Results 71 to 80 of about 77,446 (306)

Endocan: A Novel Marker for Colchicine Resistance in Familial Mediterranean Fever Patients?

Frontiers in Pediatrics, 2021
Introduction: Familial Mediterranean fever (FMF) patients had 5–10% colchicine resistance. Although FMF attacks are characterized by acute phase elevation, there are no biomarkers that can show colchicine resistance yet.
Ahmet Omma, Berkan Armaǧan, Serdar Can Güven, Sevinç Can Sandıkçı, Seda Çolak, Çiǧdem Yücel, Orhan Küçükşahin, Abdulsamet Erden   +7 more
doaj   +1 more source

A Novel Protein‐Polysaccharide Oral Nanoemulsion Targeting Activated Hepatic Stellate Cells to Enhance the Therapeutic Effect of Pirfenidone on Fibrosis After Transarterial Chemoembolization for Liver Cancer

Advanced Functional Materials, EarlyView.
Transarterial Chemoembolization (TACE) may aggravate liver fibrosis. In this study, a novel oral targeting nanoemulsion is fabricated to enhance the therapeutic effect of antifibrotic drug‐pirfenidone (PFD) on fibrosis after TACE. Studies have shown that PFD nanoemulsion can enhance the oral liver targeting effect of PFD, and effectively improve the ...
Zhimei Cheng, Shan Xu, Yi Lei, Huizhou He, Runbin Sun, Xingle Jin, Cheneryu Huang, Yuhao Zheng, Jianqing Peng, Lei Tang, Peng Luo, Yi Chen, Shuai Zhang   +12 more
wiley   +1 more source

Treatment of periodontitis and C‐reactive protein: A systematic review and meta‐analysis of randomized clinical trials

Journal of Clinical Periodontology, Volume 50, Issue 1, Page 45-60, January 2023., 2023
Abstract Background Systemic inflammation is implicated in the onset and progression of several chronic diseases. Periodontitis is a potential trigger of systemic inflammation. Purpose To comprehensively appraise all the evidence on the effects of the treatment of periodontitis on systemic inflammation assessed by serum C‐reactive protein (CRP) levels.
Shailly Luthra, Marco Orlandi, Syed Basit Hussain, Yago Leira, João Botelho, Vanessa Machado, José João Mendes, Debora Marletta, Simon Harden, Francesco D'Aiuto   +9 more
wiley   +1 more source

Colchicine effects on the ploidy level and morphological characters of Katokkon pepper (Capsicum annuum L.) from North Toraja, Indonesia

Journal of Genetic Engineering and Biotechnology, 2021
Background Productivity and quality of crops can be increased through polyploidy plants induced by colchicine. The use of colchicine has never been applied to Katokkon pepper, a local red pepper variety from North Toraja Indonesia.
Reisky Megawati Tammu, Tri Rini Nuringtyas, Budi Setiadi Daryono   +2 more
doaj   +1 more source

Effectiveness of colchicine among patients with COVID-19 infection: A randomized, open-labeled, clinical trial

Indian Journal of Rheumatology, 2022
Background and Objective: In November 2019, there were abundant cases of COVID-19 which first case was reported in Wuhan, China. Colchicine has an important role in inhibiting activation of NLRP3 inflammasome that predispose to decrease cytokine ...
Aryan Mohamadfatih Jalal, Sheelan Faroz Aref, Dashty Abbas Albustany   +2 more
doaj   +1 more source

Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization

Advanced Science, EarlyView.
This study shows that macrophage interferon regulatory factor 4 (IRF4) improved arterial injury‐induced neointimal hyperplasia by promoting of M2 polarization via up‐regulating krüppel‐like factor 4 (KLF4) in rodent and nonhuman primate models. Notably, artesunate is identified as a potent inducer of IRF4 in macrophages, and proposed as a promising ...
Jinlin Miao, Yule Yong, Zhaohui Zheng, Kui Zhang, Wei Li, Jiayi Liu, Siyi Zhou, Juan‐juan Qin, Haoyang Sun, Yatao Wang, Xianghui Fu, Xing Luo, Siyu Chen, Zhi‐Gang She, Jingjing Cai, Ping Zhu   +15 more
wiley   +1 more source

Oxygen Saturation in Hospitalized COVID-19 Patients and Its Relation to Colchicine Treatment: A Retrospective Cohort Study with an Updated Systematic Review

Medicina, 2023
Background: Colchicine has been proposed as a cytokine storm-blocking agent for COVID-19 due to its efficacy as an anti-inflammatory drug. The findings of the studies were contentious on the role of colchicine in preventing deterioration in COVID-19 ...
Sandy Sharaf, Rasha Ashmawy, Eman Saleh, Mayada Salama, Yousra A. El-Maradny, Ali Zari, Shahinda Aly, Ahmed Tolba, Doaa Mahrous, Hanan Elsayed, Dalia Latif, Elrashdy M. Redwan, Ehab Kamal   +12 more
doaj   +1 more source

Paclitaxel/Luteolin Coloaded Dual‐Functional Liposomes for Esophageal Cancer Therapy

Advanced Science, EarlyView.
The authors develop a pH‐sensitive aptamer‐modified liposome (EA2‐PSL‐PTX/LUT) to illustrate a strategy for the precise delivery of combinational chemotherapeutic drugs for esophageal squamous cell carcinoma (ESCC) targeted therapy. EA2‐PSL‐PTX/LUT provides efficient co‐loading, tumor targeting, and controlled release of luteolin and paclitaxel ...
Congyong Sun, Fei Xie, Huiyun Zhang, Lulu Feng, Yuting Wang, Chaofan Huang, Zhizhen Cui, Chao Luo, Li Zhang, Qilong Wang   +9 more
wiley   +1 more source

Colchicine Inhibits Neutrophil Extracellular Trap Formation in Patients With Acute Coronary Syndrome After Percutaneous Coronary Intervention

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2020
Background Release of neutrophil extracellular traps (NETs) after percutaneous coronary intervention (PCI) in acute coronary syndrome (ACS) is associated with periprocedural myocardial infarction, as a result of microvascular obstruction via pro ...
K. Vaidya, B. Tucker, R. Kurup, C. Khandkar, E. Pandžić, J. Barraclough, Joshua Machet, A. Misra, M. Kavurma, G. Martínez, K. Rye, B. Cochran, Sanjay Patel   +12 more
semanticscholar   +1 more source

Macrophage WEE1 Directly Binds to and Phosphorylates NF‐κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis

Advanced Science, EarlyView.
The present study shows that macrophage WEE1 drives NF‐κB activation and inflammatory atherosclerosis by directly phosphorylating p65 at S536. This finding illustrates a macrophage‐specific WEE1‐p65 axis in regulating inflammatory atherosclerosis and points out new directions to broaden the clinical applications for WEE1 inhibitors in atherosclerosis ...
Zhuqi Huang, Sirui Shen, Weixin Li, Mengyang Wang, Yudie Yang, Wu Luo, Xue Han, Zheng Xu, Julian Min, Xiaohong Long, Weijian Huang, Gaojun Wu, Yi Wang, Guang Liang   +13 more
wiley   +1 more source