Results 71 to 80 of about 50,322 (265)

Comprehensive Transcriptomic and m6A Epitranscriptomic Analysis Reveals Colchicine-Induced Kidney Toxicity via DNA Damage and Autophagy in HK2 Cells

Toxins
Colchicine is commonly prescribed for inflammation and gout, but its nephrotoxicity and underlying mechanisms remain incompletely understood. The objective of this research was to clarify the association between m6A methylation modifications and ...
Kun Tian, Jiaxin Wen, Dongcheng Zhang, Jiaxuan Lin, Lixiang Weng, Lele Yang, Wei Zhao, Chutao Li, An Zhu   +8 more
doaj   +1 more source

Progress in the management of acute colchicine poisoning in adults [PDF]

, 2022
Jiacheng Wu, Zhenning Liu
openalex   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Epigenetic inflammatory memory and periodontal disease: Mechanisms and clinical significance for comorbidities

Journal of Periodontology, EarlyView.
Abstract Historically, immunological memory was considered an exclusive feature of adaptive immunity. However, innate immune cells have recently been shown to record and maintain epigenetically imprinted memory of earlier infectious or inflammatory challenges.
George Hajishengallis
wiley   +1 more source

The role of physical exercise in diseases treated with colchicine - an ancient drug with novel clinical applications

Quality in Sport
Colchicine, a lipid-soluble alkaloid derived from Colchicum autumnale, has a long history of use dating back to ancient Egypt. Traditionally used to alleviate pain and swelling, colchicine is now administered for various diseases, including gout and ...
Julia Rejdych, Katarzyna Podyma, Sara Rosołowska-Żak, Maria Sambura, Wiktoria Sas, Gracja Ryznar, Piotr Pierzchała, Michalina Minkowska, Krystyna Chimiak, Gabriela Bylica   +9 more
doaj   +1 more source

Inhibition of free fatty acid mobilization by colchicine

Journal of Lipid Research, 1974
Segments of epididymal adipose tissue from normal male rats were incubated with micromolar concentrations of colchicine for different periods of time up to 4 hr, and the mobilization of free fatty acids (FFA) was measured during a subsequent reincubation.
Richard J. Schimmel
doaj   +1 more source

Targeted delivery of a colchicine analogue provides synergy with ATR inhibition in cancer cells

, 2022
Francis M. Barnieh, Goreti Ribeiro Morais, Herbie Garland, Paul M. Loadman, Robert A. Falconer   +4 more
openalex   +1 more source

Clinical Features and Therapeutic Outcomes in Pyoderma Gangrenosum: A Prospective Cohort Study

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis highly associated with systemic comorbidities. Accurate diagnosis and treatment remain challenging due to its rarity and clinical mimickers. Objectives To evaluate demographic, clinical features and treatment outcomes in patients referred with suspected PG at a tertiary ...
David Croitoru, Nesrine Brahimi, Haleh Zabihi, Cathryn Sibbald, Kyle Seigel, Delaram Shojaei, Eric McMullen, Afsaneh Alavi, Lily Archaempong, Aaron M. Drucker, Adam Weizman, Kenneth Croitoru, Robert Inman, Vincent Piguet   +13 more
wiley   +1 more source

Colchicine Overdose in a Suicidal Attempt [PDF]

International Journal of Medical Toxicology and Forensic Medicine, 2019
Colchicine overdose is uncommon; however, it can cause serious adverse effects and even death. Colchicine inhibits microtubule polymerization, causing mitotic spindle disruption.
Fatemeh Eghbali, Reza Bidaki, Sina Negintaji, Maryam Dehghani, Adeleh Sahebnasagh, Ali Asghar Bagheri Atabak, Fatemeh Saghafi   +6 more
doaj  

Adverse events during oral colchicine use: a systematic review and meta-analysis of randomised controlled trials

Arthritis Research & Therapy, 2020
Background Colchicine is a widely used drug to treat inflammatory diseases. Due to its long historical use in medicine, controlled clinical trials have been small and there remains some caution with the use of this drug in patients with co-morbidities ...
Sarah Stewart, Kevin Chih Kai Yang, Kate Atkins, Nicola Dalbeth, Philip C. Robinson   +4 more
doaj   +1 more source