Multidrug Resistance in Cancer Cells

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
A set of 23 new flavonoid oxime carbamates was synthesized and evaluated as multidrug resistance (MDR) reversers in ABCB1‐transfected mouse lymphoma cells. All derivatives strongly inhibited P‐glycoprotein (P‐gp) efflux activity in a transport assay, while most selected compounds behaved as ATPase inhibitors. In drug combination assays, they interacted
Filipa Barbosa, Gabriella Spengler, Noémi Bózsity, Nikoletta Szemerédi, István Zupkó, Maria‐José U. Ferreira   +5 more
wiley   +1 more source

Colchicine and dialysis patients (CAD): protocol for a feasibility study. [PDF]

BMJ Open
Wong YTD, Hughes LD, Norton S, Robson MG.   +3 more
europepmc   +1 more source

Severe Pharyngo-Laryngeal Mucositis During Radiotherapy in a Patient Receiving Colchicine: A Case Report. [PDF]

Clin Case Rep
Vigna Taglianti R, Gianello L, Spinelli L, Martini S, Solla SD, Olivero F, Critelli P, Merlotti A.   +7 more
europepmc   +1 more source