Results 171 to 180 of about 77,446 (306)

Histiocytoid Sweet Syndrome With Paradoxical Neutropenia in a Pediatric Patient

open access: yesPediatric Dermatology, EarlyView.
ABSTRACT Histiocytoid Sweet syndrome (HSS) is a rare inflammatory skin condition characterized by the infiltration of mononuclear cells in the dermis and leukocytosis with neutrophilia. This uncommon variant of classic Sweet syndrome is rarely reported in the literature, especially in pediatric patients.
Shelby Boock   +3 more
wiley   +1 more source

Daphnetin alleviates inflammation and promotes autophagy via the AMPK/mTOR pathway in gouty arthritis

open access: yesJournal of Cell Communication and Signaling, Volume 19, Issue 2, June 2025.
Daphnetin, a coumarin derivative, regulates the AMPK/mTOR signaling pathway to inhibit inflammation and promote autophagy in monosodium urate‐induced mice and THP‐1 cells, thereby suppressing MSU‐induced gouty arthritis. Abstract Gouty arthritis (GA) is an inflammatory disease resulting from monosodium urate (MSU) crystal deposition in joints and ...
Zhiyong Liu   +3 more
wiley   +1 more source

β‐Glucuronidase‐Responsive Albumin‐Binding Prodrug of Colchicine‐Site Binders for Selective Cancer Therapy

open access: yesChemMedChem, Volume 20, Issue 9, May 5, 2025.
This study presents a β‐glucuronidase‐responsive albumin‐binding prodrug enabling the selective release within the tumor microenvironment of an Isocombretastatin A‐4 analog. In triple‐negative breast cancer (TNBC) mouse models, this prodrug demonstrated significant tumor growth inhibition, highlighting potential for enhanced therapeutic selectivity and
Alexandra Bordes   +6 more
wiley   +1 more source

Wnt Inhibition Safeguards Porcine Embryonic Stem Cells From the Acquisition of Extraembryonic Endoderm Cell Fates

open access: yesAdvanced Science, Volume 12, Issue 17, May 8, 2025.
The study reports that Wnt inhibitors safeguard porcine embryonic stem cells (ESCs) from acquiring the extraembryonic endoderm (XEN) lineage, and further develop an efficient strategy to derive XEN cells from ESCs. The XEN cells from ESCs exhibit similar transcriptome and chromatin accessibility features to XEN cells from embryos and contribute to ...
Hanning Wang   +4 more
wiley   +1 more source

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