Results 51 to 60 of about 45,519 (269)

Colchicine-Related Polyneuropathy and Multiple Organ Failure

Türk Nöroloji Dergisi, 2013
Colchicine arrests microtubule assembly and inhibits many cellular functions. This drug is used to treat gout and and Familial Mediterranean Fever. Its gastrointestinal side effects are frequent but more severe adverse effects such as neuropathy and ...
Ersel Dağ, Yakup Türkel, Burcu Gökçe
doaj   +1 more source

Effect of Treatment with Colchicine after Acute Coronary Syndrome on Major Cardiovascular Events: A Systematic Review and Meta-Analysis of Clinical Trials

Cardiovascular Therapeutics, 2022
Aim. Colchicine as an anti-inflammatory drug might be effective in the treatment of atherosclerosis, an inflammatory-based condition. The aim of this systematic review and meta-analysis was to evaluate the impact of colchicine on acute coronary syndrome (
Erfan Razavi, Akam Ramezani, Asma Kazemi, Armin Attar   +3 more
doaj   +1 more source

Colchicine in patients with acute ischaemic stroke or transient ischaemic attack (CHANCE-3): multicentre, double blind, randomised, placebo controlled trial

British medical journal
Objectives To assess the efficacy and safety of colchicine versus placebo on reducing the risk of subsequent stroke after high risk non-cardioembolic ischaemic stroke or transient ischaemic attack within the first three months of symptom onset (CHANCE-3).
Jiejie Li, Xia Meng, Fu-Dong Shi, Jing Jing, Hongqiu Gu, A. Jin, Yong Jiang, Hao Li, S. C. Johnston, G. J. Hankey, J. D. Easton, Liguo Chang, P. Shi, Lihua Wang, Xianbo Zhuang, Haitao Li, Y. Zang, Jianling Zhang, Zengqiang Sun, Dongqi Liu, Ying Li, Hongqin Yang, Jinguo Zhao, Weiran Yu, Anxin Wang, Yuesong Pan, Jinxi Lin, Xuewei Xie, Wei-Na Jin, Shuya Li, Siying Niu, Yilong Wang, Xing-hui Zhao, Zixiao Li, Liping Liu, Huaguang Zheng, Yongjun Wang   +36 more
semanticscholar   +1 more source

Colchicine-induced myoneuropathy in a cyclosporine-treated renal transplant recipient

Kidney Research and Clinical Practice, 2013
Colchicine is a relatively safe medication that is widely used for both prevention and treatment of gout attack. However, serious adverse events, including myoneuropathy and multiorgan failure, have been reported.
Kyungmin Huh, Ji Young Joung, Hyemin Jeong, Dongmo Je, Yoon Young Cho, Hye Ryoun Jang, Wooseong Huh   +6 more
doaj   +1 more source

Exploring the Origin of Differential Binding Affinities of Human Tubulin Isotypes αβII, αβIII and αβIV for DAMA-Colchicine Using Homology Modelling, Molecular Docking and Molecular Dynamics Simulations. [PDF]

PLoS ONE, 2016
Tubulin isotypes are found to play an important role in regulating microtubule dynamics. The isotype composition is also thought to contribute in the development of drug resistance as tubulin isotypes show differential binding affinities for various anti-
Bajarang Vasant Kumbhar, Anubhaw Borogaon, Dulal Panda, Ambarish Kunwar   +3 more
doaj   +1 more source

Colchicine in overdose [PDF]

British Journal of General Practice, 2016
Would colleagues please be aware of the devastating consequences of a significant colchicine …
openaire   +3 more sources

Effects of colchicine use on ischemic and hemorrhagic stroke risk in diabetic patients with and without gout

Scientific Reports, 2022
This study aimed to determine the effect of colchicine use on the risk of stroke among patients with diabetes mellitus (DM). We retrospectively enrolled patients with DM between 2000 and 2013 from the Longitudinal Health Insurance Database and divided ...
Jun-Jun Yeh, I-Ling Kuo, Hei-Tung Yip, Min-Yuan Hsueh, Chung-Y. Hsu, Chia-Hung Kao   +5 more
doaj   +1 more source

Reduced mortality in COVID-19 patients treated with colchicine: Results from a retrospective, observational study

PLoS ONE, 2021
Objectives Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed. We hypothesized that colchicine, by counteracting proinflammatory pathways implicated in the uncontrolled inflammatory response of COVID-19 patients, reduces ...
L. Manenti, U. Maggiore, E. Fiaccadori, T. Meschi, A. Antoni, A. Nouvenne, A. Ticinesi, Nicoletta Cerundolo, Beatrice Prati, M. Delsante, Ilaria Gandoflini, Lorenzo Donghi, M. Gentile, M. T. Farina, V. Oliva, C. Zambrano, G. Regolisti, A. Palmisano, C. Caminiti, E. Cocchi, Carlo Ferrari, L. Riella, P. Cravedi, L. Peruzzi   +23 more
semanticscholar   +1 more source

Rhabdomyolysis associated with concomitant use of colchicine and statins in the real world: identifying the likelihood of drug–drug interactions through the FDA adverse event reporting system

Frontiers in Pharmacology
BackgroundCurrently, there remains substantial controversy in research regarding whether the concomitant use of colchicine and statins increases the occurrence of rhabdomyolysis, warranting further substantiation.ObjectiveThis study aimed to identify the
Sha Zhang, Ming-Ming Yan, Hui Zhao, Xiao-Yan Qiu, Deqiu Zhu   +4 more
doaj   +1 more source

Cost‐effectiveness of low dose colchicine prophylaxis when starting allopurinol using the “start‐low go‐slow” approach for gout: evidence from a non‐inferiority randomised double‐blind placebo‐controlled trial.

Arthritis Care &Research, Accepted Article.
Objective The aim of this study was to investigate the cost‐effectiveness of low‐dose colchicine prophylaxis for preventing gout flares when starting allopurinol using the “start‐low go‐slow” approach. Methods Participants with gout, fulfilling the American College of Rheumatology recommendations for starting urate‐lowering therapy and with serum urate
Yana Pryymachenko, Ross Wilson, Nicola Dalbeth, J. Haxby Abbott, Lisa Stamp   +4 more
wiley   +1 more source