Results 71 to 80 of about 45,519 (269)
Live Quantitative Characterization for Stem Cell Biomechanics
Advanced Materials Interfaces, EarlyView.These findings demonstrate an accessible technique for real‐time, high‐resolution mechanical mapping of live stem cells, without the use of specialised probes or advanced modelling techniques. This approach provides direct insight into localised cytoskeletal dynamics under chemical treatment and holds potential for broader application in understanding ...
Kaiwen Zhang +5 more
wiley +1 more source
Frontiers in Plant Science, 2021 Bamboos seldom bloom and almost no seeds could be harvested, and, hence, few works are focused on germination physiology. Systematic research on the physiological effects of colchicine on germination and seedling growth of bamboo seeds is lacking.
Zhuo Lv +9 more
doaj +1 more source
Advanced Science, EarlyView.This study employed tRNASUAG, an anticodon‐engineered tRNA (ACE‐tRNA), to introduce a phosphorylatable serine into the C‐terminal domain of HBc by reading through its stop codon, thereby potentially promoting the ubiquitin‐proteasome degradation of HBc, and subsequently inhibiting HBV replication. Through a tRNASUAG‐gHBV1‐tRNASUAG‐gHBV2‐tRNASUAG tandem
Xingwen Yang +7 more
wiley +1 more source
JACC: Case Reports, 2020 Colchicine toxicity results in fatal multiorgan failure. We present a case of colchicine toxicity resulting in transient biventricular failure and cardiogenic shock that were successfully treated with packed red blood cell exchange. (Level of Difficulty: Beginner.).
Steven E. Reis +7 more
openaire +3 more sources
Colchicine in systemic amyloidosis. [PDF]
Annals of the Rheumatic Diseases, 1984 PubMed ID ...
AKOGLU, E, AKOGLU, T, ERKEN, E
openaire +4 more sources
APOL2 Stabilizes Ku80 to Confer NHEJ‐Mediated Radioresistance in Gastric Cancer
Advanced Science, EarlyView.Radiotherapy resistance in gastric cancer (GC) is often mediated by enhanced DNA repair. APOL2 is found to promote NHEJ by stabilizing Ku80, conferring radioresistance. High APOL2 correlates with poor prognosis. Formononetin disrupts APOL2‐Ku80, restoring radiosensitivity, suggesting a novel therapeutic strategy.
Dan Zu +23 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.Simplified schematic for generation of the subcutaneous air pouch model in the rodent. On day 0 and 4, air is injected into the subcutaneous space on the dorsal surface of the rodent to generate a cavity analogous to a synovial joint. On day 6, monosodium urate (MSU) or calcium pyrophosphate (CPP) crystals are injected into the pouch to stimulate ...
Wenu Hewage +4 more
wiley +1 more source
Peptide/Antibody–Drug Conjugates for Therapeutic Applications in Inflammatory Disease
Advanced NanoBiomed Research, EarlyView.Peptide/antibody–drug conjugates (PADCs) combine ligand specificity and cleavable linkers to deliver drugs precisely to disease sites with minimal toxicity. While current approvals focus on oncology, this review examines their untapped potential in inflammatory diseases, detailing mechanisms of targeted delivery and highlighting advances that position ...
Yeongji Jang +5 more
wiley +1 more source
Frontiers in Cardiovascular Medicine, 2022 BackgroundSeveral trials have considered the safety and clinical benefits of colchicine as a treatment option for secondary prevention in patients with coronary atherosclerotic heart disease (CAD), but its safety and clinical benefits remain ...
Zijun Ma, Jun Chen, Kaiqin Jin, Xin Chen
doaj +1 more source
Colchicine in ischemic heart disease: the good, the bad and the ugly
Clinical Research in Cardiology, 2021 Inflammation is the main pathophysiological process involved in atherosclerotic plaque formation, progression, instability, and healing during the evolution of coronary artery disease (CAD).
D. D’Amario +15 more
semanticscholar +1 more source